PMID- 31620350
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2229-5151 (Print)
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 9
IP  - 3
DP  - 2019 Jul-Sep
TI  - Metabolic profile and prolactin serum levels in men with type 2 diabetes 
      mellitus: Old-new rubric.
PG  - 120-126
LID - 10.4103/IJCIIS.IJCIIS_40_19 [doi]
AB  - BACKGROUND: Prolactin (PRL) is involved in the regulation of glucose metabolism 
      since high PRL serum levels are associated with low incidence of type 2 diabetes 
      mellitus (T2DM). Therefore, the aim of the present study was to assess the 
      metabolic effects of PRL on glucose homeostasis in men with T2DM. METHODS: Eighty 
      male patients with T2DM compared with 25 male healthy controls matched with 
      patients for age and weight were divided into four groups: Group (A): patients 
      with T2DM on metformin (n = 29), Group (B): patients with T2DM on glyburide (n = 
      30), Group (C): patients with T2DM on glyburide plus metformin (n = 21), and 
      Group (D): healthy male subjects as control (n = 25). Body mass index (BMI) and 
      blood pressure measurements were determined. Fasting blood glucose (FBG), 
      glycated hemoglobin, total cholesterol, triglyceride (TG), high-density 
      lipoprotein, low-density lipoprotein, atherogenic index, fasting serum insulin, 
      insulin resistance (IR), and beta-cell function of the pancreas were determined by 
      homeostatic model assessment-2 (HOMA-IR). Furthermore, C-reactive protein and PRL 
      serum level were determined in patients with T2DM and healthy control men. 
      RESULTS: BMI of T2DM patients was higher as compared with control (P = 0.003). 
      Combination therapy (glyburide plus metformin) in patients with T2DM showed 
      better effect on most of glycemic indices and lipid profile than glyburide or 
      metformin monotherapy (P < 0.05). PRL serum level was higher in patients with 
      T2DM as compared with control (P = 0.001). PRL serum level was high in 
      glyburide-treated patients as compared with metformin-treated patients (P = 
      0.002). CONCLUSION: This study concludes that elevated PRL serum level in 
      patients with T2DM is associated with diabetic complications. Diabetic 
      pharmacotherapy mainly metformin reduced PRL serum level in patients with T2DM 
      through amelioration of IR.
CI  - Copyright: (c) 2019 International Journal of Critical Illness and Injury Science.
FAU - Al-Nami, Marwa S
AU  - Al-Nami MS
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Al-Mustansiriya University, Baghdad, Iraq.
FAU - Al-Kuraishy, Hayder M
AU  - Al-Kuraishy HM
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Al-Mustansiriya University, Baghdad, Iraq.
FAU - Al-Gareeb, Ali I
AU  - Al-Gareeb AI
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Al-Mustansiriya University, Baghdad, Iraq.
FAU - Al-Mamoori, Farah
AU  - Al-Mamoori F
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, 
      Amman, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20190930
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC6792395
OTO - NOTNLM
OT  - Glyburide
OT  - metformin
OT  - prolactin
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2019/10/18 06:00
MHDA- 2019/10/18 06:01
PMCR- 2019/07/01
CRDT- 2019/10/18 06:00
PHST- 2019/05/03 00:00 [received]
PHST- 2019/07/23 00:00 [revised]
PHST- 2019/08/06 00:00 [accepted]
PHST- 2019/10/18 06:00 [entrez]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2019/10/18 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - IJCIIS-9-120 [pii]
AID - 10.4103/IJCIIS.IJCIIS_40_19 [doi]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2019 Jul-Sep;9(3):120-126. doi: 
      10.4103/IJCIIS.IJCIIS_40_19. Epub 2019 Sep 30.