PMID- 31614323
OWN - NLM
STAT- MEDLINE
DCOM- 20200807
LR  - 20200807
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 54
DP  - 2019 Dec
TI  - Managing the Alpha-1 patient in the ICU: Adapting broad critical care strategies 
      in AATD.
PG  - 212-219
LID - S0883-9441(19)30076-0 [pii]
LID - 10.1016/j.jcrc.2019.08.027 [doi]
AB  - Alpha-1 Antitrypsin Deficiency (AATD) is a progressive pulmonary disease 
      under-recognized or misdiagnosed by clinicians. Patients with AATD can develop a 
      variety of organ-specific complications and as a result, often require 
      hospitalization and treatment within critical care and ICU settings. Due to the 
      complexity of AATD there are minimal guidelines in place to address the specific 
      and highly variable needs of these patients in the critical care setting. This 
      review presents clinical considerations with respect to the management of 
      patients with AATD and provides treatment recommendations for these patients in 
      the critical care setting. In addition, we have outlined certain aspects of the 
      care of this patient population that may be of interest to critical care 
      practitioners. With greater disease awareness and earlier diagnosis the onset of 
      symptoms can be delayed, which will ultimately reduce the frequency of 
      deleterious health consequences.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Rahaghi, Franck
AU  - Rahaghi F
AD  - Pulmonary and Critical Care Division, Cleveland Clinic Florida, Weston, Florida, 
      United States. Electronic address: rahaghf@ccf.org.
FAU - Omert, Laurel
AU  - Omert L
AD  - CSL Behring, King of Prussia, PA, United States. Electronic address: 
      Laurel.Omert@cslbehring.com.
FAU - Clark, Virginia
AU  - Clark V
AD  - Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, 
      Gainesville, Florida, United States. Electronic address: 
      Virginia.Clark@medicine.ufl.edu.
FAU - Sandhaus, Robert A
AU  - Sandhaus RA
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, 
      Denver, CO, United States. Electronic address: RSandhaus@alphanet.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190829
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
MH  - Clinical Protocols
MH  - Critical Care
MH  - Humans
MH  - Intensive Care Units
MH  - Pulmonary Disease, Chronic Obstructive/complications/*therapy
MH  - alpha 1-Antitrypsin Deficiency/complications/*therapy
OTO - NOTNLM
OT  - Alpha-1 Antitrypsin Deficiency
OT  - Cardiovascular disease
OT  - Critical care
OT  - Intensive care unit
OT  - Liver disease
OT  - Pulmonary disease, chronic obstructive
EDAT- 2019/10/16 06:00
MHDA- 2020/08/08 06:00
CRDT- 2019/10/16 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/07/17 00:00 [revised]
PHST- 2019/08/27 00:00 [accepted]
PHST- 2019/10/16 06:00 [pubmed]
PHST- 2020/08/08 06:00 [medline]
PHST- 2019/10/16 06:00 [entrez]
AID - S0883-9441(19)30076-0 [pii]
AID - 10.1016/j.jcrc.2019.08.027 [doi]
PST - ppublish
SO  - J Crit Care. 2019 Dec;54:212-219. doi: 10.1016/j.jcrc.2019.08.027. Epub 2019 Aug 
      29.