PMID- 31609027
OWN - NLM
STAT- MEDLINE
DCOM- 20200713
LR  - 20200713
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 36
IP  - 11
DP  - 2019 Nov
TI  - Improvements of right ventricular function and hemodynamics after balloon 
      pulmonary angioplasty in patients with chronic thromboembolic pulmonary 
      hypertension.
PG  - 2050-2056
LID - 10.1111/echo.14503 [doi]
AB  - PURPOSE: Right ventricular (RV) function is an important factor in the prognosis 
      of chronic thromboembolic pulmonary hypertension (CTEPH) in patients. In our 
      study, we aimed to evaluate the timing and magnitude of regional RV function 
      before and after balloon pulmonary angioplasty (BPA) using speckle tracking 
      echocardiography (STE) and their relation to clinical and hemodynamic parameters 
      in patients with CTEPH. MATERIAL AND METHOD: We enrolled 20 CTEPH patients and 19 
      healthy subjects in our study. Enrolled patients underwent echocardiography, 
      right heart catheterization (RHC), and 6-minute walk distance (6MWD) test at 
      baseline and after the BPA. RESULTS: In hemodynamic RHC measurements and clinical 
      evaluations, mean pulmonary artery pressure (median: 53.5 mm Hg vs 37.0 mm Hg, 
      P = .001) and pulmonary vascular resistance (median: 12 Wood units [WU] vs 7 WU, 
      P = .001) and pro-brain natriuretic peptide level decreased and 6MWD increased 
      after BPA sessions. There was no statistically significant difference between 
      before and after the BPA sessions in conventional echocardiographic measurements. 
      In STE analysis, the electromechanical delay (EMD) between RV free wall (RVF) and 
      LV lateral wall (LVL) (median: 65 ms vs 47.5 ms, P = .01) and RV peak systolic 
      strain dispersion index (52 ms vs 29 ms, P = .001) were higher in patients with 
      CTEPH than healthy controls before the BPA. Both these parameters decreased 
      significantly after BPA. CONCLUSION: Chronic thromboembolic pulmonary 
      hypertension was associated with RV electromechanical delay and dispersion based 
      on the STE analysis. Balloon pulmonary angioplasty might have an important impact 
      on the improvement of both RV function and hemodynamics.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Kanar, Batur Gonenc
AU  - Kanar BG
AUID- ORCID: 0000-0002-5156-0302
AD  - Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, 
      Turkey.
FAU - Mutlu, Bulent
AU  - Mutlu B
AD  - Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, 
      Turkey.
FAU - Atas, Halil
AU  - Atas H
AD  - Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, 
      Turkey.
FAU - Akaslan, Dursun
AU  - Akaslan D
AD  - Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, 
      Turkey.
FAU - Yildizeli, Bedrettin
AU  - Yildizeli B
AD  - Department of Chest Medicine Surgery, Faculty of Medicine, Marmara University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20191014
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Angioplasty, Balloon/*methods
MH  - Cardiac Catheterization
MH  - Echocardiography/*methods
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/etiology/*physiopathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prognosis
MH  - Pulmonary Artery/physiopathology/*surgery
MH  - Pulmonary Embolism/*complications/diagnosis/surgery
MH  - Vascular Resistance/physiology
MH  - Ventricular Function, Right/*physiology
OTO - NOTNLM
OT  - balloon pulmonary angioplasty
OT  - chronic thromboembolic pulmonary hypertension
OT  - echocardiography
OT  - electromechanical delay
OT  - strain
EDAT- 2019/10/15 06:00
MHDA- 2020/07/14 06:00
CRDT- 2019/10/15 06:00
PHST- 2019/05/16 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/10/15 06:00 [pubmed]
PHST- 2020/07/14 06:00 [medline]
PHST- 2019/10/15 06:00 [entrez]
AID - 10.1111/echo.14503 [doi]
PST - ppublish
SO  - Echocardiography. 2019 Nov;36(11):2050-2056. doi: 10.1111/echo.14503. Epub 2019 
      Oct 14.