PMID- 31608722
OWN - NLM
STAT- MEDLINE
DCOM- 20200526
LR  - 20200526
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 11
IP  - 16
DP  - 2019 Nov
TI  - Dendritic cell-based vaccine targeting aspartate-beta-hydroxylas represents a 
      promising therapeutic strategy for HCC.
PG  - 1399-1407
LID - 10.2217/imt-2019-0081 [doi]
AB  - Background: Dendritic cells (DCs)-mediated immunotherapy has been considered as a 
      promising antitumor method. Aspartate-beta-hydroxylase (AAH) is a potential 
      immunotherapeutic target for hepatocellular carcinoma (HCC). Materials & methods: 
      C57BL/6 mice were immunized by AAH-DCs vaccine constructed ex vivo. Killing tumor 
      cells effect of active T cells induced by AAH-DCs vaccine on HCC cells were 
      measured in vitro and vivo. The underlying mechanism was preliminarily 
      investigated. Results: T cells response when activated by AAH-DCs vaccine showed 
      a significant inhibition effect on HCC cells in vitro and in tumor-bearing mice 
      models when compared with controls. Additionally, compared with the control 
      group, increased expressions of Caspase8, Caspase 3 and Bax, and declined 
      expression of Bcl-2 were observed in AAH-DCs vaccine group. Conclusion: AAH-DCs 
      vaccine could stimulate T cell responses against HCC, which was possibly achieved 
      via pro-apoptosis mechanism.
FAU - Zhou, Yujiao
AU  - Zhou Y
AUID- ORCID: 0000-0002-1397-1581
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Li, Chengmin
AU  - Li C
AD  - Department of Gastroenterology,The Third Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Shi, Guo
AU  - Shi G
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Xu, Xiaolei
AU  - Xu X
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Luo, Xue
AU  - Luo X
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Zhang, Yuanling
AU  - Zhang Y
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Fu, Jingjie
AU  - Fu J
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Chen, Limin
AU  - Chen L
AD  - Toronto General Research Institute, University of Toronto, Toronto, ON, M2J4A6, 
      Canada.
FAU - Zeng, Aizhong
AU  - Zeng A
AD  - Department of Infectious Disease, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191014
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Cancer Vaccines)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.11.- (aspartic acid 2-oxoglutarate-dependent dioxygenase)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/immunology
MH  - Cancer Vaccines/administration & dosage/*immunology
MH  - Carcinoma, Hepatocellular/enzymology/immunology/*therapy
MH  - Cell Line, Tumor
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Immunotherapy, Adoptive/*methods
MH  - Liver Neoplasms/enzymology/immunology/*therapy
MH  - Mice, Inbred C57BL
MH  - Mice, Nude
MH  - Mixed Function Oxygenases/antagonists & inhibitors/immunology/*metabolism
MH  - T-Lymphocytes/immunology
MH  - Xenograft Model Antitumor Assays/methods
OTO - NOTNLM
OT  - adoptive T-cell therapy
OT  - apoptosis
OT  - aspartate-beta-hydroxylase
OT  - dendritic cells
OT  - hepatocellular carcinoma
EDAT- 2019/10/15 06:00
MHDA- 2020/05/27 06:00
CRDT- 2019/10/15 06:00
PHST- 2019/10/15 06:00 [pubmed]
PHST- 2020/05/27 06:00 [medline]
PHST- 2019/10/15 06:00 [entrez]
AID - 10.2217/imt-2019-0081 [doi]
PST - ppublish
SO  - Immunotherapy. 2019 Nov;11(16):1399-1407. doi: 10.2217/imt-2019-0081. Epub 2019 
      Oct 14.