PMID- 31619295
OWN - NLM
STAT- MEDLINE
DCOM- 20200115
LR  - 20231104
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 15
IP  - 1
DP  - 2019 Oct 16
TI  - Evaluation of the efficacy of a trivalent vaccine mixture against a triple 
      challenge with Mycoplasma hyopneumoniae, PCV2, and PRRSV and the efficacy 
      comparison of the respective monovalent vaccines against a single challenge.
PG  - 342
LID - 10.1186/s12917-019-2091-6 [doi]
LID - 342
AB  - BACKGROUND: The objective of this study was to assess the efficacy of a trivalent 
      vaccine mixture and compare it to the respective monovalent vaccines against 
      Mycoplasma hyopneumoniae, porcine circovirus type 2 (PCV2), and porcine 
      reproductive and respiratory syndrome virus (PRRSV). RESULTS: Pigs that were 
      triple challenged with M. hyopneumoniae, PCV2, and PRRSV following vaccination 
      with the trivalent vaccine mixture exhibited a significantly better growth 
      performance when compared to unvaccinated and challenged pigs. A statistical 
      difference was not found when comparing pig populations which were vaccinated 
      with the trivalent vaccine followed by a triple challenge and pigs vaccinated 
      with monovalent M hyopneumoniae vaccine followed by mycoplasmal single challenge 
      in the following areas: M. hyopneumoniae nasal shedding, the number of M. 
      hyopneumoniae-specific interferon-gamma secreting cells (IFN-gamma-SC), and mycoplasmal 
      lung lesion scores. Pigs vaccinated with the trivalent vaccine mixture followed 
      by a triple challenge resulted in a similar reduction of PCV2 viremia, an 
      increase in the number of PCV2-specific IFN-gamma-SC and reduction in interstitial 
      lung lesion scores when compared to pigs vaccinated with a PCV-2 vaccine and 
      challenged with PCV2 only. Lastly, there was a significant difference in the 
      reduction of PRRSV viremia, an increase in PRRSV-specific IFN-gamma-SC and a 
      reduction of interstitial lung lesion scores between pigs vaccinated with the 
      trivalent vaccine mixture followed by a triple challenge and pigs vaccinated with 
      a monovalent PRRSV vaccine followed by PRRSV challenge only. CONCLUSION: The 
      trivalent vaccine mixture was efficacious against a triple challenge of M. 
      hyopneumoniae, PCV2, and PRRSV. The trivalent vaccine mixture, however, did not 
      result in equal protection when compared against each respective monovalent 
      vaccine, with the largest vaccine occurring within PRRSV.
FAU - Oh, Taehwan
AU  - Oh T
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AUID- ORCID: 0000-0002-0190-1957
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea. 
      swine@snu.ac.kr.
LA  - eng
GR  - 550-20170104/Research Institute for Veterinary Science/
GR  - 5260-20150100/BK 21 Plus Program for Creative Veterinary Science Research/
PT  - Journal Article
DEP - 20191016
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Vaccines, Combined)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Vaccines/immunology
MH  - Circoviridae Infections/immunology/prevention & control
MH  - Circovirus/*immunology
MH  - Female
MH  - Male
MH  - Mycoplasma hyopneumoniae/*immunology
MH  - Pneumonia of Swine, Mycoplasmal/immunology/prevention & control
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Sus scrofa
MH  - Swine
MH  - Swine Diseases/immunology/microbiology/*prevention & control/virology
MH  - Vaccination/*veterinary
MH  - Vaccines, Combined/administration & dosage/immunology
MH  - Viral Vaccines/immunology
PMC - PMC6794872
OTO - NOTNLM
OT  - Mycoplasma hyopneumoniae
OT  - Porcine circovirus type 2
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine respiratory disease complex
COIS- The authors declare that they have no competing interests.
EDAT- 2019/10/18 06:00
MHDA- 2020/01/16 06:00
PMCR- 2019/10/16
CRDT- 2019/10/18 06:00
PHST- 2018/05/26 00:00 [received]
PHST- 2019/09/16 00:00 [accepted]
PHST- 2019/10/18 06:00 [entrez]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/01/16 06:00 [medline]
PHST- 2019/10/16 00:00 [pmc-release]
AID - 10.1186/s12917-019-2091-6 [pii]
AID - 2091 [pii]
AID - 10.1186/s12917-019-2091-6 [doi]
PST - epublish
SO  - BMC Vet Res. 2019 Oct 16;15(1):342. doi: 10.1186/s12917-019-2091-6.