PMID- 31621657
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20240328
IS  - 1117-1936 (Print)
VI  - 26
IP  - 4
DP  - 2019 Oct-Dec
TI  - Absence of human leukocyte antigen-B*57:01 amongst patients on antiretroviral 
      therapy in Nigeria: Implications for use of abacavir.
PG  - 195-198
LID - 10.4103/npmj.npmj_75_19 [doi]
AB  - BACKGROUND: The presence of human leukocyte antigen (HLA) B*57:01 allele predicts 
      hypersensitivity reaction (HSR) to abacavir (ABC), a nucleoside 
      reverse-transcriptase inhibitor used for human immunodeficiency virus (HIV) 
      treatment. However, the prevalence of this allele amongst Nigerians with HIV is 
      yet to be established. We aimed to determine the prevalence of HLA-B*57:01 allele 
      amongst Nigerians with HIV infection. METHODS: We conducted a multicentre 
      cross-sectional epidemiologic survey. Between April 2016 and April 2017, patients 
      were enrolled across five HIV treatment facilities in Nigeria. Participants' 
      demographic information and their history of ABC exposure were obtained, and 
      venous blood was obtained for HLA typing. RESULTS: One thousand five hundred and 
      four (1504) adults were enrolled, with a mean age of 44.6 +/- 10.7 years, 1078 
      (71.7%) were female. 1463 (97.3%) were on antiretroviral therapy. ABC use was 
      reported by 12 (0.8%) participants and none reported HSR. Of 1500 blood samples 
      that were processed, 1458 (97.2%) were successfully typed. Of these, 132 (9.1%) 
      were HLA-B*57 positive using non-specific low-resolution HLA-B*5701 primer mix. 
      On further analysis, none of the 132 samples (0%) had the HLA-B*5701 allele. 
      CONCLUSION: HLA-B*5701allele is rare amongst Nigerians.
FAU - Agbaji, Oche O
AU  - Agbaji OO
AD  - Department of Medicine, University of Jos/Jos University Teaching Hospital; 
      Department of AIDS Prevention Initiative in Nigeria (APIN)-Supported HIV 
      Treatment Centre, Jos University Teaching Hospital, Jos, Nigeria.
FAU - Akanbi, Maxwell O
AU  - Akanbi MO
AD  - Department of Medicine, University of Jos/Jos University Teaching Hospital; 
      Department of AIDS Prevention Initiative in Nigeria (APIN)-Supported HIV 
      Treatment Centre, Jos University Teaching Hospital, Jos, Nigeria; Health Sciences 
      Integrated PhD Program, Center for Education in Health Sciences, Feinberg School 
      of Medicine, Northwestern University, Chicago, Illinois, USA.
FAU - Otoh, Ihedinachi
AU  - Otoh I
AD  - Department of AIDS Prevention Initiative in Nigeria (APIN)-Supported HIV 
      Treatment Centre, Jos University Teaching Hospital, Jos, Nigeria.
FAU - Agaba, Patricia A
AU  - Agaba PA
AD  - Department of AIDS Prevention Initiative in Nigeria (APIN)-Supported HIV 
      Treatment Centre, Jos University Teaching Hospital; Department of Family 
      Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
FAU - Akinsola, Rolake
AU  - Akinsola R
AD  - Department of Molecular Biology Research Laboratory, Lagos University Teaching 
      Hospital, Lagos, Nigeria.
FAU - Okolie, Victoria
AU  - Okolie V
AD  - Department of Molecular Biology Research Laboratory, Lagos University Teaching 
      Hospital, Lagos, Nigeria.
FAU - Ugoagwu, Placid O
AU  - Ugoagwu PO
AD  - Department of AIDS Prevention Initiative in Nigeria (APIN)-Supported HIV 
      Treatment Centre, Jos University Teaching Hospital, Jos, Nigeria.
FAU - Babadoko, Aliyu A
AU  - Babadoko AA
AD  - Department of Hematology, Ahmadu Bello University/Ahmadu Bello University 
      Teaching Hospital, Zaria, Nigeria.
FAU - Adediran, Adewumi
AU  - Adediran A
AD  - Department of Hematology, College of Medicine, University of Lagos/Lagos 
      University Teaching Hospital, Lagos, Nigeria.
FAU - Finomo, Finomo O
AU  - Finomo FO
AD  - Department of Medicine, Federal Medical Centre, Yenagoa, Nigeria.
FAU - Abah, Jonah O
AU  - Abah JO
AD  - Department of Family Medicine, Federal Medical Centre, Makurdi, Nigeria.
FAU - Muktar, Haruna M
AU  - Muktar HM
AD  - Department of Hematology, Ahmadu Bello University/Ahmadu Bello University 
      Teaching Hospital, Zaria, Nigeria.
FAU - Akanmu, Alani S
AU  - Akanmu AS
AD  - Department of Hematology, College of Medicine, University of Lagos/Lagos 
      University Teaching Hospital, Lagos, Nigeria.
LA  - eng
GR  - D43 TW009575/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Nigeria
TA  - Niger Postgrad Med J
JT  - The Nigerian postgraduate medical journal
JID - 9613595
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/*therapeutic use
MH  - Black People/genetics
MH  - Cross-Sectional Studies
MH  - Dideoxynucleosides/adverse effects/*therapeutic use
MH  - Drug Hypersensitivity/epidemiology/genetics/*immunology
MH  - Female
MH  - HIV Infections/*drug therapy/epidemiology/genetics/*immunology
MH  - HLA-B Antigens/blood/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Reverse Transcriptase Inhibitors/adverse effects/*therapeutic use
PMC - PMC7024598
MID - NIHMS1554904
OTO - NOTNLM
OT  - Abacavir
OT  - Africa
OT  - antiretroviral therapy
OT  - epidemiology
OT  - human immunodeficiency virus
OT  - hypersensitivity
COIS- None
EDAT- 2019/10/18 06:00
MHDA- 2019/11/13 06:00
PMCR- 2020/02/16
CRDT- 2019/10/18 06:00
PHST- 2019/10/18 06:00 [entrez]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2020/02/16 00:00 [pmc-release]
AID - NigerPostgradMedJ_2019_26_4_195_268597 [pii]
AID - 10.4103/npmj.npmj_75_19 [doi]
PST - ppublish
SO  - Niger Postgrad Med J. 2019 Oct-Dec;26(4):195-198. doi: 10.4103/npmj.npmj_75_19.