PMID- 31621498
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20201214
IS  - 2578-5478 (Electronic)
IS  - 2578-5478 (Linking)
VI  - 38
IP  - 2
DP  - 2020 Feb
TI  - Increased Functional Connectivity Within Intrinsic Neural Networks in Chronic 
      Stroke Following Treatment with Red/Near-Infrared Transcranial 
      Photobiomodulation: Case Series with Improved Naming in Aphasia.
PG  - 115-131
LID - 10.1089/photob.2019.4630 [doi]
AB  - Objective: To examine effects of four different transcranial, red/near-infrared 
      (NIR), light-emitting diode (tLED) protocols on naming ability in persons with 
      aphasia (PWA) due to left hemisphere (LH) stroke. This is the first study to 
      report beneficial effects from tLED therapy in chronic stroke, and parallel 
      changes on functional magnetic resonance imaging (fMRI). Materials and methods: 
      Six PWA, 2-18 years poststroke, in whom 18 tLED treatments were applied 
      (3 x /week, 6 weeks) using LED cluster heads: 500 mW, red (633 nm) and NIR 
      (870 nm), 22.48 cm(2), 22.2 mW/cm(2). Results: After Protocol A with bilateral 
      LED placements, including midline, at scalp vertex over left and right 
      supplementary motor areas (L and R SMAs), picture naming was not improved. P1 
      underwent pre-/postovert, picture-naming task-fMRI scans; P2 could not. After 
      Protocol A, P1 showed increased activation in LH and right hemisphere, including 
      L and R SMAs. After Protocol B with LEDs only on ipsilesional, LH side, naming 
      ability significantly improved for P1 and P2; the fMRI scans for P1 then showed 
      activation only on the ipsilesional LH side. After Protocol C with LED placements 
      on ipsilesional LH side, plus one midline placement over mesial prefrontal cortex 
      (mPFC) at front hairline, a cortical node of the default mode network (DMN), P3 
      and P4 had only moderate/poor response, and no increase in functional 
      connectivity on resting-state functional-connectivity MRI. After Protocol D, 
      however, with LED placements on ipsilesional LH side, plus over two midline nodes 
      of DMN, mPFC, and precuneus (high parietal) simultaneously, P5 and P6 each had 
      good response with significant increase in functional connectivity within DMN, 
      p < 0.0005; salience network, p < 0.0005; and central executive network, 
      p < 0.05. Conclusions: NIR photons can affect surface brain cortex areas 
      subjacent to where LEDs are applied on the scalp. Improved naming ability was 
      present with optimal Protocol D. Transcranial photobiomodulation may be an 
      additional noninvasive therapy for stroke.
FAU - Naeser, Margaret A
AU  - Naeser MA
AD  - VA Boston Healthcare System (12-A), Boston, Massachusetts.
AD  - Department of Neurology, Boston University School of Medicine, Boston, 
      Massachusetts.
FAU - Ho, Michael D
AU  - Ho MD
AD  - VA Boston Healthcare System (12-A), Boston, Massachusetts.
FAU - Martin, Paula I
AU  - Martin PI
AD  - VA Boston Healthcare System (12-A), Boston, Massachusetts.
AD  - Department of Neurology, Boston University School of Medicine, Boston, 
      Massachusetts.
FAU - Hamblin, Michael R
AU  - Hamblin MR
AD  - Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 
      Massachusetts.
AD  - Department of Dermatology, Harvard Medical School, Boston, Massachusetts.
AD  - Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts.
FAU - Koo, Bang-Bon
AU  - Koo BB
AD  - Brain-Imaging and Informatics Lab (BIL), Department of Anatomy and Neurobiology, 
      Boston University School of Medicine, Boston, Massachusetts.
LA  - eng
PT  - Journal Article
DEP - 20191017
PL  - United States
TA  - Photobiomodul Photomed Laser Surg
JT  - Photobiomodulation, photomedicine, and laser surgery
JID - 101734781
SB  - IM
MH  - Aged
MH  - Aphasia/diagnostic imaging/*physiopathology
MH  - Brain Damage, Chronic/diagnostic imaging/physiopathology/*radiotherapy
MH  - *Connectome
MH  - Humans
MH  - Low-Level Light Therapy/*methods
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Stroke/diagnostic imaging/physiopathology/*radiotherapy
MH  - *Verbal Behavior
OTO - NOTNLM
OT  - PBM
OT  - aphasia treatment
OT  - default mode network
OT  - fMRI
OT  - functional connectivity
OT  - stroke
EDAT- 2019/10/18 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - 10.1089/photob.2019.4630 [doi]
PST - ppublish
SO  - Photobiomodul Photomed Laser Surg. 2020 Feb;38(2):115-131. doi: 
      10.1089/photob.2019.4630. Epub 2019 Oct 17.