PMID- 31631339
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20231113
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 159
IP  - 2
DP  - 2020 Feb
TI  - Protection of Batf3-deficient mice from experimental cerebral malaria correlates 
      with impaired cytotoxic T-cell responses and immune regulation.
PG  - 193-204
LID - 10.1111/imm.13137 [doi]
AB  - Excessive inflammatory immune responses during infections with Plasmodium 
      parasites are responsible for severe complications such as cerebral malaria (CM) 
      that can be studied experimentally in mice. Dendritic cells (DCs) activate 
      cytotoxic CD8(+) T-cells and initiate immune responses against the parasites. 
      Batf3(-/-) mice lack a DC subset, which efficiently induces strong CD8 T-cell 
      responses by cross-presentation of exogenous antigens. Here we show that 
      Batf3(-/-) mice infected with Plasmodium berghei ANKA (PbA) were protected from 
      experimental CM (ECM), characterized by a stable blood-brain barrier (BBB) and 
      significantly less infiltrated peripheral immune cells in the brain. Importantly, 
      the absence of ECM in Batf3(-/-) mice correlated with attenuated responses of 
      cytotoxic T-cells, as their parasite-specific lytic activity as well as the 
      production of interferon gamma and granzyme B were significantly decreased. 
      Remarkably, spleens of ECM-protected Batf3(-/-) mice had elevated levels of 
      regulatory immune cells and interleukin 10. Thus, protection from ECM in 
      PbA-infected Batf3(-/-) mice was associated with the absence of strong CD8(+) 
      T-cell activity and induction of immunoregulatory mediators and cells.
CI  - (c) 2019 The Authors. Immunology Published by John Wiley & Sons Ltd.
FAU - Kuehlwein, Janina M
AU  - Kuehlwein JM
AUID- ORCID: 0000-0003-3648-2649
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
FAU - Borsche, Max
AU  - Borsche M
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
FAU - Korir, Patricia J
AU  - Korir PJ
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
FAU - Risch, Frederic
AU  - Risch F
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
FAU - Mueller, Ann-Kristin
AU  - Mueller AK
AD  - Parasitology Unit, Centre for Infectious Diseases, Heidelberg University 
      Hospital, Heidelberg, Germany.
AD  - DZIF German Center for Infection Research, Partner Site Heidelberg, Heidelberg, 
      Germany.
FAU - Hubner, Marc P
AU  - Hubner MP
AUID- ORCID: 0000-0001-8885-418X
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
FAU - Hildner, Kai
AU  - Hildner K
AD  - Medical Department 1, University Hospital Erlangen, Erlangen, Germany.
FAU - Hoerauf, Achim
AU  - Hoerauf A
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
AD  - DZIF German Center for Infection Research, Partner Site Bonn-Cologne, Bonn, 
      Germany.
FAU - Dunay, Ildiko Rita
AU  - Dunay IR
AD  - Institute of Inflammation and Neurodegeneration, University of Magdeburg, 
      Magdeburg, Germany.
FAU - Schumak, Beatrix
AU  - Schumak B
AUID- ORCID: 0000-0003-0749-3170
AD  - Institute of Medical Microbiology, Immunology and Parasitology, University 
      Hospital Bonn, Bonn, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191113
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (IFNG protein, mouse)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Repressor Proteins)
RN  - 0 (SNFT protein, mouse)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.21.- (Granzymes)
RN  - EC 3.4.21.- (Gzmb protein, mouse)
SB  - IM
MH  - Animals
MH  - Basic-Leucine Zipper Transcription Factors/*deficiency/genetics
MH  - Blood-Brain Barrier/immunology/parasitology
MH  - Brain/*immunology/metabolism/parasitology
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/metabolism/parasitology
MH  - Disease Models, Animal
MH  - Female
MH  - Granzymes/immunology/metabolism
MH  - Host-Parasite Interactions
MH  - Interferon-gamma/immunology/metabolism
MH  - Interleukin-10/immunology/metabolism
MH  - Malaria, Cerebral/immunology/metabolism/parasitology/*prevention & control
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Plasmodium berghei/immunology/*pathogenicity
MH  - Repressor Proteins/*deficiency/genetics
MH  - Spleen/immunology/metabolism/parasitology
MH  - T-Lymphocytes, Cytotoxic/*immunology/metabolism/parasitology
PMC - PMC6954726
OTO - NOTNLM
OT  - Plasmodium
OT  - T-cells
OT  - dendritic cells
OT  - experimental cerebral malaria
OT  - inflammation
EDAT- 2019/10/22 06:00
MHDA- 2020/02/06 06:00
PMCR- 2019/11/13
CRDT- 2019/10/22 06:00
PHST- 2019/05/12 00:00 [received]
PHST- 2019/09/30 00:00 [revised]
PHST- 2019/10/14 00:00 [accepted]
PHST- 2019/10/22 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/10/22 06:00 [entrez]
PHST- 2019/11/13 00:00 [pmc-release]
AID - IMM13137 [pii]
AID - 10.1111/imm.13137 [doi]
PST - ppublish
SO  - Immunology. 2020 Feb;159(2):193-204. doi: 10.1111/imm.13137. Epub 2019 Nov 13.