PMID- 31614327
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200113
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 255
IP  - Pt 2
DP  - 2019 Dec
TI  - Association between exposure to arsenic, nickel, cadmium, selenium, and zinc and 
      fasting blood glucose levels.
PG  - 113325
LID - S0269-7491(19)33795-9 [pii]
LID - 10.1016/j.envpol.2019.113325 [doi]
AB  - Associations between single metal and fasting blood glucose (FBG) levels have 
      been reported in previous studies. However, the association between multi-metals 
      exposure and FBG level are little known. To assess the joints of arsenic (As), 
      nickel (Ni), cadmium (Cd), selenium (Se), and zinc (Zn) co-exposure on FBG 
      levels, Bayesian kernel machine regression (BKMR) statistical method was used to 
      estimate the potential joint associations between As, Ni, Cd, Se, and Zn 
      co-exposure and FBG levels among 1478 community-based Chinese adults from two 
      counties, Shimen (n = 696) and Huayuan (n = 782), with different exposure 
      profiles in Hunan province of China. The metals levels were measured in spot 
      urine (As, Ni, and Cd) and plasma (Se and Zn) using inductively coupled 
      plasma-mass spectrometry, respectively. The exposure levels of all the five 
      metals were significantly higher in Shimen area (median: As = 57.76 mug/L, 
      Cd = 2.75 mug/L, Ni = 2.73 mug/L, Se = 112.67 mug/L, Zn = 905.68 mug/L) than those in 
      Huayuan area (As = 41.14 mug/L, Cd = 2.22 mug/L, Ni = 1.88 mug/L, Se = 65.59 mug/L, 
      Zn = 819.18 mug/L). The BKMR analyses showed a significantly positive over-all 
      effect of the five metals on FBG levels when metals concentrations were all above 
      the 50th percentile while a statistically negative over-all effect when metals 
      concentrations were all under the 50th percentile in Shimen area. However, a 
      totally opposite over-all effect of the mixture of the five metals on FBG levels 
      was found in Huayuan area. BKMR also revealed a non-linear exposure-effect of Zn 
      on FBG levels in Huayuan area. In addition, interaction effects of As and Se on 
      FBG level were observed. The relationship between single or combined metals 
      exposure and FBG was different against different exposure profiles. Potential 
      interaction effects of As and Se on FBG levels may exist.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Li, Zhaoyang
AU  - Li Z
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Xu, Yali
AU  - Xu Y
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Huang, Zhijun
AU  - Huang Z
AD  - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China.
FAU - Wei, Yue
AU  - Wei Y
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Hou, Jian
AU  - Hou J
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China; 
      Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, 450001, China.
FAU - Long, Tengfei
AU  - Long T
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Hu, Hua
AU  - Hu H
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Duan, Yanying
AU  - Duan Y
AD  - Department of Occupational and Environmental Health, Xiangya School of Public 
      Health, Central South University, Changsha, 410078, China.
FAU - Guo, Huan
AU  - Guo H
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Zhang, Xiaomin
AU  - Zhang X
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Chen, Xiang
AU  - Chen X
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410008, China.
FAU - Yuan, Hong
AU  - Yuan H
AD  - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China.
FAU - Wu, Tangchun
AU  - Wu T
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Shen, Minxue
AU  - Shen M
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410008, China. Electronic address: shenmx1988@csu.edu.cn.
FAU - He, Meian
AU  - He M
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, 430030, China. 
      Electronic address: hemeian@hust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191005
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Blood Glucose)
RN  - 0 (Metals, Heavy)
RN  - 00BH33GNGH (Cadmium)
RN  - 7OV03QG267 (Nickel)
RN  - H6241UJ22B (Selenium)
RN  - J41CSQ7QDS (Zinc)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arsenic/*urine
MH  - Bayes Theorem
MH  - Blood Glucose/*drug effects
MH  - Cadmium/*urine
MH  - China
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Metals, Heavy/toxicity
MH  - Middle Aged
MH  - Nickel/*urine
MH  - Selenium/*blood
MH  - Young Adult
MH  - Zinc/*blood
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Fasting blood glucose
OT  - Joint exposure
OT  - Metal
EDAT- 2019/10/16 06:00
MHDA- 2020/01/14 06:00
CRDT- 2019/10/16 06:00
PHST- 2019/07/13 00:00 [received]
PHST- 2019/09/08 00:00 [revised]
PHST- 2019/09/28 00:00 [accepted]
PHST- 2019/10/16 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/10/16 06:00 [entrez]
AID - S0269-7491(19)33795-9 [pii]
AID - 10.1016/j.envpol.2019.113325 [doi]
PST - ppublish
SO  - Environ Pollut. 2019 Dec;255(Pt 2):113325. doi: 10.1016/j.envpol.2019.113325. 
      Epub 2019 Oct 5.