PMID- 31620574
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2384-0293 (Print)
IS  - 2384-0293 (Electronic)
IS  - 2384-0293 (Linking)
VI  - 35
IP  - 1
DP  - 2018 Jun
TI  - Chemotherapy adherence is a favorable prognostic factor for elderly patients with 
      multiple myeloma who are treated with a frontline bortezomib-containing regimen.
PG  - 76-83
LID - 10.12701/yujm.2018.35.1.76 [doi]
AB  - BACKGROUND: Elderly patients with multiple myeloma (MM) are vulnerable to adverse 
      events (AEs). This study evaluated adherence to chemotherapy and treatment 
      outcomes in elderly patients treated with a frontline bortezomib (BTZ), 
      melphalan, and prednisone (VMP) regimen and regimens without BTZ. METHODS: 
      One-hundred and forty elderly patients who were diagnosed with MM from March 2007 
      to March 2015 were included in this retrospective study. To evaluate regimen 
      adherence, patients who were treated with more than 4 cycles were assigned to the 
      good adherence group. RESULTS: Among the 140 patients, 71 were treated with a 
      frontline VMP and 69 with non-BTZ regimens. The median age was 71 years (range, 
      65-90 years). The VMP group showed a higher complete response rate than the 
      non-BTZ group: 26.8% vs. 7.2%. More patients in the VMP group achieved >/=very good 
      partial response (VGPR) and >/=PR. In the VMP group, 27 patients (38.0%) received 
      less than 4 cycles. The VMP good adherence group showed a higher 3-year overall 
      survival (OS) rate (70.9%) than the poor adherence group (60.2%, p=0.059). In the 
      multivariate analysis, treatment with >/=4 cycles of VMP was a favorable factor for 
      OS. CONCLUSION: A good adherence to a frontline VMP regimen resulted in favorable 
      long-term survival. Adequate management of AEs will be needed to achieve 
      favorable outcomes in elderly patients with MM.
CI  - Copyright (c) 2018 Yeungnam University College of Medicine.
FAU - Cho, Hee-Jeong
AU  - Cho HJ
AUID- ORCID: 0000-0001-8300-8179
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Seo, Sang-Kyung
AU  - Seo SK
AUID- ORCID: 0000-0001-5677-7394
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Baek, Dong Won
AU  - Baek DW
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Park, Sung-Woo
AU  - Park SW
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Lee, Yoo-Jin
AU  - Lee YJ
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Sohn, Sang-Kyun
AU  - Sohn SK
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
FAU - Lee, Ho-Sup
AU  - Lee HS
AD  - Department of Hematology/Oncology, Kosin University Gospel Hospital, Busan, 
      Korea.
FAU - Lee, Won Sik
AU  - Lee WS
AD  - Department of Hematology-Oncology, Inje University Pusan Baik Hospital, Busan, 
      Korea.
FAU - Lee, Ji Hyun
AU  - Lee JH
AD  - Department of Hematology-Oncology, Dong-A University Hospital, Busan, Korea.
FAU - Kim, Sung Hyun
AU  - Kim SH
AD  - Department of Hematology-Oncology, Dong-A University Hospital, Busan, Korea.
FAU - Moon, Joon-Ho
AU  - Moon JH
AUID- ORCID: 0000-0003-3756-796X
AD  - Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20180630
PL  - Korea (South)
TA  - Yeungnam Univ J Med
JT  - Yeungnam University journal of medicine
JID - 101590467
PMC - PMC6784679
OTO - NOTNLM
OT  - Bortezomib
OT  - Elderly
OT  - Medication adherence
OT  - Multiple myeloma
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/06/30 00:00
MHDA- 2018/06/30 00:01
PMCR- 2018/06/30
CRDT- 2019/10/18 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/06/08 00:00 [revised]
PHST- 2018/06/08 00:00 [accepted]
PHST- 2019/10/18 06:00 [entrez]
PHST- 2018/06/30 00:00 [pubmed]
PHST- 2018/06/30 00:01 [medline]
PHST- 2018/06/30 00:00 [pmc-release]
AID - yujm-2018-35-1-76 [pii]
AID - 10.12701/yujm.2018.35.1.76 [doi]
PST - ppublish
SO  - Yeungnam Univ J Med. 2018 Jun;35(1):76-83. doi: 10.12701/yujm.2018.35.1.76. Epub 
      2018 Jun 30.