PMID- 31612225 OWN - NLM STAT- MEDLINE DCOM- 20210312 LR - 20210312 IS - 1537-6591 (Electronic) IS - 1058-4838 (Linking) VI - 71 IP - 2 DP - 2020 Jul 11 TI - Reaching the Second and Third Joint United Nations Programme on HIV/AIDS 90-90-90 Targets Is Accompanied by a Dramatic Reduction in Primary Human Immunodeficiency Virus (HIV) Infection and in Recent HIV Infections in a Large French Nationwide HIV Cohort. PG - 293-300 LID - 10.1093/cid/ciz800 [doi] AB - BACKGROUND: In late 2013, France was one of the first countries to recommend initiation of combination antiretroviral therapy (cART) irrespective of CD4 cell count. METHODS: To assess the impact of achieving the second and third Joint United Nations Programme on HIV/AIDS 90-90-90 targets (ie, 90% of diagnosed people on sustained cART, and, of those, 90% virologically controlled) on human immunodeficiency virus (HIV) incidence, we conducted a longitudinal study to describe the epidemiology of primary HIV infection (PHI) and/or recent HIV infection (patients with CD4 cell count >/=500/mm3 at HIV diagnosis; (PRHI) between 2007 and 2017 in a large French multicenter cohort. To identify changes in trends in PHI and PRHI, we used single breakpoint linear segmented regression analysis. RESULTS: During the study period, 61 822 patients were followed in the Dat'AIDS cohort; 2027 (10.0%) had PHI and 7314 (36.1%) had PRHI. The second and third targets were reached in 2014 and 2013, respectively. The median delay between HIV diagnosis and cART initiation decreased from 9.07 (interquartile range [IQR], 1.39-33.47) months in 2007 to 0.77 (IQR, 0.37-1.60) months in 2017. A decrease in PHI (-35.1%) and PRHI (-25.4%) was observed starting in 2013. The breakpoints for PHI and PRHI were 2012.6 (95% confidence interval [CI], 2010.8-2014.4) and 2013.1 (95% CI, 2011.3-2014.8), respectively. CONCLUSIONS: Our findings show that the achievements of 2 public health targets in France and the early initiation of cART were accompanied by a reduction of about one-third in PHI and PRHI between 2013 and 2017. CLINICAL TRIALS REGISTRATION: NCT02898987. CI - (c) The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. FAU - Le Guillou, Adrien AU - Le Guillou A AD - Department of Research and Public Health, Reims Teaching Hospitals, Robert Debre Hospital, Reims, France. FAU - Pugliese, Pascal AU - Pugliese P AD - Department of Infectious Diseases, Universite Cote d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France. FAU - Raffi, Francois AU - Raffi F AD - Department of Infectious Diseases, CHU de Nantes and CIC 1413, INSERM; Universite de Nantes, Nantes, France. FAU - Cabie, Andre AU - Cabie A AD - Department of Infectious Diseases, University Hospital of Martinique, INSERM CIC 1424, Martinique, France. FAU - Cuzin, Lise AU - Cuzin L AD - Department of Infectious Diseases; University Hospital of Martinique, Martinique; INSERM UMR 1027, Toulouse, France. FAU - Katlama, Christine AU - Katlama C AD - Department of Infectious Diseases, Hopital Pitie Salpetriere, Assistance Publique des Hopitaux de Paris, Paris, France. FAU - Allavena, Clotilde AU - Allavena C AD - Department of Infectious Diseases, CHU de Nantes