PMID- 31627371
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 11
IP  - 10
DP  - 2019 Oct 17
TI  - The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables 
      Population-Level Virus Control.
LID - 10.3390/v11100959 [doi]
LID - 959
AB  - Viruses and natural killer (NK) cells have a long co-evolutionary history, 
      evidenced by patterns of specific NK gene frequencies in those susceptible or 
      resistant to infections. The killer immunoglobulin-like receptors (KIR) and their 
      human leukocyte antigen (HLA) ligands together form the most polymorphic 
      receptor-ligand partnership in the human genome and govern the process of NK cell 
      education. The KIR and HLA genes segregate independently, thus creating an array 
      of reactive potentials within and between the NK cell repertoires of individuals. 
      In this review, we discuss the interplay between NK cell education and adaptation 
      with virus infection, with a special focus on three viruses for which the NK cell 
      response is often studied: human immunodeficiency virus (HIV), hepatitis C virus 
      (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the 
      complex co-evolution of viruses and NK cells, and their impact on viral control.
FAU - Savoy, Sarah K A
AU  - Savoy SKA
AD  - Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 
      4R5, Canada. sarah.ka.savoy@dal.ca.
FAU - Boudreau, Jeanette E
AU  - Boudreau JE
AUID- ORCID: 0000-0003-0203-2180
AD  - Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 
      4R5, Canada. Jeanette.boudreau@dal.ca.
AD  - Department of Pathology, Dalhousie University, Halifax, NS B3H 4R5, Canada. 
      Jeanette.boudreau@dal.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191017
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - *Biological Coevolution
MH  - Cytomegalovirus/genetics/immunology
MH  - Genetic Variation
MH  - Genotype
MH  - HIV-1/genetics/immunology
MH  - HLA Antigens/immunology
MH  - Hepacivirus/genetics/immunology
MH  - Host Microbial Interactions/genetics/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Receptors, KIR/immunology
MH  - Viruses/*genetics/*immunology
PMC - PMC6832630
OTO - NOTNLM
OT  - HIV
OT  - HLA
OT  - KIR
OT  - cytomegalovirus
OT  - education
OT  - hepatitis C
OT  - human leukocyte antigens
OT  - immunogenetics
OT  - killer immunoglobulin-like receptors
OT  - licensing
OT  - natural killer cells
OT  - virus infection
COIS- The authors declare that no conflicts of interest exist.
EDAT- 2019/10/20 06:00
MHDA- 2020/09/29 06:00
PMCR- 2019/10/01
CRDT- 2019/10/20 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2019/10/11 00:00 [revised]
PHST- 2019/10/14 00:00 [accepted]
PHST- 2019/10/20 06:00 [entrez]
PHST- 2019/10/20 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - v11100959 [pii]
AID - viruses-11-00959 [pii]
AID - 10.3390/v11100959 [doi]
PST - epublish
SO  - Viruses. 2019 Oct 17;11(10):959. doi: 10.3390/v11100959.