PMID- 31610769
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 24
IP  - 10
DP  - 2021 Oct
TI  - Gestational caloric restriction with micronutrients supplementation does not 
      delay development and promotes feeding behavior benefits.
PG  - 770-780
LID - 10.1080/1028415X.2019.1676972 [doi]
AB  - Introduction: Caloric restriction (CR) has been proven to promote a series of 
      health benefits from yeast to primates. Nowadays, increasing rates of obesity 
      certainly encourage researchers to evaluate CR effects and establish it as a 
      therapeutic approach. Maternal obesity is also a concern, and studies in the 
      developmental origins of health and disease (DOHaD) have shown the importance of 
      interventions during pregnancy, especially those involving maternal nutrition. On 
      the other hand, undernutrition during pregnancy leads to increased weight gain, 
      disturbed feeding behavior and dysfunctional metabolism in adulthood.Methods: In 
      this way, we utilized moderate CR (20% compared to control consumption) in 
      pregnant Wistar rats as intervention, with malnutrition control by micronutrients 
      supplementation. We assessed CR effects on offspring's developmental milestones, 
      feeding behavior, exploratory behavior, and memory on adolescence (PND21) and 
      adulthood (PND60).Results: We did not find alterations on litter size or birth 
      weight, although CR pups were leaner at adult ages. Importantly, no delay in 
      development was observed. Besides, female pups showed earlier suction reflex and 
      male pups showed earlier response to the negative geotaxis. CR pups also showed 
      less preference for palatable food (Froot Loops(R)) at adult age, which could be 
      decisive on obesity tendency. Locomotor activity was increased by CR on PND60 and 
      there was no effect on memory at all.Discussion: Our results on development and 
      behavior demonstrate that gestational CR may be a helpful health strategy if 
      malnutrition is well controlled, with potential clinical impact.
FAU - Stone, Vinicius
AU  - Stone V
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Maurmann, Rafael Moura
AU  - Maurmann RM
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Dal Magro, Barbara Marino
AU  - Dal Magro BM
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Crestani, Mariana Scortegagna
AU  - Crestani MS
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Hozer, Regis Matheus
AU  - Hozer RM
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Klein, Caroline Peres
AU  - Klein CP
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Matte, Cristiane
AU  - Matte C
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Fisiologia, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua 
      Sarmento Leite, 500, CEP 90050-170, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20191014
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Micronutrients)
SB  - IM
MH  - Adult
MH  - Animals
MH  - *Caloric Restriction
MH  - Dietary Supplements
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Male
MH  - Micronutrients
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Dietary restriction
OT  - behavior
OT  - developmental milestone
OT  - feeding behavior
OT  - intrauterine environment
OT  - malnutrition prevention
OT  - nutrition
OT  - pregnancy
EDAT- 2019/10/16 06:00
MHDA- 2022/04/01 06:00
CRDT- 2019/10/16 06:00
PHST- 2019/10/16 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2019/10/16 06:00 [entrez]
AID - 10.1080/1028415X.2019.1676972 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2021 Oct;24(10):770-780. doi: 10.1080/1028415X.2019.1676972. Epub 
      2019 Oct 14.