PMID- 31622560
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20210212
IS  - 1553-4014 (Electronic)
IS  - 1553-4006 (Linking)
VI  - 15
DP  - 2020 Jan 24
TI  - Molecular Pathogenesis of Membranous Nephropathy.
PG  - 287-313
LID - 10.1146/annurev-pathol-020117-043811 [doi]
AB  - Membranous nephropathy is a noninflammatory autoimmune disease of the kidney 
      glomerulus, characterized by the formation of immune deposits, 
      complement-mediated proteinuria, and risk of renal failure. Considerable advances 
      in understanding the molecular pathogenesis have occurred with the identification 
      of several antigens [neutral endopeptidase, phospholipase A2 receptor (PLA(2)R), 
      thrombospondin domain-containing 7A (THSD7A)] in cases arising from the neonatal 
      period to adulthood and the characterization of antibody-binding domains (that 
      is, epitopes). Immunization against PLA2R occurs in 70% to 80% of adult cases. 
      The development of highly specific and sensitive assays of circulating antibodies 
      has induced a paradigm shift in diagnosis and treatment monitoring. In addition, 
      several interacting loci in HLA-DQ, HLA-DR, and PLA2R1, as well as classical 
      human leukocyte antigen (HLA)-D alleles have been identified as being risk 
      factors, depending on a patient's ethnicity. Additionally, mechanisms of antibody 
      pathogenicity and pathways of complement activation are now better understood. 
      Further research is mandatory for designing new therapeutic strategies, including 
      the identifying triggering events, the molecular bases of remission and 
      progression, and the T cell epitopes involved.
FAU - Ronco, Pierre
AU  - Ronco P
AD  - Rare and Common Kidney Diseases: From Molecular Mechanisms to Personalized 
      Medicine Unit, INSERM UMRS 1155, Sorbonne Universite, 75020 Paris, France; email: 
      pierreronco@yahoo.fr.
FAU - Debiec, Hanna
AU  - Debiec H
AD  - Rare and Common Kidney Diseases: From Molecular Mechanisms to Personalized 
      Medicine Unit, INSERM UMRS 1155, Sorbonne Universite, 75020 Paris, France; email: 
      pierreronco@yahoo.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191017
PL  - United States
TA  - Annu Rev Pathol
JT  - Annual review of pathology
JID - 101275111
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Phospholipase A2)
RN  - 0 (THSD7A protein, human)
RN  - 0 (Thrombospondins)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - Disease Progression
MH  - Genetic Predisposition to Disease
MH  - Glomerulonephritis, Membranous/*genetics/*immunology/pathology
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Infant, Newborn
MH  - Neprilysin/immunology/metabolism
MH  - Receptors, Phospholipase A2/immunology/metabolism
MH  - Risk Factors
MH  - Thrombospondins/immunology/metabolism
OTO - NOTNLM
OT  - GWAS
OT  - HLA-D risk variants
OT  - THSD7A
OT  - genome-wide association studies
OT  - membrane attack complex of complement
OT  - neutral endopeptidase
OT  - phospholipase A2 receptor, PLA2R
OT  - thrombospondin domain-containing 7A
EDAT- 2019/10/18 06:00
MHDA- 2020/05/30 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - 10.1146/annurev-pathol-020117-043811 [doi]
PST - ppublish
SO  - Annu Rev Pathol. 2020 Jan 24;15:287-313. doi: 
      10.1146/annurev-pathol-020117-043811. Epub 2019 Oct 17.