PMID- 31621036
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20210819
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 32
IP  - 9
DP  - 2020 Sep
TI  - Differential characteristics of acute heart failure in very elderly patients: the 
      prospective RICA study.
PG  - 1789-1799
LID - 10.1007/s40520-019-01363-8 [doi]
AB  - INTRODUCTION: Acute heart failure (AHF) is a frequent epidemic in geriatrics. The 
      main aim of this study was to evaluate the clinical and prognostic differences of 
      very elderly patients with AHF compared to the rest, and evaluate the factors 
      associated with 90-day mortality. METHODS: We analyzed 3828 patients hospitalized 
      for AHF with an age of >/= 70 years. The population was divided into three groups: 
      70-79, 80-89 and >/= 90 years old (nonagenarians). The baseline characteristics of 
      patients nonagenarians were compared with the rest. In the group of 
      nonagenarians, their clinical characteristics were analyzed according to the left 
      ventricular ejection fraction (LVEF) and the factors associated with mortality at 
      90 days of follow-up. RESULTS: Nonagenarians showed higher comorbidity and 
      cognitive deterioration, worse basal functional status, and preserved LVEF. 
      Alternatively, they presented a lower rate of diabetes mellitus, lower incidence 
      of de novo AHF, and lower prescription of angiotensin-converting-enzyme 
      inhibitors, aldosterone blockers, anticoagulants, and statins at hospital 
      discharge. Of the total, 334 patients (9.3%) had died by 90 days. The 90-day 
      mortality rate was highest in nonagenarians (7.1% vs 9.8% vs 17%; p = 0.001). 
      Multivariate analysis showed that renal failure, New York Heart Association 
      (NYHA) functional classifications of III-IV, and a more advanced functional 
      deterioration at baseline are predictors of mortality within 90 days. 
      CONCLUSIONS: The AHF in patients nonagenarians has a different clinical profile 
      compared to younger patients and a higher mortality. In this subgroup of patients 
      having a worse baseline functional status, higher NYHA classification (III-IV), 
      and renal failure are predictors of 90-day mortality.
FAU - Huerta-Preciado, Jorge
AU  - Huerta-Preciado J
AUID- ORCID: 0000-0002-4313-5277
AD  - Department of Internal Medicine, Hospital Universitario Quiron Dexeus, Barcelona, 
      Spain. huertap@gmail.com.
FAU - Franco, Jonathan
AU  - Franco J
AD  - Department of Internal Medicine, Hospital Universitario Quiron Dexeus, Barcelona, 
      Spain.
FAU - Formiga, Francesc
AU  - Formiga F
AD  - Department of Internal Medicine, Hospital Universitario Bellvitge, Hospitalet de 
      Llobregat, Barcelona, Spain.
FAU - Iborra, Pau Llacer
AU  - Iborra PL
AD  - Department of Internal Medicine, Hospital de Manises, Manises, Spain.
FAU - Epelde, Francisco
AU  - Epelde F
AD  - Short-Stay Unit, Hospital Universitari Parc Tauli, Sabadell, Spain.
FAU - Franco, Alvaro Gonzalez
AU  - Franco AG
AD  - Department of Internal Medicine, Hospital Universitario Central de Asturias, 
      Oviedo, Spain.
FAU - Ormaechea, Gabriela
AU  - Ormaechea G
AD  - Multidisciplinary Unit on Heart Failure, Hospital de Clinicas Dr. Manuel 
      Quintela, Montevideo, Uruguay.
FAU - Manzano, Luis
AU  - Manzano L
AD  - Department of Internal Medicine, Hospital Universitario Ramon y Cajal, 
      Universidad de Alcala/IRYCIS, Madrid, Spain.
FAU - Cepeda-Rodrigo, Jose Maria
AU  - Cepeda-Rodrigo JM
AD  - Department of Internal Medicine, Hospital Vega Baja, Orihuela, Spain.
FAU - Montero-Perez-Barquero, Manuel
AU  - Montero-Perez-Barquero M
AD  - Department of Internal Medicine, IMIBIC/Hospital Universitario Reina Sofia, 
      Universidad de Cordoba, Cordoba, Spain.
CN  - With the Aid of RICA Investigators Group
LA  - eng
PT  - Journal Article
DEP - 20191016
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Comorbidity
MH  - *Heart Failure/epidemiology
MH  - Humans
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Comorbidities
OT  - Heart failure
OT  - Intermediate ejection fraction
OT  - Nonagenarians
OT  - Prognosis
FIR - Alvarez Rocha, P
IR  - Alvarez Rocha P
FIR - Anarte, L
IR  - Anarte L
FIR - Arevalo-Lorido, J C
IR  - Arevalo-Lorido JC
FIR - Cabanes, Y
IR  - Cabanes Y
FIR - Carrascosa, S
IR  - Carrascosa S
FIR - Carrera Izquierdo, M
IR  - Carrera Izquierdo M
FIR - Cepeda, J M
IR  - Cepeda JM
FIR - Cerqueiro, J M
IR  - Cerqueiro JM
FIR - Conde Martel, A
IR  - Conde Martel A
FIR - Epelde, F
IR  - Epelde F
FIR - Formiga, F
IR  - Formiga F
FIR - Franco Vanegas, J
IR  - Franco Vanegas J
FIR - Garcia Escriva, D
IR  - Garcia Escriva D
FIR - Gonzalez Franco, A
IR  - Gonzalez Franco A
FIR - Leon, A
IR  - Leon A
FIR - Llacer, P
IR  - Llacer P
FIR - Lopez-Castellanos, G
IR  - Lopez-Castellanos G
FIR - Lorente Furio, O
IR  - Lorente Furio O
FIR - Manzano, L
IR  - Manzano L
FIR - Montero-Perez-Barquero, M
IR  - Montero-Perez-Barquero M
FIR - Ormaechea, G
IR  - Ormaechea G
FIR - Perez-Silvestre, J
IR  - Perez-Silvestre J
FIR - Ruiz Ortega, R
IR  - Ruiz Ortega R
FIR - Suarez-Pedreira, I
IR  - Suarez-Pedreira I
EDAT- 2019/10/18 06:00
MHDA- 2020/12/01 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/06/09 00:00 [received]
PHST- 2019/09/21 00:00 [accepted]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - 10.1007/s40520-019-01363-8 [pii]
AID - 10.1007/s40520-019-01363-8 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2020 Sep;32(9):1789-1799. doi: 10.1007/s40520-019-01363-8. 
      Epub 2019 Oct 16.