PMID- 31614523
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 10
DP  - 2019 Oct 11
TI  - New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe 
      Aortic Regurgitation.
LID - 10.3390/jcm8101654 [doi]
LID - 1654
AB  - Background: Determining the value of new imaging markers to predict aortic valve 
      (AV) surgery in asymptomatic patients with severe aortic regurgitation (AR) in a 
      prospective, observational, multicenter study. Methods: Consecutive patients with 
      chronic severe AR were enrolled between 2015-2018. Baseline examination included 
      echocardiography (ECHO) with 2- and 3-dimensional (2D and 3D) vena contracta area 
      (VCA), and magnetic resonance imaging (MRI) with regurgitant volume (RV) and 
      fraction (RF) analyzed in CoreLab. Results: The mean follow-up was 587 days 
      (interquartile range (IQR) 296-901) in a total of 104 patients. Twenty patients 
      underwent AV surgery. Baseline clinical and laboratory data did not differ 
      between surgically and medically treated patients. Surgically treated patients 
      had larger left ventricular (LV) dimension, end-diastolic volume (all p < 0.05), 
      and the LV ejection fraction was similar. The surgical group showed higher 
      prevalence of severe AR (70% vs. 40%, p = 0.02). Out of all imaging markers 3D 
      VCA, MRI-derived RV and RF were identified as the strongest independent 
      predictors of AV surgery (all p < 0.001). Conclusions: Parameters related to LV 
      morphology and function showed moderate accuracy to identify patients in need of 
      early AV surgery at the early stage of the disease. 3D ECHO-derived VCA and 
      MRI-derived RV and RF showed high accuracy and excellent sensitivity to identify 
      patients in need of early surgery.
FAU - Kockova, Radka
AU  - Kockova R
AUID- ORCID: 0000-0002-6645-0245
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague 14021, Czech Republic. radka.kockova@ikem.cz.
AD  - Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, Hradec 
      Kralove 500 03, Czech Republic. radka.kockova@ikem.cz.
FAU - Linkova, Hana
AU  - Linkova H
AD  - Department of Cardiology, Royal Vinohrady University Hospital, Prague 10034, 
      Czech Republic. hana.linkova@fnkv.cz.
FAU - Hlubocka, Zuzana
AU  - Hlubocka Z
AD  - Department of Cardiology, General University Hospital, Prague 12808, Czech 
      Republic. zuzana.hlubocka@vfn.cz.
FAU - Praveckova, Alena
AU  - Praveckova A
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague 14021, Czech Republic. alena.praveckova@ikem.cz.
FAU - Polednova, Andrea
AU  - Polednova A
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague 14021, Czech Republic. andrea.polednova@ikem.cz.
FAU - Sukupova, Lucie
AU  - Sukupova L
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague 14021, Czech Republic. lucie.sukupova@gmail.com.
FAU - Blaha, Martin
AU  - Blaha M
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague 14021, Czech Republic. martin.blaha@ikem.cz.
FAU - Maly, Jiri
AU  - Maly J
AD  - Department of Cardiothoracic surgery, Institute for Clinical and Experimental 
      Medicine, Prague 14021, Czech Republic. jiri.maly@ikem.cz.
FAU - Honsova, Eva
AU  - Honsova E
AD  - Institute for Clinical and Experimental Medicine, Clinical and Transplant 
      Pathology Centre, Prague 14021, Czech Republic. eva.honsova@ikem.cz.
FAU - Sedmera, David
AU  - Sedmera D
AUID- ORCID: 0000-0002-6828-3671
AD  - First Faculty of Medicine, Institute of Anatomy, Charles University in Prague, 
      Prague 12800, Czech Republic. david.sedmera@lf1.cuni.cz.
FAU - Penicka, Martin
AU  - Penicka M
AD  - Cardiovascular Center Aalst, OLV Clinic, 9300, Belgium. 
      martin.penicka@olvz-aalst.be.
LA  - eng
GR  - 17-28265A/Ministerstvo Zdravotnictvi Ceske Republiky/
PT  - Journal Article
DEP - 20191011
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6832544
OTO - NOTNLM
OT  - T1 mapping
OT  - aortic regurgitation
OT  - echocardiography
OT  - longitudinal strain
OT  - magnetic resonance imaging
OT  - vena contracta area
COIS- The authors declare no conflicts of interest.
EDAT- 2019/10/17 06:00
MHDA- 2019/10/17 06:01
PMCR- 2019/10/11
CRDT- 2019/10/17 06:00
PHST- 2019/09/23 00:00 [received]
PHST- 2019/10/03 00:00 [revised]
PHST- 2019/10/06 00:00 [accepted]
PHST- 2019/10/17 06:00 [entrez]
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2019/10/17 06:01 [medline]
PHST- 2019/10/11 00:00 [pmc-release]
AID - jcm8101654 [pii]
AID - jcm-08-01654 [pii]
AID - 10.3390/jcm8101654 [doi]
PST - epublish
SO  - J Clin Med. 2019 Oct 11;8(10):1654. doi: 10.3390/jcm8101654.