PMID- 31622873
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 281
DP  - 2019 Nov
TI  - Decreased regional homogeneity and increased functional connectivity of default 
      network correlated with neurocognitive deficits in subjects with genetic 
      high-risk for schizophrenia: A resting-state fMRI study.
PG  - 112603
LID - S0165-1781(19)31441-6 [pii]
LID - 10.1016/j.psychres.2019.112603 [doi]
AB  - The complex symptoms of schizophrenia (SCZ) have been associated with dysfunction 
      of the default mode network (DMN). Subjects at genetic high risk (GHR) for SCZ 
      exhibit similar but milder brain abnormalities. This study aimed to investigate 
      functional alterations of DMN from the local to the whole and their relationships 
      with cognitive deficits in GHR subjects. 42 GHR subjects and 38 matched healthy 
      controls (HC) were studied by resting-state functional magnetic resonance imaging 
      (rs-fMRI). Regional homogeneity (ReHo) analysis was performed to measure the 
      local brain function of the DMN, derived by the group independent component 
      analysis, and areas with aberrant ReHo were used as seeds in functional 
      connectivity (FC). Compared with the HC group, the GHR group exhibited 
      significantly decreased ReHo and increased FC in the fronto-limbic-striatal 
      system within the DMN. Furthermore, a significant negative correlation was found 
      between decreased ReHo in the right superior frontal gyrus and the delayed recall 
      in GHR subjects. Our findings revealed decreased local function and 
      hyper-connectivity in the fronto-limbic-striatal system of the DMN in GHR 
      subjects, which is associated with cognitive deficits. This may improve our 
      understanding of the neurophysiological endophenotypes of SCZ and the neural 
      substrate underlying the cognitive deficits of the disease.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Ma, Xiaoqian
AU  - Ma X
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Zheng, Wenxiao
AU  - Zheng W
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China; Department of Clinical Medicine, Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - Li, Chunwang
AU  - Li C
AD  - Department of Radiology, Hunan Children's Hospital, Changsha, China.
FAU - Li, Zongchang
AU  - Li Z
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Tang, Jinsong
AU  - Tang J
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Yuan, Liu
AU  - Yuan L
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Ouyang, Lijun
AU  - Ouyang L
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Jin, Ke
AU  - Jin K
AD  - Department of Radiology, Hunan Children's Hospital, Changsha, China.
FAU - He, Ying
AU  - He Y
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China. Electronic address: yinghe@csu.edu.cn.
FAU - Chen, Xiaogang
AU  - Chen X
AD  - Department of Psychiatry, Second Xiangya Hospital, Central South University, 
      Changsha, China; Mental Health Institute of Central South University, Changsha, 
      Hunan, China; China National Clinical Research Center on Mental Disorders 
      (Xiangya), Changsha, Hunan, China; China National Technology Institute on Mental 
      Disorders, Changsha, Hunan, China; Hunan Key Laboratory of Psychiatry and Mental 
      Health, Changsha, Hunan, China. Electronic address: chenxiaogang@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191007
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*diagnostic imaging/physiopathology
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/*diagnostic imaging/physiopathology
MH  - Rest
MH  - Risk Factors
MH  - Schizophrenia/*diagnostic imaging/*genetics/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Default mode network
OT  - Functional connectivity
OT  - Genetic high risk
OT  - Regional homogeneity
OT  - Resting-state
OT  - Schizophrenia
EDAT- 2019/10/18 06:00
MHDA- 2020/04/21 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/07/04 00:00 [received]
PHST- 2019/10/04 00:00 [revised]
PHST- 2019/10/04 00:00 [accepted]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - S0165-1781(19)31441-6 [pii]
AID - 10.1016/j.psychres.2019.112603 [doi]
PST - ppublish
SO  - Psychiatry Res. 2019 Nov;281:112603. doi: 10.1016/j.psychres.2019.112603. Epub 
      2019 Oct 7.