and CIC 1413, INSERM; Universite de Nantes, Nantes, France. FAU - Drame, Moustapha AU - Drame M AD - Department of Research and Public Health, Reims Teaching Hospitals, Robert Debre Hospital, Reims, France. AD - Department of Clinical Research and Innovation, University Hospitals of Martinique, Martinique, France. FAU - Cotte, Laurent AU - Cotte L AD - Department of Infectious Diseases, Croix-Rousse Hospital, Hospices Civils de Lyon, and INSERM U1052, Lyon, France. FAU - Bani-Sadr, Firouze AU - Bani-Sadr F AD - Department of Internal Medicine, Clinical Immunology and Infectious Diseases, University Hospital, Reims, France. AD - University of Reims Champagne-Ardenne, EA-4684/SFR CAP-SANTE, Reims, France. CN - Dat'AIDS Study Group LA - eng SI - ClinicalTrials.gov/NCT02898987 PT - Journal Article PT - Multicenter Study PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 SB - IM CIN - Clin Infect Dis. 2020 Jul 11;71(2):301-303. PMID: 31420643 MH - CD4 Lymphocyte Count MH - France/epidemiology MH - HIV MH - *HIV Infections/drug therapy/epidemiology MH - Humans MH - Longitudinal Studies MH - United Nations OTO - NOTNLM OT - 90-90-90 target OT - Dat'AIDS cohort OT - TasP OT - cascade of care OT - primary HIV infection FIR - Orticoni, M IR - Orticoni M FIR - Soavi, M J IR - Soavi MJ FIR - Luquet-Besson, I IR - Luquet-Besson I FIR - Ressiot, E IR - Ressiot E FIR - Carta-Padovani, M IR - Carta-Padovani M FIR - Ducassou, M J IR - Ducassou MJ FIR - Bertone, H IR - Bertone H FIR - Galie, S IR - Galie S FIR - Galinier, A IR - Galinier A FIR - Monclar, M IR - Monclar M FIR - Ritleng, A S IR - Ritleng AS FIR - Ivanova, A IR - Ivanova A FIR - Blanco-Betancourt, C IR - Blanco-Betancourt C FIR - Lions, C IR - Lions C FIR - Poizot-Martin, I IR - Poizot-Martin I FIR - Dhiver, C IR - Dhiver C FIR - Saadia Mokhtari, M IR - Saadia Mokhtari M FIR - Menard, A IR - Menard A FIR - Tissot Dupont, H IR - Tissot Dupont H FIR - Tomei, C IR - Tomei C FIR - Meddeb, L IR - Meddeb L FIR - Belkhir, A Y IR - Belkhir AY FIR - Ravaux, I IR - Ravaux I FIR - Alvarez, M IR - Alvarez M FIR - Biezunski, N IR - Biezunski N FIR - Debard, A IR - Debard A FIR - Delpierre, C IR - Delpierre C FIR - Lansalot, P IR - Lansalot P FIR - Lelievre, L IR - Lelievre L FIR - Martin-Blondel, G IR - Martin-Blondel G FIR - Piffaut, M IR - Piffaut M FIR - Porte, L IR - Porte L FIR - Saune, K IR - Saune K FIR - Delobel, P IR - Delobel P FIR - Pugliese, P IR - Pugliese P FIR - Breaud, S IR - Breaud S FIR - Ceppi, C IR - Ceppi C FIR - Chirio, D IR - Chirio D FIR - Cua, E IR - Cua E FIR - Dellamonica, P IR - Dellamonica P FIR - Demonchy, E IR - Demonchy E FIR - De Monte, A IR - De Monte A FIR - Durant, J IR - Durant J FIR - Etienne, C IR - Etienne C FIR - Ferrando, S IR - Ferrando S FIR - Garraffo, R IR - Garraffo R FIR - Michelangeli, C IR - Michelangeli C FIR - Mondain, V IR - Mondain V FIR - Allavena, C IR - Allavena C FIR - Bernaud, C IR - Bernaud C FIR - Billaud, E IR - Billaud E FIR - Biron, C IR - Biron C FIR - Bonnet, B IR - Bonnet B FIR - Bouchez, S IR - Bouchez S FIR - Boutoille, D IR - Boutoille D FIR - Brunet-Cartier, C IR - Brunet-Cartier C FIR - Deschanvres, C IR - Deschanvres C FIR - Gaborit, B