PMID- 31622716
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 142
DP  - 2020 Jan 1
TI  - A biodegradable multifunctional porous microsphere composed of carrageenan for 
      promoting imageable trans-arterial chemoembolization.
PG  - 866-878
LID - S0141-8130(19)35185-2 [pii]
LID - 10.1016/j.ijbiomac.2019.10.026 [doi]
AB  - Trans-arterial chemoembolization (TACE) has been a mainstream treatment for 
      hepatocellular carcinoma (HCC), accordingly there are more requirements for 
      embolic agents' properties, mainly concentrated on biodegradability and imaging 
      function. A new kind of biodegradable multifunctional porous microspheres (BMPMs) 
      with internal coarse plications are ingeniously designed and manufactured, 
      consisting of carrageenan, inhexol and superparamagnetic iron oxide nanoparticle 
      (SPIO). BMPMs' sound roundness and excellent swelling behavior guarantee them to 
      be smoothly transported into appointed arteries' ends and achieve satisfactory 
      embolization effect. Porous structure together with sulphate groups on BMPMs' 
      skeleton weaved by cross-linked carrageenan contributes to a marvelous 
      doxorubicin hydrochloride (Dox) loading capacity over 45 mg Dox per mL of swollen 
      microspheres, as well as a controllable degradation rate by allowing enzymes to 
      infiltrate into BMPMs through holes, degrading 20-35% after two months in vitro. 
      Inner coarse plications enable BMPMs to effectively combine with iohexol via 
      hydrophilic effect and SPIO by blocking, which can further exhibit a decent 
      imaging performance under digital subtraction system (DSA) and magnetic resonance 
      imaging (MRI) for optimization of current TACE and development of a more advanced 
      imageable TACE (iTACE). Safety evaluation and animal experiment manifest that 
      BMPMs are reliable enough and hold great potential and competitiveness of being 
      used in curing HCC.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Kunliang, Liu
AU  - Kunliang L
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biological Sciences & Medical Engineering, Southeast 
      University, Nanjing 210096, China.
FAU - Zhicheng, Jin
AU  - Zhicheng J
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
FAU - Xiaolong, Hu
AU  - Xiaolong H
AD  - State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, 
      School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 
      210009, China.
FAU - Dan, Yan
AU  - Dan Y
AD  - Department of Pharmacy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer 
      Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 
      210009, China.
FAU - Yu, Zhang
AU  - Yu Z
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biological Sciences & Medical Engineering, Southeast 
      University, Nanjing 210096, China.
FAU - Haidong, Zhu
AU  - Haidong Z
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China; 
      State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, 
      School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 
      210009, China.
FAU - Gaojun, Teng
AU  - Gaojun T
AD  - State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, 
      School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 
      210009, China.
FAU - Fei, Xiong
AU  - Fei X
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biological Sciences & Medical Engineering, Southeast 
      University, Nanjing 210096, China. Electronic address: xiongfei@seu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191014
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Magnetite Nanoparticles)
RN  - 80168379AG (Doxorubicin)
RN  - 9000-07-1 (Carrageenan)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/pharmacology
MH  - Carcinoma, Hepatocellular/diagnostic imaging/drug therapy
MH  - Carrageenan/*chemistry
MH  - Cell Survival/drug effects
MH  - Doxorubicin/*chemistry/pharmacology
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Embolization, Therapeutic/*methods
MH  - Hemolysis/drug effects
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Indicators and Reagents/*chemistry
MH  - Liver Neoplasms/diagnostic imaging/drug therapy
MH  - Liver Neoplasms, Experimental
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetite Nanoparticles/*chemistry
MH  - Microspheres
MH  - Porosity
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Biodegradability
OT  - Imaging performance
OT  - Multifunctional embolic agent
OT  - iTACE
EDAT- 2019/10/18 06:00
MHDA- 2020/06/13 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/07/09 00:00 [received]
PHST- 2019/09/16 00:00 [revised]
PHST- 2019/10/01 00:00 [accepted]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - S0141-8130(19)35185-2 [pii]
AID - 10.1016/j.ijbiomac.2019.10.026 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jan 1;142:866-878. doi: 10.1016/j.ijbiomac.2019.10.026. 
      Epub 2019 Oct 14.