PMID- 31610625
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1598-866X (Print)
IS  - 2234-0742 (Electronic)
IS  - 1598-866X (Linking)
VI  - 17
IP  - 3
DP  - 2019 Sep
TI  - Analysis of differences in human leukocyte antigen between the two Wellcome Trust 
      Case Control Consortium control datasets.
PG  - e29
LID - 10.5808/GI.2019.17.3.e29 [doi]
LID - e29
AB  - The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide 
      association study that aimed to identify common variants associated with seven 
      diseases. That study combined two control datasets (58C and UK Blood Services) as 
      shared controls. Prior to using the combined controls, the WTCCC performed 
      analyses to show that the genomic content of the control datasets was not 
      significantly different. Recently, the analysis of human leukocyte antigen (HLA) 
      genes has become prevalent due to the development of HLA imputation technology. 
      In this project, we extended the between-control homogeneity analysis of the 
      WTCCC to HLA. We imputed HLA information in the WTCCC control dataset and showed 
      that the HLA content was not significantly different between the two control 
      datasets, suggesting that the combined controls can be used as controls for HLA 
      fine-mapping analysis based on HLA imputation.
FAU - Jang, Chloe Soohyun
AU  - Jang CS
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, Korea.
FAU - Choi, Wanson
AU  - Choi W
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, Korea.
FAU - Cook, Seungho
AU  - Cook S
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, Korea.
FAU - Han, Buhm
AU  - Han B
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, Korea.
LA  - eng
GR  - Seoul National University Hospital/
PT  - Journal Article
DEP - 20190927
PL  - Korea (South)
TA  - Genomics Inform
JT  - Genomics & informatics
JID - 101223836
PMC - PMC6808636
OTO - NOTNLM
OT  - genome-wide association study
OT  - human leukocyte antigen
OT  - shared control
COIS- Conflicts of Interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2019/10/15 06:00
MHDA- 2019/10/15 06:01
PMCR- 2019/09/01
CRDT- 2019/10/15 06:00
PHST- 2019/04/01 00:00 [received]
PHST- 2019/08/30 00:00 [accepted]
PHST- 2019/10/15 06:00 [entrez]
PHST- 2019/10/15 06:00 [pubmed]
PHST- 2019/10/15 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - GI.2019.17.3.e29 [pii]
AID - gi-2019-17-3-e29 [pii]
AID - 10.5808/GI.2019.17.3.e29 [doi]
PST - ppublish
SO  - Genomics Inform. 2019 Sep;17(3):e29. doi: 10.5808/GI.2019.17.3.e29. Epub 2019 Sep 
      27.