IR - Gaborit B FIR - Hall, N IR - Hall N FIR - Jovelin, T IR - Jovelin T FIR - Le Turnier, P IR - Le Turnier P FIR - Morineau, P IR - Morineau P FIR - Reliquet, V IR - Reliquet V FIR - Secher, S IR - Secher S FIR - Cavellec, M IR - Cavellec M FIR - Soria, A IR - Soria A FIR - Ferre, V IR - Ferre V FIR - Andre-Garnier, E IR - Andre-Garnier E FIR - Rodallec, A IR - Rodallec A FIR - Lefebvre, M IR - Lefebvre M FIR - Grossi, O IR - Grossi O FIR - Aubry, O IR - Aubry O FIR - Raffi, F IR - Raffi F FIR - Amazzough, K IR - Amazzough K FIR - Benabdelmoumen, G IR - Benabdelmoumen G FIR - Bossi, P IR - Bossi P FIR - Cessot, G IR - Cessot G FIR - Charlier, C IR - Charlier C FIR - Consigny, P H IR - Consigny PH FIR - Danion, F IR - Danion F FIR - Dureault, A IR - Dureault A FIR - Duvivier, C IR - Duvivier C FIR - Goesch, J IR - Goesch J FIR - Guery, R IR - Guery R FIR - Henry, B IR - Henry B FIR - Jidar, K IR - Jidar K FIR - Lanternier, F IR - Lanternier F FIR - Loubet, P IR - Loubet P FIR - Lortholary, O IR - Lortholary O FIR - Louisin, C IR - Louisin C FIR - Lourenco, J IR - Lourenco J FIR - Parize, P IR - Parize P FIR - Pilmis, B IR - Pilmis B FIR - Touam, F IR - Touam F FIR - Valantin, M A IR - Valantin MA FIR - Tubiana, R IR - Tubiana R FIR - Agher, R IR - Agher R FIR - Seang, S IR - Seang S FIR - Schneider, L IR - Schneider L FIR - PaLich, R IR - PaLich R FIR - Blanc, C IR - Blanc C FIR - Katlama, C IR - Katlama C FIR - Cabie, A IR - Cabie A FIR - Cuzin, L IR - Cuzin L FIR - Abel, S IR - Abel S FIR - Pierre-Francois, S IR - Pierre-Francois S FIR - Pasquier, J IR - Pasquier J FIR - Guitteaud, K IR - Guitteaud K FIR - Turmel, J M IR - Turmel JM FIR - Illiaquer, M IR - Illiaquer M FIR - Fischer, P IR - Fischer P FIR - Partisani, M IR - Partisani M FIR - Cheneau, C IR - Cheneau C FIR - Priester, M IR - Priester M FIR - Batard, M L IR - Batard ML FIR - Bernard-Henry, C IR - Bernard-Henry C FIR - de Mautort, E IR - de Mautort E FIR - Fafi-Kremer, S IR - Fafi-Kremer S FIR - Rey, D IR - Rey D FIR - Chirouze, C IR - Chirouze C FIR - Gardiennet, Q IR - Gardiennet Q FIR - Bani-Sadr, F IR - Bani-Sadr F FIR - Berger, J L IR - Berger JL FIR - N'Guyen, Y IR - N'Guyen Y FIR - Lambert, D IR - Lambert D FIR - Hentzien, M IR - Hentzien M FIR - Lebrun, D IR - Lebrun D FIR - Brunet, A IR - Brunet A FIR - Kmiec, I IR - Kmiec I FIR - Brodard, V IR - Brodard V FIR - Cotte, L IR - Cotte L FIR - Chidiac, C IR - Chidiac C FIR - Ferry, T IR - Ferry T FIR - Ader, F IR - Ader F FIR - Biron, F IR - Biron F FIR - Boibieux, A IR - Boibieux A FIR - Miailhes, P IR - Miailhes P FIR - Perpoint, T IR - Perpoint T FIR - Schlienger, I IR - Schlienger I FIR - Lippmann, J IR - Lippmann J FIR - Braun, E IR - Braun E FIR - Koffi, J IR - Koffi J FIR - Longuet, C IR - Longuet C FIR - Gueripel, V IR - Gueripel V FIR - Augustin-Normand, C IR - Augustin-Normand C FIR - Brochier, C IR - Brochier C FIR - Degroodt, S IR - Degroodt S FIR - Atoui, N IR - Atoui N FIR - Le Moing, V IR - Le Moing V FIR - Makinson, A IR - Makinson A FIR - Meftah, N IR - Meftah N FIR - de Boever, C Merle IR - de Boever CM FIR - Montes, B IR - Montes B FIR - Montoya Ferrer, A IR - Montoya Ferrer A FIR - Reynes, J