PMID- 31618228
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20200316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 10
DP  - 2019
TI  - Outcomes of acute coronary syndrome patients with concurrent extra-cardiac 
      vascular disease in the era of transradial coronary intervention: A retrospective 
      multicenter cohort study.
PG  - e0223215
LID - 10.1371/journal.pone.0223215 [doi]
LID - e0223215
AB  - BACKGROUND: Extra-cardiac vascular diseases (ECVDs), such as cerebrovascular 
      disease (CVD) or peripheral arterial disease (PAD), are frequently observed among 
      patients with acute coronary syndrome (ACS). However, it is not clear how these 
      conditions affect patient outcomes in the era of transradial coronary 
      intervention (TRI). METHODS AND RESULTS: Among 7,980 patients with ACS whose data 
      were extracted from the multicenter Japanese percutaneous coronary intervention 
      (PCI) registry between August 2008 and March 2017, 888 (11.1%) had one concurrent 
      ECVD (either PAD [345 patients: 4.3%] or CVD [543 patients; 6.8%]), while 87 
      patients (1.1%) had both PAD and CVD. Overall, the presence of ECVD was 
      associated with a higher risk of mortality (odds ratio [OR]: 1.728; 95% 
      confidence interval [CI]: 1.183-2.524) and bleeding complications (OR: 1.430; 95% 
      CI: 1.028-2.004). There was evidence of interaction between ECVD severity and 
      procedural access site on bleeding complication on the additive scale (relative 
      excess risk due to interaction: 0.669, 95% CI: -0.563-1.900) and on the 
      multiplicative scale (OR: 2.105; 95% CI: 1.075-4.122). While the incidence of 
      death among patients with ECVD remained constant during the study period, 
      bleeding complications among patients with ECVD rapidly decreased from 2015 to 
      2017, in association with the increasing number of TRI. CONCLUSIONS: Overall, the 
      presence of ECVD was a risk factor for adverse outcomes after PCI for ACS, both 
      mortality and bleeding complications. In the most recent years, the incidence of 
      bleeding complications among patients with ECVD decreased significantly 
      coinciding with the rapid increase of TRI.
FAU - Kodaira, Masaki
AU  - Kodaira M
AUID- ORCID: 0000-0002-7293-617X
AD  - Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan.
FAU - Sawano, Mitsuaki
AU  - Sawano M
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Kuno, Toshiki
AU  - Kuno T
AD  - Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan.
AD  - Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth 
      Israel, New York, New York, United States of America.
FAU - Numasawa, Yohei
AU  - Numasawa Y
AD  - Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan.
FAU - Noma, Shigetaka
AU  - Noma S
AD  - Department of Cardiology, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
FAU - Suzuki, Masahiro
AU  - Suzuki M
AD  - Department of Cardiology, National Hospital Organization Saitama Hospital, 
      Saitama, Japan.
FAU - Imaeda, Shohei
AU  - Imaeda S
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Ueda, Ikuko
AU  - Ueda I
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Fukuda, Keiichi
AU  - Fukuda K
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
FAU - Kohsaka, Shun
AU  - Kohsaka S
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191016
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acute Coronary Syndrome/complications/*surgery
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebrovascular Disorders/*complications/diagnosis
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Peripheral Vascular Diseases/*complications/diagnosis
MH  - Postoperative Hemorrhage/*epidemiology/etiology
MH  - Radial Artery/surgery
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Treatment Outcome
PMC - PMC6795465
COIS- Dr. Kohsaka has received grants from Bayer Yakuhin and Daiichi-Sankyo; has 
      received lecture fees from Bayer Y.akuhin and Bristol-Myers Squibb. This does not 
      alter our adherence to PLOS ONE policies on sharing data and materials.
EDAT- 2019/10/17 06:00
MHDA- 2020/03/17 06:00
PMCR- 2019/10/16
CRDT- 2019/10/17 06:00
PHST- 2019/06/17 00:00 [received]
PHST- 2019/09/16 00:00 [accepted]
PHST- 2019/10/17 06:00 [entrez]
PHST- 2019/10/17 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2019/10/16 00:00 [pmc-release]
AID - PONE-D-19-17185 [pii]
AID - 10.1371/journal.pone.0223215 [doi]
PST - epublish
SO  - PLoS One. 2019 Oct 16;14(10):e0223215. doi: 10.1371/journal.pone.0223215. 
      eCollection 2019.