PMID- 31628552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2199-1162 (Print)
IS  - 2198-977X (Electronic)
IS  - 2199-1162 (Linking)
VI  - 6
IP  - 1
DP  - 2019 Oct 18
TI  - Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with 
      Empagliflozin: A Case Report.
PG  - 11
LID - 10.1007/s40800-019-0105-8 [doi]
LID - 11
AB  - Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been reported as possibly 
      associated with Fournier's gangrene (FG). This case report describes a 
      34-year-old Japanese man who was diagnosed with FG after the administration of 
      empagliflozin for type 2 diabetes mellitus (T2DM). He presented with pain and 
      swelling in the perineum and groin 142 days after initiating empagliflozin. The 
      clinical features, laboratory data, and computed tomographic findings were 
      consistent with FG. Surgical drainage and debridement of necrotic tissues were 
      performed immediately after admission to our hospital. The patient had no 
      complications of diabetes before the onset of FG. Glycemic management was good at 
      the time of FG onset. This case suggests a possible association between 
      empagliflozin and FG. We report a case of FG in a patient during a period of good 
      glycemic management following treatment with empagliflozin. We recommend further 
      awareness of this relationship and suggest the need for additional research.
FAU - Nagano, Yasunori
AU  - Nagano Y
AUID- ORCID: 0000-0002-5746-8937
AD  - Department of Pharmacy, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 
      1018326, Japan. nagano8931@sanraku.or.jp.
FAU - Yakame, Naomi Kashiwagi
AU  - Yakame NK
AD  - Department of Pharmacy, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 
      1018326, Japan.
FAU - Aoki, Hisae
AU  - Aoki H
AD  - Department of Surgery, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 
      1018326, Japan.
FAU - Yamakawa, Tamaki
AU  - Yamakawa T
AD  - Department of Endocrinology and Metabolism, Sanraku Hospital, 2-5 Kandasurugadai, 
      Chiyoda-ku, Tokyo, 1018326, Japan.
FAU - Kondo, Naoko Iwahashi
AU  - Kondo NI
AUID- ORCID: 0000-0001-6881-3807
AD  - Department of Surgery, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 
      1018326, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191018
PL  - Switzerland
TA  - Drug Saf Case Rep
JT  - Drug safety - case reports
JID - 101674544
PMC - PMC6800415
COIS- Yasunori Nagano, Naomi Kashiwagi Yakame, Hisae Aoki, Tamaki Yamakawa, and Naoko 
      Iwahashi Kondo have no conflicts of interest that are directly relevant to the 
      content of this case report.
EDAT- 2019/10/20 06:00
MHDA- 2019/10/20 06:01
PMCR- 2019/10/18
CRDT- 2019/10/20 06:00
PHST- 2019/10/20 06:00 [entrez]
PHST- 2019/10/20 06:00 [pubmed]
PHST- 2019/10/20 06:01 [medline]
PHST- 2019/10/18 00:00 [pmc-release]
AID - 10.1007/s40800-019-0105-8 [pii]
AID - 105 [pii]
AID - 10.1007/s40800-019-0105-8 [doi]
PST - epublish
SO  - Drug Saf Case Rep. 2019 Oct 18;6(1):11. doi: 10.1007/s40800-019-0105-8.