PMID- 31626387
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr
TI  - Depressive symptoms mediate the relationship between sleep disturbances and type 
      2 diabetes mellitus.
PG  - 305-314
LID - 10.1111/1753-0407.12996 [doi]
AB  - BACKGROUND: The current study aimed at examining whether individuals diagnosed 
      with type 2 diabetes mellitus (T2DM) have more severe sleep disturbances compared 
      to individuals who are healthy or have prediabetes and whether depressive 
      symptoms mediate the relationship between sleep disturbances and having T2DM. 
      METHODS: T2DM patients (n = 107) were compared to individuals with prediabetes (n 
      = 48) and healthy individuals (n = 154) regarding the severity of depressive 
      symptoms, measured via the Beck Depression Inventory-II (BDI-II), and sleep 
      disturbances, measured via the Mini Sleep Questionnaire (MSQ). Mediation analysis 
      examined whether depressive symptoms mediated the relationship between sleep 
      disturbances and T2DM. RESULTS: Compared to healthy individuals and individuals 
      with prediabetes, T2DM patients had more depressive symptoms and higher levels of 
      insomnia, hypersomnia, and overall more sleep disturbances. The prediabetes group 
      did not differ from the healthy control group on these measures, and these groups 
      were thus combined for further analysis. Sleep disturbances were correlated with 
      severity of depressive symptoms (r =0.43). After controlling for age, gender, and 
      ethnic background, both severity of sleep disturbances (odds ratio [OR]: 1.04; 
      95% CI: 1.01-1.07, P <.001) and severity of depressive symptoms (OR: 8.54, 95% 
      CI: 3.37-21.69, P <.001) predicted T2DM. Depression symptoms mediated the 
      relationship between sleep disturbances and T2DM, whereas the direct relationship 
      between sleep disturbances and T2DM was nonsignificant. CONCLUSIONS: The findings 
      imply that sleep disturbances may contribute to the development and progression 
      of T2DM by promoting depressive symptoms. Thus, treatments for the emotional 
      distress associated with sleep disturbances may help reduce the risk for T2DM and 
      the progression of the disease.
CI  - (c) 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Peleg, Ora
AU  - Peleg O
AD  - Department of Education, The Max Stern Yezreel Valley College, Emek Yezreel, 
      Israel.
FAU - Cohen, Ami
AU  - Cohen A
AUID- ORCID: 0000-0003-2766-1848
AD  - Department of Psychology, The Max Stern Yezreel Valley College, Emek Yezreel, 
      Israel.
FAU - Haimov, Iris
AU  - Haimov I
AD  - Department of Psychology, The Max Stern Yezreel Valley College, Emek Yezreel, 
      Israel.
LA  - eng
GR  - Max Stern Yezreel Valley College, Emek Yezreel, Israel/
PT  - Journal Article
DEP - 20191114
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Depressive Disorder/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*physiopathology
MH  - Severity of Illness Index
MH  - Sleep Wake Disorders/*physiopathology
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - 2型糖尿病
OT  - depression
OT  - diabetes mellitus type 2
OT  - sleep
OT  - sleep disturbances
OT  - 抑郁
OT  - 睡眠
OT  - 睡眠障碍
EDAT- 2019/10/19 06:00
MHDA- 2021/01/05 06:00
CRDT- 2019/10/19 06:00
PHST- 2019/05/23 00:00 [received]
PHST- 2019/08/25 00:00 [revised]
PHST- 2019/10/14 00:00 [accepted]
PHST- 2019/10/19 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2019/10/19 06:00 [entrez]
AID - 10.1111/1753-0407.12996 [doi]
PST - ppublish
SO  - J Diabetes. 2020 Apr;12(4):305-314. doi: 10.1111/1753-0407.12996. Epub 2019 Nov 
      14.