PMID- 31625697
OWN - NLM
STAT- MEDLINE
DCOM- 20191107
LR  - 20200108
IS  - 0019-1442 (Print)
IS  - 0019-1442 (Linking)
VI  - 72
IP  - 9-10
DP  - 2019 Sep 30
TI  - [Newer studies on the strong link between sleep and epilepsy: Epilepsy as an 
      epileptic transformation of sleep plastic functions].
PG  - 304-314
LID - 10.18071/isz.72.0304 [doi]
AB  - Aims - Overview of the new data about the strong link of sleep and epilepsy and 
      conjoining cognitive impairment. Methods - Search for relevant references and 
      summary of our own research activity on the topic. Results - Strong 
      interrealtionship exists between epilepsy and plastic brain functions (memory 
      processing and synaptic homeostasis) and the working modes of NREM sleep. In the 
      most frequent childhood and adult epilepsy networks responsible for plastic 
      functions can be derailed to an epileptic level of excitability, and suffer a 
      transitory or permanent epileptic transformation. Exampling on the three big 
      epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood 
      idiopathic focal age dependent epilepsy spectrum we demonstrate the most 
      important features of this epileptic transformation. The association of cognitive 
      impairment to certain sleep dependent epilepsies gains explanation by the 
      epilepsy caused interference with slow wave decline (ICFE) and memory 
      consolidation (MTLE) during NREM sleep. This paper serves also to introduce the 
      concept of sleep dependent system epilepsies. Conclusions - We provide evidences 
      about shared mechanisms among sleep related epilepsies being the derailment of 
      sleep plastic funcions toward exaggerated excitability determined by the inherent 
      possibilities of the signal transduction properties.
FAU - Halasz, Peter
AU  - Halasz P
AD  - Orszagos Klinikai Idegtudomanyi Intezet, Budapest.
LA  - hun
PT  - Journal Article
PT  - Review
TT  - Az alvas es az epilepszia szoros kapcsolatanak ujabb vizsgalatai: az epilepszia 
      mint az alvasi plaszticitasfunkcio epilepszias transzformacioja.
PL  - Hungary
TA  - Ideggyogy Sz
JT  - Ideggyogyaszati szemle
JID - 17510500R
RN  - 0 (Plastics)
SB  - IM
MH  - Adult
MH  - Child
MH  - Cognitive Dysfunction/*physiopathology
MH  - Electroencephalography
MH  - Epilepsies, Partial/*physiopathology
MH  - Epilepsy/*physiopathology
MH  - Humans
MH  - Plastics
MH  - Sleep/*physiology
MH  - Sleep Stages/physiology
OTO - NOTNLM
OT  - absence epilepsy
OT  - age dependent epileptic hyperexcitability; cognitive impairment
OT  - medial temporal lobe epilepsy; idiopathic focal
OT  - memory consolidation
OT  - plasticity; NREM sleep; system-epilepsy; synaptic homeostasis
EDAT- 2019/10/19 06:00
MHDA- 2019/11/08 06:00
CRDT- 2019/10/19 06:00
PHST- 2019/10/19 06:00 [entrez]
PHST- 2019/10/19 06:00 [pubmed]
PHST- 2019/11/08 06:00 [medline]
AID - 10.18071/isz.72.0304 [doi]
PST - ppublish
SO  - Ideggyogy Sz. 2019 Sep 30;72(9-10):304-314. doi: 10.18071/isz.72.0304.