PMID- 31617647
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210301
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 25
IP  - 2
DP  - 2020 Mar
TI  - Characterization of cardiac acoustic biomarkers in patients with heart failure.
PG  - e12717
LID - 10.1111/anec.12717 [doi]
LID - e12717
AB  - BACKGROUND: The wearable cardioverter defibrillator (WCD) records 
      electrocardiograms and cardiohemic vibrations that can be algorithmically 
      combined to provide cardiac acoustic biomarkers (CABs). We characterized CAB 
      variability, diurnal variations, and changes over time among heart failure 
      patients. METHODS: Wearable cardioverter defibrillator heart failure patients who 
      had CAB recordings from March 2015 to July 2017 were included. CAB parameters 
      included: electromechanical activation time (EMAT), EMATc (EMAT/RR interval), 
      left ventricular systolic time (LVST), LVSTc (LVST/RR interval), S3 and S4 
      strengths, and systolic dysfunction index (SDI). Descriptive statistics, 
      correlation analysis, and analysis of variance were used to report temporal and 
      clinical associations. RESULTS: One thousand and sixty-six WCD patients met the 
      study criteria. Diastolic CAB parameters showed significantly greater 
      intra-subject variability than systolic CAB parameters (>29% vs. <15%, p < .01). 
      CAB parameters varied very little with age, gender, and ejection fraction (R(2) 
       = 0.004 to 0.06) in this heart failure population. Similarly, all CABs except 
      SDI (R(2)  = 0.58) were independent of QRS duration, (R(2 ) = -0.01 to 0.58). 
      Heart rate had a more of significant influence on the systolic CABs than the 
      diastolic CABs (p < .05). CABs were significantly different when measured at 
      daytime versus nighttime (p < .01) and were significantly lower at the end of WCD 
      wear compared with the beginning of wear (p < .05). CONCLUSIONS: Noninvasive CABs 
      offer the possibility to assess parameters associated with LV function, clinical 
      status, and other aspects of cardiovascular physiology that differ between normal 
      and heart failure states. The present study provides critical information about 
      typical values in heart failure patients, intra-subject variability, circadian 
      rhythms, and changes over time of these parameters.
CI  - (c) 2019 The Authors. Annals of Noninvasive Electrocardiology published by Wiley 
      Periodicals, Inc.
FAU - Burkhoff, Daniel
AU  - Burkhoff D
AUID- ORCID: 0000-0003-3995-2466
AD  - Cardiovascular Research Foundation, New York City, New York.
FAU - Bailey, Grant
AU  - Bailey G
AD  - South Denver Cardiology Associates, P.C., Denver, Colorado.
FAU - Gimbel, J Rod
AU  - Gimbel JR
AD  - Independent consultant, Milwaukee, Wisconsin.
LA  - eng
PT  - Journal Article
DEP - 20191016
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Acoustics
MH  - Biomarkers/*analysis
MH  - Circadian Rhythm
MH  - Electric Countershock/*instrumentation
MH  - Electrocardiography/*instrumentation
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Wearable Electronic Devices
PMC - PMC7358835
OTO - NOTNLM
OT  - heart failure
OT  - systolic time interval
OT  - wearable cardiac defibrillator
COIS- DB is a consultant to Zoll Medical.
EDAT- 2019/10/17 06:00
MHDA- 2021/03/02 06:00
PMCR- 2019/10/16
CRDT- 2019/10/17 06:00
PHST- 2019/07/30 00:00 [received]
PHST- 2019/09/10 00:00 [revised]
PHST- 2019/09/17 00:00 [accepted]
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2019/10/17 06:00 [entrez]
PHST- 2019/10/16 00:00 [pmc-release]
AID - ANEC12717 [pii]
AID - 10.1111/anec.12717 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2020 Mar;25(2):e12717. doi: 10.1111/anec.12717. 
      Epub 2019 Oct 16.