IR - Reynes J FIR - Andre, M IR - Andre M FIR - Boyer, L IR - Boyer L FIR - Bouillon, M P IR - Bouillon MP FIR - Delestan, M IR - Delestan M FIR - May, T IR - May T FIR - Hocqueloux, L IR - Hocqueloux L FIR - Prazuck, T IR - Prazuck T FIR - Gubavu, C IR - Gubavu C FIR - Seve, A IR - Seve A FIR - Maka, A IR - Maka A FIR - Boulard, C IR - Boulard C FIR - Thomas, G IR - Thomas G FIR - Cheret, A IR - Cheret A FIR - Goujard, C IR - Goujard C FIR - Quertainmont, Y IR - Quertainmont Y FIR - Teicher, E IR - Teicher E FIR - Lerolle, N IR - Lerolle N FIR - Deradji, O IR - Deradji O FIR - Barrail-Tran, A IR - Barrail-Tran A FIR - Landman, R IR - Landman R FIR - Joly, V IR - Joly V FIR - Rioux, C IR - Rioux C FIR - Lariven, S IR - Lariven S FIR - Gervais, A IR - Gervais A FIR - Lescure, F X IR - Lescure FX FIR - Matheron, S IR - Matheron S FIR - Louni, F IR - Louni F FIR - Godard, C IR - Godard C FIR - Julia, Z IR - Julia Z FIR - Chansombat, M IR - Chansombat M FIR - Rahli, D IR - Rahli D FIR - Mackoumbou-Nkouka, C IR - Mackoumbou-Nkouka C FIR - Charpentier, C IR - Charpentier C FIR - Descamps, D IR - Descamps D FIR - Peytavin, G IR - Peytavin G FIR - Yazdanpanah, Y IR - Yazdanpanah Y FIR - Tattevin, P IR - Tattevin P FIR - Revest, M IR - Revest M FIR - Souala, F IR - Souala F FIR - Baldeyrou, M IR - Baldeyrou M FIR - Patrat-Delon, S IR - Patrat-Delon S FIR - Chapplain, J M IR - Chapplain JM FIR - Benezit, F IR - Benezit F FIR - Dupont, M IR - Dupont M FIR - Poinot, M IR - Poinot M FIR - Maillard, A IR - Maillard A FIR - Pronier, C IR - Pronier C FIR - Lemaitre, F IR - Lemaitre F FIR - Guennoun, C IR - Guennoun C FIR - Poisson-Vanier, M IR - Poisson-Vanier M FIR - Jovelin, T IR - Jovelin T FIR - Sinteff, J P IR - Sinteff JP FIR - Arvieux, C IR - Arvieux C FIR - Botelho-Nevers, E IR - Botelho-Nevers E FIR - Gagneux-Brunon, A IR - Gagneux-Brunon A FIR - Fresard, A IR - Fresard A FIR - Lucht, F IR - Lucht F FIR - Ajana, F IR - Ajana F FIR - Aissi, E IR - Aissi E FIR - Alcaraz, I IR - Alcaraz I FIR - Baclet, V IR - Baclet V FIR - Bocket, L IR - Bocket L FIR - Boucher, A IR - Boucher A FIR - Choisy, P IR - Choisy P FIR - Huleux, T IR - Huleux T FIR - Lafon-Desmurs, B IR - Lafon-Desmurs B FIR - Meybeck, A IR - Meybeck A FIR - Pradier, M IR - Pradier M FIR - Robineau, O IR - Robineau O FIR - Viget, N IR - Viget N FIR - Valette, M IR - Valette M FIR - Hoen, B IR - Hoen B FIR - Lamaury, I IR - Lamaury I FIR - Fabre, I IR - Fabre I FIR - Curlier, E IR - Curlier E FIR - Ouissa, R IR - Ouissa R FIR - Schepers, K IR - Schepers K FIR - Herrmann-Storck, C IR - Herrmann-Storck C FIR - Dournon, N IR - Dournon N FIR - Merrien, D IR - Merrien D FIR - Perre, P IR - Perre P FIR - Guimard, T IR - Guimard T FIR - Bollangier, O IR - Bollangier O FIR - Leautez, S IR - Leautez S FIR - Morrier, M IR - Morrier M EDAT- 2019/10/16 06:00 MHDA- 2021/03/13 06:00 CRDT- 2019/10/16 06:00 PHST- 2019/03/28 00:00 [received] PHST- 2019/08/16 00:00 [accepted] PHST- 2019/10/16 06:00 [pubmed] PHST- 2021/03/13 06:00 [medline] PHST- 2019/10/16 06:00 [entrez] AID - 5550908 [pii] AID - 10.1093/cid/ciz800 [doi] PST - ppublish SO - Clin Infect Dis. 2020 Jul 11;71(2):293-300. doi: 10.1093/cid/ciz800.