PMID- 31617425
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 48
IP  - 2
DP  - 2020 Feb
TI  - Comparison of FRAX in postmenopausal Asian women with and without type 2 diabetes 
      mellitus: a retrospective observational study.
PG  - 300060519879591
LID - 10.1177/0300060519879591 [doi]
LID - 0300060519879591
AB  - OBJECTIVE: To compare the fracture risk in postmenopausal Asian women with or 
      without type 2 diabetes mellitus (T2DM). METHODS: The study cohort comprised data 
      from consecutive postmenopausal women with T2DM that were retrieved from a 
      prospectively maintained institutional database from 2001 to 2009. Postmenopausal 
      women without DM from the Medical Examination Center from 2001 to 2009 formed the 
      control cohort. The primary endpoint was the World Health Organization Fracture 
      Risk Algorithm (FRAX, revised 2013) score. The secondary endpoint was bone 
      mineral density (BMD). RESULTS: There were 1014 individuals included for the 
      assessment (T2DM, n=500 and non-DM, n=514). Based on the FRAX model, the risk of 
      major osteoporotic fractures and hip fractures over the next 10 years was higher 
      in the T2DM group compared with the non-DM group. Compared with the T2DM group, 
      the non-DM group had a lower BMD. After adjusting for age, gender, history of 
      alcohol consumption, smoking status, body mass index, and low-density 
      lipoprotein, the differences were statistically significant. CONCLUSIONS: 
      Compared with postmenopausal women without DM, postmenopausal women with T2DM had 
      a significantly higher fracture risk calculated using the FRAX model. Early 
      intervention for postmenopausal women with T2DM may be necessary, although T2DM 
      is associated with a high BMD.
FAU - Wang, Chen
AU  - Wang C
AUID- ORCID: 0000-0003-2322-5758
AD  - Department of Anesthesiology, Pu'ai Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 76 Jiefang Avenue, Qiaokou District, 
      Wuhan, Hubei, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Gynaecology and Obstetrics, The First Affiliated Hospital, Sun 
      Yat-sen University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, 
      China.
FAU - Xiao, Li
AU  - Xiao L
AD  - Department of Gynaecology and Obstetrics, The Central Hospital of Wuhan, Tongji 
      Medical College, Huazhong University of Science and Technology, No. 26, Shengli 
      Street, Wuhan, Hubei, China.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Internal Medicine, Amcare Primary Care & Out Patient Services 
      Center, Building 3, Anhui Beili Yiyuan, Beiyuan Road, Chaoyang District, Beijing, 
      China.
FAU - Yan, Wenjing
AU  - Yan W
AD  - Operation Room, Wuhan Central Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Gusao Shu No. 16, Jiang'an District, Wuhan, 
      China.
FAU - Hu, Ting
AU  - Hu T
AD  - Operation Room, Wuhan Central Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Gusao Shu No. 16, Jiang'an District, Wuhan, 
      China.
FAU - Li, Kunhong
AU  - Li K
AUID- ORCID: 0000-0003-0333-2150
AD  - Department of Anesthesiology, Pu'ai Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 76 Jiefang Avenue, Qiaokou District, 
      Wuhan, Hubei, China.
FAU - Hua, Xiaociao
AU  - Hua X
AD  - Department of Anesthesiology, The Guanghua School of Stomatology, Hospital of 
      Stomatology, Sun Yat-sen University, No. 56, Lingyuan West Road, Guangzhou, 
      China.
FAU - Zeng, Xianshang
AU  - Zeng X
AD  - Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen 
      University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20191016
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Aged
MH  - Bone Density
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Osteoporosis, Postmenopausal/complications
MH  - *Osteoporotic Fractures/epidemiology
MH  - Postmenopause
MH  - Risk Assessment
MH  - *Risk Factors
PMC - PMC7783259
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - FRAX
OT  - bone mineral density
OT  - fracture risk assessment tool
OT  - hip fracture
OT  - osteoporosis
OT  - osteoporotic fracture
OT  - postmenopausal
EDAT- 2019/10/17 06:00
MHDA- 2021/04/27 06:00
PMCR- 2019/10/16
CRDT- 2019/10/17 06:00
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2019/10/17 06:00 [entrez]
PHST- 2019/10/16 00:00 [pmc-release]
AID - 10.1177_0300060519879591 [pii]
AID - 10.1177/0300060519879591 [doi]
PST - ppublish
SO  - J Int Med Res. 2020 Feb;48(2):300060519879591. doi: 10.1177/0300060519879591. 
      Epub 2019 Oct 16.