PMID- 31626561
OWN - NLM
STAT- MEDLINE
DCOM- 20200730
LR  - 20200730
IS  - 1527-1323 (Electronic)
IS  - 0271-5333 (Linking)
VI  - 39
IP  - 7
DP  - 2019 Nov-Dec
TI  - Imaging Features of Primary Sclerosing Cholangitis: From Diagnosis to Liver 
      Transplant Follow-up.
PG  - 1938-1964
LID - 10.1148/rg.2019180213 [doi]
AB  - Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory 
      disease of the bile ducts that leads to multifocal bile duct fibrosis, 
      strictures, cholestasis, liver parenchymal changes, and ultimately cirrhosis. It 
      more commonly occurs in young adults, with a variety of clinical and imaging 
      manifestations. The cause of the disease is not known, but it has a strong 
      association with inflammatory bowel disease and can overlap with other autoimmune 
      diseases, including autoimmune hepatitis and immunoglobulin G4-related disease. 
      Patients are predisposed to various hepatic and extrahepatic deteriorating 
      complications, such as bile duct and gallbladder calculi, acute bacterial 
      cholangitis, liver abscess, and portal hypertension, as well as malignancies 
      including cholangiocarcinoma (CCA), gallbladder cancer, and colorectal carcinoma. 
      Imaging has an essential role in diagnosis, surveillance, and detection of 
      complications. MR cholangiopancreatography and endoscopic retrograde 
      cholangiopancreatography have high specificity and sensitivity for detection of 
      primary disease and assessment of disease progression. However, many patients 
      with PSC are still diagnosed incidentally at US or CT. Novel imaging techniques 
      such as transient elastography and MR elastography are used to survey the grade 
      of liver fibrosis. Annual cancer surveillance is necessary in all PSC patients to 
      screen for CCA and gallbladder cancer. Familiarity with PSC pathogenesis and 
      imaging features across various classic imaging modalities and novel imaging 
      techniques can aid in correct imaging diagnosis and guide appropriate management. 
      The imaging features of the biliary system and liver parenchyma in PSC across 
      various imaging modalities are reviewed. Imaging characteristics of the 
      differential diagnosis of PSC, clinical associations, and complications are 
      described. Finally, the role of imaging in evaluation of PSC progression, 
      pre-liver transplant assessment, and post-liver transplant disease recurrence are 
      discussed.((c))RSNA, 2019.
FAU - Khoshpouri, Pegah
AU  - Khoshpouri P
AUID- ORCID: 0000-0002-2996-4183
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Habibabadi, Roya Rezvani
AU  - Habibabadi RR
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Hazhirkarzar, Bita
AU  - Hazhirkarzar B
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Ameli, Sanaz
AU  - Ameli S
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Ghadimi, Maryam
AU  - Ghadimi M
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Ghasabeh, Mounes Aliyari
AU  - Ghasabeh MA
AUID- ORCID: 0000-0001-7253-9310
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Menias, Christine O
AU  - Menias CO
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Kim, Amy
AU  - Kim A
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Li, Zhiping
AU  - Li Z
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
FAU - Kamel, Ihab R
AU  - Kamel IR
AUID- ORCID: 0000-0003-0511-7796
AD  - From the Russell H. Morgan Department of Radiology and Radiological Sciences, 
      Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, 
      Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); 
      and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Webcast
DEP - 20191018
PL  - United States
TA  - Radiographics
JT  - Radiographics : a review publication of the Radiological Society of North 
      America, Inc
JID - 8302501
RN  - 724L30Y2QR (Ursodeoxycholic Acid)
SB  - IM
MH  - Bile Ducts/diagnostic imaging
MH  - Biopsy
MH  - Cholangiopancreatography, Endoscopic Retrograde/methods
MH  - Cholangiopancreatography, Magnetic Resonance/methods
MH  - Cholangitis, Sclerosing/complications/*diagnostic imaging/pathology/surgery
MH  - Diagnosis, Differential
MH  - Digestive System Neoplasms/diagnostic imaging/etiology
MH  - Disease Progression
MH  - Disease Susceptibility
MH  - Elasticity Imaging Techniques/methods
MH  - Humans
MH  - Immunoglobulin G4-Related Disease/diagnostic imaging
MH  - Inflammatory Bowel Diseases/complications/diagnostic imaging
MH  - Liver/pathology
MH  - Liver Cirrhosis/diagnostic imaging/etiology/surgery
MH  - Liver Transplantation
MH  - Recurrence
MH  - Tomography, X-Ray Computed/methods
MH  - Ultrasonography/methods
MH  - Ursodeoxycholic Acid/therapeutic use
EDAT- 2019/10/19 06:00
MHDA- 2020/07/31 06:00
CRDT- 2019/10/19 06:00
PHST- 2019/10/19 06:00 [pubmed]
PHST- 2020/07/31 06:00 [medline]
PHST- 2019/10/19 06:00 [entrez]
AID - 10.1148/rg.2019180213 [doi]
PST - ppublish
SO  - Radiographics. 2019 Nov-Dec;39(7):1938-1964. doi: 10.1148/rg.2019180213. Epub 
      2019 Oct 18.