PMID- 31627821
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 1089
DP  - 2019 Dec 16
TI  - Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes 
      for selective recognition and preconcentration of metformin in biological fluids 
      prior to its sensitive chemiluminescence determination: Central composite design 
      optimization.
PG  - 78-89
LID - S0003-2670(19)31037-2 [pii]
LID - 10.1016/j.aca.2019.08.070 [doi]
AB  - Novel molecularly imprinted polymer (MIP) for metformin was synthesized on the 
      surface of magnetic multi-walled carbon nanotubes (MMWCNTs) as the support. 
      Metformin was used as the template, methacrylic acid (MAA) as the functional 
      monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 
      2,2'-azoisobutyronitrile (AIBN) as the initiator. The synthesized composite was 
      characterized by field emission scanning electron microscopy (FESEM), X-ray 
      diffraction (XRD), vibrating sample magnetometer (VSM), and Fourier transform 
      infrared spectroscopy (FTIR). The surface molecularly imprinted composite was 
      used for magnetic solid phase microextraction (MSPME) of metformin before its 
      chemiluminescence (CL) determination and its capability was compared with 
      non-imprinted polymer (NIP). The central composite design was used for 
      optimization as well as consideration of possible interaction of effective 
      variables on extraction. Under the optimized conditions, the developed method 
      exhibited the linear dynamic range of 0.5-50.0 mug L(-1) with a detection limit of 
      0.13 mug L(-1) and enhancement factor of 195.3 for the preconcentration of 100 mL 
      of the sample and 500 muL of an eluent. The intra- and inter-day relative standard 
      deviations (RSD%) at 5.0 mug L(-1) level of metformin (n = 6) were 3.7 and 4.9%, 
      respectively. The maximum adsorption capacity of the sorbent was found to be 
      80.0 mg g(-1), the adsorption of metformin was endothermic and spontaneous and 
      followed the Langmuir isotherm model. The adsorption kinetic was also found to be 
      best fitted with the pseudo-second-order model. The designed method was 
      successfully applied to the extraction and determination of metformin in 
      biological fluids and water samples.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Toudeshki, Reza Mohammadi
AU  - Toudeshki RM
AD  - Department of Chemistry, Yazd University, 89195-741, Yazd, Iran.
FAU - Dadfarnia, Shayessteh
AU  - Dadfarnia S
AD  - Department of Chemistry, Yazd University, 89195-741, Yazd, Iran. Electronic 
      address: sdadfarnia@yazd.ac.ir.
FAU - Haji Shabani, Ali Mohammad
AU  - Haji Shabani AM
AD  - Department of Chemistry, Yazd University, 89195-741, Yazd, Iran. Electronic 
      address: hshabani@yazd.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20190924
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Drinking Water)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Polymethacrylic Acids)
RN  - 0 (Water Pollutants, Chemical)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adsorption
MH  - Drinking Water/analysis
MH  - Kinetics
MH  - Limit of Detection
MH  - Metformin/*analysis/blood/urine
MH  - Molecular Imprinting
MH  - Nanotubes, Carbon/*chemistry
MH  - Polymethacrylic Acids/chemical synthesis/chemistry
MH  - Seawater/analysis
MH  - Solid Phase Microextraction/*methods
MH  - Water Pollutants, Chemical/*analysis/blood/urine
OTO - NOTNLM
OT  - Chemiluminescence determination
OT  - Magnetic multi-walled carbon nanotubes
OT  - Magnetic solid phase microextraction
OT  - Metformin
OT  - Molecularly imprinted polymer
EDAT- 2019/10/20 06:00
MHDA- 2020/02/25 06:00
CRDT- 2019/10/20 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2019/08/27 00:00 [revised]
PHST- 2019/08/30 00:00 [accepted]
PHST- 2019/10/20 06:00 [entrez]
PHST- 2019/10/20 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
AID - S0003-2670(19)31037-2 [pii]
AID - 10.1016/j.aca.2019.08.070 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2019 Dec 16;1089:78-89. doi: 10.1016/j.aca.2019.08.070. Epub 2019 
      Sep 24.