PMID- 31623025
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 11
DP  - 2019 Nov
TI  - Probiotic extracts ameliorate nasal allergy by inducing interleukin-35-producing 
      dendritic cells in mice.
PG  - 1289-1296
LID - 10.1002/alr.22438 [doi]
AB  - BACKGROUND: The therapeutic efficacy of allergic rhinitis (AR) needs to be 
      improved. Probiotics have immunoregulatory functions. In this study we evaluated 
      the effects of protein extracts of probiotics in the amelioration of AR. METHODS: 
      Extracts of Bifidobacterium infantis (EBI) were prepared by lysing the live 
      probiotics. AR mice were developed to be used to evaluate the therapeutic 
      efficacy of EBI. RESULTS: The results show that EBI induced interleukin 
      (IL)-10-producing dendritic cells (DCs) via increasing IL-35 and signal 
      transducer and activator of transcription 3 (STAT3) phosphorylation. 
      IL-10-expressing DCs induced IL-10-producing B cells (B10 cells), with the latter 
      showing immunosuppressive functions. After challenge with specific antigens, AR 
      mice showed sneezing, nasal itch, and increases in serum-specific immunoglobulin 
      E (IgE) and mouse mast cell protease-1; higher levels of T helper 2 (Th2) 
      cytokines (IL-4, 67.17 +/- 10.66; IL-5, 62.83 +/- 9.70; IL-13, 51.00 +/- 6.69, before 
      treatment) in nasal mucosal protein extracts, which were significantly suppressed 
      (IL-4, 27.00 +/- 6.66; IL-5, 23.86 +/- 4.53; IL-13, 25.67 +/- 4.93, after treatment (p 
      < 0.001) by administration with EBI nasal drops. CONCLUSION: EBI can suppress AR 
      via inducing B10 cells. Thus, after carrying out required preclinical experiments 
      and tests, EBI has the translational potential to be used in the treatment of AR 
      and other allergic diseases.
CI  - (c) 2019 ARS-AAOA, LLC.
FAU - Xue, Jin-Mei
AU  - Xue JM
AD  - Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Ma, Fei
AU  - Ma F
AD  - Research Center of Allergy & Immunology, Shenzhen University School of Medicine, 
      Shenzhen, China.
AD  - Department of Otolaryngology, Head & Neck Surgery, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - An, Yun-Fang
AU  - An YF
AD  - Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Suo, Li-Min
AU  - Suo LM
AD  - Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Geng, Xiao-Rui
AU  - Geng XR
AD  - Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Song, Yan-Nan
AU  - Song YN
AD  - Research Center of Allergy & Immunology, Shenzhen University School of Medicine, 
      Shenzhen, China.
FAU - Mo, Li-Hua
AU  - Mo LH
AD  - Department of Pediatrics, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Luo, Xiang-Qian
AU  - Luo XQ
AD  - Department of Pediatrics, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Zhang, Xiao-Wen
AU  - Zhang XW
AD  - Department of Otolaryngology, Head & Neck Surgery, First Affiliated Hospital, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Liu, Da-Bo
AU  - Liu DB
AD  - Department of Pediatrics, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Zhao, Chang-Qing
AU  - Zhao CQ
AD  - Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Yang, Ping-Chang
AU  - Yang PC
AUID- ORCID: 0000-0002-3650-0416
AD  - Research Center of Allergy & Immunology, Shenzhen University School of Medicine, 
      Shenzhen, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191017
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Cell Extracts)
RN  - 0 (Interleukins)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (interleukin-35, mouse)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*immunology
MH  - Bifidobacterium longum subspecies infantis/*metabolism
MH  - Cell Extracts/*therapeutic use
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukins/*metabolism
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Probiotics
MH  - Rhinitis, Allergic/*therapy
MH  - STAT3 Transcription Factor/metabolism
OTO - NOTNLM
OT  - B cell
OT  - allergic rhinitis
OT  - dendritic cell
OT  - nasal mucosa
OT  - probiotics
EDAT- 2019/10/18 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/10/18 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/08/22 00:00 [revised]
PHST- 2019/09/03 00:00 [accepted]
PHST- 2019/10/18 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/10/18 06:00 [entrez]
AID - 10.1002/alr.22438 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Nov;9(11):1289-1296. doi: 10.1002/alr.22438. Epub 
      2019 Oct 17.