PMID- 31615731
OWN - NLM
STAT- MEDLINE
DCOM- 20200520
LR  - 20200520
IS  - 1873-4030 (Electronic)
IS  - 1350-4533 (Linking)
VI  - 74
DP  - 2019 Dec
TI  - Measurement of in vitro cardiac deformation by means of 3D digital image 
      correlation and ultrasound 2D speckle-tracking echocardiography.
PG  - 146-152
LID - S1350-4533(19)30198-5 [pii]
LID - 10.1016/j.medengphy.2019.09.021 [doi]
AB  - Ultrasound-based 2D speckle-tracking echocardiography (US-2D-STE) is increasingly 
      used to assess the functionality of the heart. In particular, the analysis of 
      cardiac strain plays an important role in the identification of several 
      cardiovascular diseases. However, this imaging technique presents some 
      limitations associated with its operating principle that result in low accuracy 
      and reproducibility of the measurement. In this study, an experimental framework 
      for multimodal strain imaging in an in vitro porcine heart was developed. 
      Specifically, the aim of this work was to analyse displacement and strain in the 
      heart by means of 3D digital image correlation (3D-DIC) and US-2D-STE. Over a 
      single cardiac cycle, displacement values obtained from the two techniques were 
      in strong correlation, although systematically larger displacements were observed 
      with 3D-DIC. Notwithstanding an absolute comparison of the strain measurements 
      was not possible to achieve between the two methods, maximum principal strain 
      directions computed with 3D-DIC were consistent with the longitudinal and 
      circumferential strain distribution measured with US-2D-STE. 3D-DIC confirmed its 
      high repeatability in quantifying displacement and strain over multiple cardiac 
      cycles, unlike US-2D-STE which is affected by accumulated errors over time (i.e. 
      drift). To conclude, this study demonstrates the potential of 3D-DIC to perform 
      dynamic measurement of displacement and strain during heart deformations and 
      supports future applications of this method in ex vivo beating heart platforms, 
      which replicate more fully the complex contraction of the heart.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Ferraiuoli, Paolo
AU  - Ferraiuoli P
AD  - Mathematical Modelling in Medicine Group, Department of Infection, Immunity and 
      Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; 
      Insigneo Institute for in silico medicine, University of Sheffield, Sheffield, 
      United Kingdom. Electronic address: p.ferraiuoli@sheffield.ac.uk.
FAU - Fixsen, Louis S
AU  - Fixsen LS
AD  - Cardiovascular Biomechanics group, Department of Biomedical Engineering, 
      Eindhoven University of Technology, Eindhoven, Netherlands.
FAU - Kappler, Benjamin
AU  - Kappler B
AD  - LifeTec Group B.V., Eindhoven, Netherlands; Amsterdam University Medical Center, 
      Department Cardiothoracic Surgery, Amsterdam, Netherlands.
FAU - Lopata, Richard G P
AU  - Lopata RGP
AD  - Cardiovascular Biomechanics group, Department of Biomedical Engineering, 
      Eindhoven University of Technology, Eindhoven, Netherlands.
FAU - Fenner, John W
AU  - Fenner JW
AD  - Mathematical Modelling in Medicine Group, Department of Infection, Immunity and 
      Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; 
      Insigneo Institute for in silico medicine, University of Sheffield, Sheffield, 
      United Kingdom.
FAU - Narracott, Andrew J
AU  - Narracott AJ
AD  - Mathematical Modelling in Medicine Group, Department of Infection, Immunity and 
      Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; 
      Insigneo Institute for in silico medicine, University of Sheffield, Sheffield, 
      United Kingdom. Electronic address: a.j.narracott@sheffield.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191012
PL  - England
TA  - Med Eng Phys
JT  - Medical engineering & physics
JID - 9422753
SB  - IM
MH  - *Echocardiography
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Software
OTO - NOTNLM
OT  - 3D digital image correlation
OT  - Biomechanics
OT  - Cardiac displacement and strain
OT  - Ultrasound 2D speckle-tracking echocardiography
OT  - in vitro porcine heart
EDAT- 2019/10/17 06:00
MHDA- 2020/05/21 06:00
CRDT- 2019/10/17 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2019/07/26 00:00 [revised]
PHST- 2019/09/29 00:00 [accepted]
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2020/05/21 06:00 [medline]
PHST- 2019/10/17 06:00 [entrez]
AID - S1350-4533(19)30198-5 [pii]
AID - 10.1016/j.medengphy.2019.09.021 [doi]
PST - ppublish
SO  - Med Eng Phys. 2019 Dec;74:146-152. doi: 10.1016/j.medengphy.2019.09.021. Epub 
      2019 Oct 12.