PMID- 31612146
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20220410
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2019
DP  - 2019
TI  - Cigarette Smoking Is Negatively Associated with the Prevalence of Type 2 Diabetes 
      in Middle-Aged Men with Normal Weight but Positively Associated with Stroke in 
      Men.
PG  - 1853018
LID - 10.1155/2019/1853018 [doi]
LID - 1853018
AB  - BACKGROUND: The prevalence of diabetes and potentially related complications, 
      including stroke, is rapidly increasing in China. The long-term effects of 
      lifestyle may affect glucose metabolism in the general population. Although some 
      studies have shown an association between smoking and the risk of type 2 diabetes 
      mellitus (T2DM), the relationship remains unclear. Furthermore, the relationship 
      between smoking and stroke in patients with T2DM has not been fully elucidated. 
      OBJECTIVE: We investigated the influence of cigarette smoking on T2DM and stroke 
      in China. Detailed questionnaires about smoking status and anthropometric 
      measurement were completed by participants, and oral glucose tolerance testing 
      (OGTT), hemoglobin A1c (HbA1c), homeostasis model assessment of IR (HOMA-IR), and 
      blood lipids were measured. RESULTS: In total, 8196 adults aged 40 years or older 
      were included. We found a reduced risk of impaired glucose regulation (IGR) and 
      T2DM in male smokers with normal weight (body mass index (BMI) < 25 kg/m(2) or 
      waist circumference (WC) < 90 cm) compared with nonsmokers after adjusting for 
      age, alcohol intake, physical activity, educational level, family history of 
      diabetes, SBP, DBP, TG, TC, HDL-C, and LDL-C. However, no significant association 
      was detected in male current smokers with overweight/obesity or female smokers. 
      In addition, compared with nonsmokers without T2DM, current smokers with T2DM had 
      a significantly higher risk of stroke (odds ratio: 2.64, 95% confidence interval: 
      1.25-5.57; P = 0.011) after adjusting for confounders. CONCLUSIONS: Smoking was 
      negatively associated with T2DM in Chinese men of normal body weight, but no 
      significant association was found for men with overweight/obesity or women. In 
      addition, smoking was positively associated with nonfatal stroke, especially in 
      patients with T2DM. Further prospective studies are needed to examine the 
      association between smoking, diabetes, and stroke in different ethnic groups.
CI  - Copyright (c) 2019 Su Wang et al.
FAU - Wang, Su
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Jiangning Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese 
      and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Wang, Yuzhong
AU  - Wang Y
AD  - Department of Geriatrics, Affiliated Jiangning Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yang, Yu
AU  - Yang Y
AD  - Department of Endocrinology, Affiliated Jiangning Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhang, Danyu
AU  - Zhang D
AD  - Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese 
      and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Liu, Chao
AU  - Liu C
AUID- ORCID: 0000-0002-3643-3903
AD  - Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese 
      and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Wang, Kun
AU  - Wang K
AUID- ORCID: 0000-0003-1142-0900
AD  - Department of Endocrinology, Affiliated Jiangning Hospital of Nanjing Medical 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20190911
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Adiposity
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cigarette Smoking/*adverse effects/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/diagnosis/epidemiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Stroke/diagnosis/*epidemiology
PMC - PMC6755302
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2019/10/16 06:00
MHDA- 2020/04/14 06:00
PMCR- 2019/09/11
CRDT- 2019/10/16 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/08/05 00:00 [revised]
PHST- 2019/08/23 00:00 [accepted]
PHST- 2019/10/16 06:00 [entrez]
PHST- 2019/10/16 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/09/11 00:00 [pmc-release]
AID - 10.1155/2019/1853018 [doi]
PST - epublish
SO  - J Diabetes Res. 2019 Sep 11;2019:1853018. doi: 10.1155/2019/1853018. eCollection 
      2019.