PMID- 31623352
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 19
DP  - 2019 Oct 3
TI  - The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial 
      Function in Patients with Type 2 Diabetes Mellitus.
LID - 10.3390/ijms20194909 [doi]
LID - 4909
AB  - The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may 
      be a reasonable index for assessing endothelial dysfunction in type 2 diabetes 
      mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level 
      is correlated with the endothelial function using the Endo-PAT(TM), a newly 
      developed device, in patients with T2DM. A total of 63 patients with T2DM (mean 
      age: 59 years old) were enrolled in the study. The patients' serum Lp(a) and 
      oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The 
      reactive hyperemia index (RHI) level was measured using an Endo-PAT(TM) 2000. A 
      correlation analysis between the measured variables was conducted. Among the 
      patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 
      0.28 (interquartile range: 0.07-0.54), and the mean RHI was 1.8 (standard 
      deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) 
      level was an independent, significant, and inverse variable for the RHI level (beta 
      = -0.26, p < 0.05), along with male gender. A high oxLp(a)/Lp(a) level may 
      reflect endothelial dysfunction, as assessed by the Endo-PAT(TM), in patients 
      with T2DM. Further studies are warranted to confirm the observed findings.
FAU - Kotani, Kazuhiko
AU  - Kotani K
AD  - Division of Community and Family Medicine, Department of Clinical Laboratory 
      Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan. 
      kazukotani@jichi.ac.jp.
AD  - Department of Clinical Laboratory Medicine, Jichi Medical University, 
      Shimotsuke-City, Tochigi 329-0498, Japan. kazukotani@jichi.ac.jp.
FAU - Yamada, Shingo
AU  - Yamada S
AD  - Central Laboratory, Shino-Test, Sagamihara-City, Kanagawa 252-0331, Japan. 
      shingo.yamada@shino-test.co.jp.
FAU - Takahashi, Hirokazu
AU  - Takahashi H
AD  - Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 
      Saga-City, Saga 849-8501, Japan. takahas2@cc.saga-u.ac.jp.
FAU - Iwazu, Yoshitaka
AU  - Iwazu Y
AD  - Department of Clinical Laboratory Medicine, Jichi Medical University, 
      Shimotsuke-City, Tochigi 329-0498, Japan. iwazu@jichi.ac.jp.
FAU - Yamada, Toshiyuki
AU  - Yamada T
AD  - Department of Clinical Laboratory Medicine, Jichi Medical University, 
      Shimotsuke-City, Tochigi 329-0498, Japan. yamadanji@jichi.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20191003
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers
MH  - Child
MH  - Diabetes Mellitus, Type 2/etiology/*metabolism
MH  - Disease Susceptibility
MH  - Endothelium, Vascular/*metabolism
MH  - Female
MH  - Humans
MH  - Lipoproteins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Oxidation-Reduction
MH  - Young Adult
PMC - PMC6801959
OTO - NOTNLM
OT  - Endo-PAT
OT  - Lp(a)
OT  - atherosclerosis
OT  - endothelium
OT  - oxidative stress
OT  - reactive hyperemia
COIS- The authors declare that they have no competing interests.
EDAT- 2019/10/19 06:00
MHDA- 2020/02/25 06:00
PMCR- 2019/10/01
CRDT- 2019/10/19 06:00
PHST- 2019/08/30 00:00 [received]
PHST- 2019/10/01 00:00 [revised]
PHST- 2019/10/03 00:00 [accepted]
PHST- 2019/10/19 06:00 [entrez]
PHST- 2019/10/19 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - ijms20194909 [pii]
AID - ijms-20-04909 [pii]
AID - 10.3390/ijms20194909 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Oct 3;20(19):4909. doi: 10.3390/ijms20194909.