PMID- 31616427
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20201019
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Distinct Autoimmune Anti-alpha-Synuclein Antibody Patterns in Multiple System Atrophy 
      and Parkinson's Disease.
PG  - 2253
LID - 10.3389/fimmu.2019.02253 [doi]
LID - 2253
AB  - Aggregation of alpha-synuclein (alpha-syn) is considered to be the major pathological 
      hallmark and driving force of Multiple System Atrophy (MSA) and Parkinson's 
      disease (PD). Immune dysfunctions have been associated with both MSA and PD and 
      recently we reported that the levels of natural occurring autoantibodies (NAbs) 
      with high-affinity/avidity toward alpha-synuclein are reduced in MSA and PD patients. 
      Here, we aimed to evaluate the plasma immunoglobulin (Ig) composition binding 
      alpha-syn and other amyloidogenic neuropathological proteins, and to correlate them 
      with disease severity and duration in MSA and PD patients. All participants were 
      recruited from a single neurological unit and the plasma samples were stored for 
      later research at the Bispebjerg Movement Disorder Biobank. All patients were 
      diagnosed according to current consensus criteria. Using multiple variable linear 
      regression analyses, we observed higher levels of anti-alpha-syn IgG1 and IgG3 NAbs 
      in MSA vs. PD, higher levels of anti-alpha-syn IgG2 NAbs in PD compared to controls, 
      whereas anti-alpha-syn IgG4 NAbs were reduced in PD compared to MSA and controls. 
      Anti-alpha-syn IgM levels were decreased in both MSA and PD. Further our data 
      supported that MSA patients' immune system was affected with reduced IgG1 and IgM 
      global levels compared to PD and controls, with further reduced global IgG2 
      levels compared to PD. These results suggest distinct autoimmune patterns in MSA 
      and PD. These findings suggest a specific autoimmune physiological mechanism 
      involving responses toward alpha-syn, differing in neurodegenerative disease with 
      overlapping alpha-syn pathology.
CI  - Copyright (c) 2019 Folke, Rydbirk, Lokkegaard, Salvesen, Hejl, Starhof, Bech, 
      Winge, Christensen, Pedersen, Aznar, Pakkenberg and Brudek.
FAU - Folke, Jonas
AU  - Folke J
AD  - Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg 
      Hospital, University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Rydbirk, Rasmus
AU  - Rydbirk R
AD  - Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg 
      Hospital, University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Lokkegaard, Annemette
AU  - Lokkegaard A
AD  - Department of Neurology, Bispebjerg-Frederiksberg Hospital, University Hospital 
      of Copenhagen, Copenhagen, Denmark.
FAU - Salvesen, Lisette
AU  - Salvesen L
AD  - Department of Neurology, Bispebjerg-Frederiksberg Hospital, University Hospital 
      of Copenhagen, Copenhagen, Denmark.
FAU - Hejl, Anne-Mette
AU  - Hejl AM
AD  - Department of Neurology, Bispebjerg-Frederiksberg Hospital, University Hospital 
      of Copenhagen, Copenhagen, Denmark.
FAU - Starhof, Charlotte
AU  - Starhof C
AD  - Department of Neurology, Bispebjerg-Frederiksberg Hospital, University Hospital 
      of Copenhagen, Copenhagen, Denmark.
FAU - Bech, Sara
AU  - Bech S
AD  - Department of Neurology, Bispebjerg-Frederiksberg Hospital, University Hospital 
      of Copenhagen, Copenhagen, Denmark.
FAU - Winge, Kristian
AU  - Winge K
AD  - Novo Nordisk Foundation, Hellerup, Denmark.
AD  - Bispebjerg Movement Disorders Biobank, Bispebjerg-Frederiksberg Hospital, 
      University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Christensen, Soren
AU  - Christensen S
AD  - H. Lundbeck A/S, Copenhagen, Denmark.
FAU - Pedersen, Lars Ostergaard
AU  - Pedersen LO
AD  - Department of Immunology and Microbiology, Faculty of Health, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Aznar, Susana
AU  - Aznar S
AD  - Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg 
      Hospital, University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Pakkenberg, Bente
AU  - Pakkenberg B
AD  - Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg 
      Hospital, University Hospital of Copenhagen, Copenhagen, Denmark.
AD  - Institute of Clinical Medicine, Faculty of Health, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Brudek, Tomasz
AU  - Brudek T
AD  - Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg 
      Hospital, University Hospital of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190924
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (alpha-Synuclein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/blood/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/blood/immunology
MH  - Immunoglobulin M/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/blood/diagnosis/*immunology
MH  - Parkinson Disease/blood/diagnosis/*immunology
MH  - Young Adult
MH  - alpha-Synuclein/blood/*immunology
PMC - PMC6769034
OTO - NOTNLM
OT  - alpha-synuclein
OT  - antigens
OT  - autoantibodies
OT  - autoimmunity
OT  - multiple system atrophy
OT  - neurology
OT  - parkinson's disease
OT  - plasma
EDAT- 2019/10/17 06:00
MHDA- 2020/10/21 06:00
PMCR- 2019/01/01
CRDT- 2019/10/17 06:00
PHST- 2019/03/20 00:00 [received]
PHST- 2019/09/05 00:00 [accepted]
PHST- 2019/10/17 06:00 [entrez]
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.02253 [doi]
PST - epublish
SO  - Front Immunol. 2019 Sep 24;10:2253. doi: 10.3389/fimmu.2019.02253. eCollection 
      2019.