PMID- 31630462
OWN - NLM
STAT- MEDLINE
DCOM- 20200514
LR  - 20200514
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 63
IP  - 1
DP  - 2020 Jan
TI  - Time to and differential time to blood culture positivity for assessing 
      catheter-related yeast fungaemia: A longitudinal, 7-year study in a single 
      university hospital.
PG  - 95-103
LID - 10.1111/myc.13024 [doi]
AB  - BACKGROUND: Time to positivity (TTP) and differential time to positivity (DTTP) 
      between central and peripheral blood cultures are commonly used for bacteraemia 
      to evaluate the likelihood of central venous catheter (CVC)-related bloodstream 
      infection. Few studies have addressed these approaches to yeast fungaemia. 
      OBJECTIVES: This study aimed to evaluate TTP and DTTP to assess CVC-related yeast 
      fungaemia (CVC-RYF). PATIENTS/METHODS: We retrospectively analysed the results 
      from 105 adult patients with incident fungaemia, with CVC removed and cultured, 
      collected from 2010 to 2017. The bottles were incubated in a BioMerieux 
      BacT/ALERT 3D and kept for at least 5 days. RESULTS: Of the 105 patients 
      included, most were oncology patients (85.7%) and had of long-term CVC (79.6%); 
      32 (30.5%) had a culture-positive CVC (defined as CVC-RYF) with the same species 
      as in blood culture, and 69.5% had culture-negative CVC (defined as non-CVC-RYF, 
      NCVC-RYF). Candida albicans represented 46% of the episodes. The median TTP was 
      statistically different between CVC-RYF and NCVC-RYF (16.8 hours interquartile 
      range (IQR) [9.7-28.6] vs 29.4 hours [IQR 20.7-41.3]; P = .001). A TTP <10 hours 
      had the best positive likelihood ratio (21.5) for CVC-RYF, although the 
      sensitivity was only 28%. DTTP was available for 52 patients. A DTTP >5 hours had 
      a sensitivity of 100% and a specificity of 71% for CVC-RYF. CONCLUSIONS: Since 
      the median TTP was 17 hours and the most performing DTTP >5 hours, these delays 
      are too long to take a decision in the same operational day. More rapid methods 
      for detecting infected catheters should be tested to avoid unnecessary CVC 
      withdrawal.
CI  - (c) 2019 Blackwell Verlag GmbH.
FAU - Gits-Muselli, Maud
AU  - Gits-Muselli M
AUID- ORCID: 0000-0002-0470-6866
AD  - Parasitology-Mycology Laboratory, Lariboisiere Saint-Louis Fernand Widal 
      Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
AD  - Paris-Diderot, Sorbonne Paris Cite University, Paris, France.
AD  - Molecular Mycology Unit, Institut Pasteur, Reference National Center of Invasive 
      Mycoses and Antifungals, CNRS UMR2000, Paris, France.
FAU - Villiers, Stephane
AU  - Villiers S
AD  - Anesthesiology Department, Lariboisiere Saint-Louis Fernand Widal Hospital, 
      Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Hamane, Samia
AU  - Hamane S
AD  - Parasitology-Mycology Laboratory, Lariboisiere Saint-Louis Fernand Widal 
      Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Bercot, Beatrice
AU  - Bercot B
AD  - Microbiology Department, Lariboisiere Saint-Louis Fernand Widal Hospital, 
      Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
AD  - Paris-Diderot, IAME UMR-1137, Sorbonne Paris Cite University, Paris, France.
FAU - Donay, Jean-Luc
AU  - Donay JL
AD  - Microbiology Department, Lariboisiere Saint-Louis Fernand Widal Hospital, 
      Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Denis, Blandine
AU  - Denis B
AUID- ORCID: 0000-0003-2101-2601
AD  - Tropical and Infectious Diseases Department, Lariboisiere Saint-Louis Fernand 
      Widal Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Guigue, Nicolas
AU  - Guigue N
AD  - Parasitology-Mycology Laboratory, Lariboisiere Saint-Louis Fernand Widal 
      Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Alanio, Alexandre
AU  - Alanio A
AD  - Parasitology-Mycology Laboratory, Lariboisiere Saint-Louis Fernand Widal 
      Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
AD  - Paris-Diderot, Sorbonne Paris Cite University, Paris, France.
AD  - Molecular Mycology Unit, Institut Pasteur, Reference National Center of Invasive 
      Mycoses and Antifungals, CNRS UMR2000, Paris, France.
FAU - Bretagne, Stephane
AU  - Bretagne S
AD  - Parasitology-Mycology Laboratory, Lariboisiere Saint-Louis Fernand Widal 
      Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
AD  - Paris-Diderot, Sorbonne Paris Cite University, Paris, France.
AD  - Molecular Mycology Unit, Institut Pasteur, Reference National Center of Invasive 
      Mycoses and Antifungals, CNRS UMR2000, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20191103
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Culture
MH  - Candida albicans/*isolation & purification
MH  - Candidemia/*blood
MH  - Catheter-Related Infections/*microbiology
MH  - Catheterization, Central Venous
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - blood cultures
OT  - candidaemia
OT  - central venous catheter
OT  - diagnosis
OT  - differential time to positivity
OT  - time to positivity
OT  - yeast fungaemia
EDAT- 2019/10/21 06:00
MHDA- 2020/05/15 06:00
CRDT- 2019/10/21 06:00
PHST- 2019/04/24 00:00 [received]
PHST- 2019/10/04 00:00 [revised]
PHST- 2019/10/10 00:00 [accepted]
PHST- 2019/10/21 06:00 [pubmed]
PHST- 2020/05/15 06:00 [medline]
PHST- 2019/10/21 06:00 [entrez]
AID - 10.1111/myc.13024 [doi]
PST - ppublish
SO  - Mycoses. 2020 Jan;63(1):95-103. doi: 10.1111/myc.13024. Epub 2019 Nov 3.