PMID- 31627723
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 20
IP  - 1
DP  - 2019 Oct 18
TI  - The effect of mobilization with movement on pain and function in patients with 
      knee osteoarthritis: a randomized double-blind controlled trial.
PG  - 452
LID - 10.1186/s12891-019-2841-4 [doi]
LID - 452
AB  - BACKGROUND: Few studies have investigated the effects of mobilization with 
      movement (MWM) in patients with knee osteoarthritis (OA) compared to other 
      procedures. Sham procedures are generally more appropriate control than using no 
      or usual treatments. Moreover, studies investigating the widespread hypoalgesic 
      effects of MWM in patients with knee OA are lacking. The aim was to investigate 
      the effect of MWM on function and pain in patients with knee OA compared to sham 
      MWM. METHODS: This is a randomized double-blind (patients and assessor) 
      controlled trial. Forty adult patients with knee OA of grade II and above were 
      recruited to receive either MWM treatment or sham MWM for the knee. The outcome 
      measures included the following: a visual analogue scale (VAS) for pain, the 
      pressure pain threshold (PPT) test, the Western Ontario and McMaster Universities 
      Osteoarthritis (WOMAC) Index, the timed up and go (TUG) test, knee strength and 
      knee range of motion (ROM). The measurements were taken at baseline, immediately 
      after intervention and 2 days later. RESULTS: Compared with sham MWM, MWM 
      resulted in greater immediate improvement in pain [mean difference (95% CI): 
      - 2.2 (- 2.8, - 1.6)], PPT at both the knee [176 (97, 254)] and shoulder [212 
      (136, 288)], TUG time [- 1.6 (- 2.1, - 1.1)], knee flexor strength [2.0 (1.3, 
      2.7)] and extensor strength [5.7 (4.1, 7.2)] and knee flexion ROM [12.8 (9.6, 
      15.9)] (all, p < 0.001) but not knee extension ROM [- 0.8 (- 1.6, 0.1)] 
      (p = 0.067). After 2 days of intervention, patients who received MWM also 
      demonstrated a greater improvement in pain [- 1.0 (- 1.8, - 0.1)], PPT at the 
      shoulder [107 (40, 175)], TUG time [- 0.9 (- 1.4, - 0.4)], knee flexor strength 
      [0.9 (0.2, 1.7)] and extensor strength [2.9 (2.1, 3.9)] and knee flexion ROM [8.3 
      (4.7, 11.9)] (all, p </= 0.026). However, WOMAC scores and knee extension ROM 
      showed no evidence of change at any stage after intervention (p >/= 0.067). 
      CONCLUSIONS: MWM provided superior benefits over sham MWM in terms of local and 
      widespread pain, physical function (walking), knee flexion and extension muscle 
      strength and knee flexion ROM for at least 2 days in patients with knee OA. TRIAL 
      REGISTRATION: ClinicalTrials.gov ( NCT02865252 ), registered on August 12, 2016.
FAU - Alkhawajah, Hani A
AU  - Alkhawajah HA
AUID- ORCID: 0000-0001-5601-8240
AD  - Department of Physiotherapy, King Fahd Hospital of the University, Imam 
      Abdulrahman Bin Faisal University, P.O Box 40244, Khobar, 31952, Saudi Arabia. 
      hkhawajah@iau.edu.sa.
FAU - Alshami, Ali M
AU  - Alshami AM
AD  - Department of Physical Therapy, College of Applied Medical Sciences, Imam 
      Abdulrahman Bin Faisal University, P.O. Box 2435, Dammam, 31441, Saudi Arabia.
LA  - eng
SI  - ClinicalTrials.gov/NCT02865252
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20191018
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Arthralgia/diagnosis/etiology/*therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Knee Joint/*physiopathology
MH  - Male
MH  - Manipulation, Orthopedic/*methods
MH  - Middle Aged
MH  - Osteoarthritis, Knee/complications/physiopathology/*therapy
MH  - Pain Measurement
MH  - *Range of Motion, Articular
MH  - Treatment Outcome
PMC - PMC6800493
OTO - NOTNLM
OT  - Hypoalgesia
OT  - Manual therapy
OT  - Pressure pain threshold
OT  - Quantitative sensory testing
COIS- The authors declare that they have no competing interests.
EDAT- 2019/10/20 06:00
MHDA- 2020/02/25 06:00
PMCR- 2019/10/18
CRDT- 2019/10/20 06:00
PHST- 2018/10/19 00:00 [received]
PHST- 2019/09/20 00:00 [accepted]
PHST- 2019/10/20 06:00 [entrez]
PHST- 2019/10/20 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/10/18 00:00 [pmc-release]
AID - 10.1186/s12891-019-2841-4 [pii]
AID - 2841 [pii]
AID - 10.1186/s12891-019-2841-4 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2019 Oct 18;20(1):452. doi: 10.1186/s12891-019-2841-4.