PMID- 31609840
OWN - NLM
STAT- MEDLINE
DCOM- 20210923
LR  - 20210923
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Dec
TI  - Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen in 
      Children.
PG  - 498-503
LID - 10.1097/WNO.0000000000000845 [doi]
AB  - BACKGROUND: To assess the utility of enhanced depth imaging optical coherence 
      tomography (EDI-OCT), compared with other conventional imaging modalities, for 
      detecting and characterizing optic nerve head drusen (ONHD) in children. METHODS: 
      We report a retrospective cross-sectional case series of consecutive pediatric 
      patients (age </=16 years) with ONHD confirmed using B-scan ultrasonography. All 
      eyes were evaluated using spectral-domain OCT of the optic nerve head in 
      conventional (non-EDI) and EDI modes, fundus autofluorescence (FAF), and standard 
      automated perimetry. Detection rates and the capacity to characterize ONHD were 
      compared between EDI-OCT, non-EDI-OCT, and FAF. RESULTS: Twenty-eight eyes of 15 
      patients (mean age 11 years; 60% female) were identified with definite ONHD that 
      were confirmed by B-scan ultrasound. Among the technologies, EDI-OCT, 
      non-EDI-OCT, FAF, and automated perimetry had findings consistent with ONHD in 
      24, 21, 18, and 4 eyes, respectively. EDI-OCT had a significantly better 
      detection capability (86% of eyes) compared with FAF (P = 0.04) but not with 
      non-EDI-OCT (P = 0.15). Similar to results previously reported in adult patients, 
      EDI-OCT detected ONHD at different levels of depth; most were located anterior to 
      the lamina cribrosa. ONHD detected by EDI-OCT appeared as hypo-reflective ovoid 
      regions bordered by hyper-reflective material or as isolated hyper-reflective 
      bands without a hypo-reflective core. The mean greatest diameter of ONHD seen on 
      EDI-OCT was 449.7 (SD +/-114.1) mum. CONCLUSIONS: EDI-OCT detects ONHD in most eyes 
      identified as having drusen on B-scan ultrasonography. This technique has the 
      potential to be an effective alternative first-line diagnostic and monitoring 
      tool for ONHD, particularly for detecting buried drusen in children.
FAU - Sim, Peng Yong
AU  - Sim PY
AD  - Ophthalmology Department, Watford General Hospital, Watford, United Kingdom.
FAU - Soomro, Hibba
AU  - Soomro H
FAU - Karampelas, Michael
AU  - Karampelas M
FAU - Barampouti, Faye
AU  - Barampouti F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*diagnostic imaging
MH  - Optic Disk Drusen/*diagnosis/physiopathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Visual Fields/*physiology
EDAT- 2019/10/15 06:00
MHDA- 2021/09/24 06:00
CRDT- 2019/10/15 06:00
PHST- 2019/10/15 06:00 [pubmed]
PHST- 2021/09/24 06:00 [medline]
PHST- 2019/10/15 06:00 [entrez]
AID - 00041327-202012000-00008 [pii]
AID - 10.1097/WNO.0000000000000845 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2020 Dec;40(4):498-503. doi: 10.1097/WNO.0000000000000845.