PMID- 31632109
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230519
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic 
      fatty liver disease in a diet-induced pre-diabetes rat model.
PG  - 1953-1962
LID - 10.2147/DMSO.S218626 [doi]
AB  - BACKGROUND: The increased prevalence of non-alcoholic fatty liver disease (NAFLD) 
      in type 2 diabetes mellitus (T2DM) patients is becoming a worldwide health 
      burden. Studies have indicated, however, that the onset of NAFLD occurs during 
      pre-diabetes, a condition that often precedes the onset of T2DM. Oleanolic acid 
      has been reported to improve glucose homeostasis in diet-induced pre-diabetes; 
      however, the effects of this triterpene on liver function have not been 
      evaluated. PURPOSE: This study was aimed at evaluating the therapeutic effects of 
      oleanolic acid (OA) on selected markers of NAFLD in a pre-diabetes rat model. 
      METHODS AND MATERIALS: Pre-diabetes was induced by exposing Sprague Dawley rats 
      to a high-fat high-carbohydrate diet for 20 weeks. The pre-diabetic rats were 
      then treated with OA (80 mg/kg) or metformin (500 mg/kg) in the presence and 
      absence of dietary interventions for a period of 12 weeks. The effects of OA were 
      evaluated on parameters including plasma triglycerides (TGs), very low-density 
      lipoprotein (VLDL) particles, bilirubin, AST, ALT, SREBP and antioxidant profile 
      while the livers were collected for histological analysis. RESULTS: The findings 
      of this study showed that the administration of OA to pre-diabetic rats 
      ameliorated body/liver weights ratio and significantly decreased plasma 
      triglycerides (TGs) and VLDL. Furthermore, OA also ameliorated hepatic oxidative 
      stress, lowered the SREBP expression and intrahepatic TGs. In addition, OA 
      administration decreased plasma concentrations of bilirubin and liver damage 
      enzyme biomarkers. CONCLUSION: The findings of the study suggest that OA 
      ameliorates the risk of developing pre-diabetes-related NAFLD through the 
      prevention of intrahepatic fat accumulation while also lowering hepatic 
      inflammation.
CI  - (c) 2019 Gamede et al.
FAU - Gamede, Mlindeli
AU  - Gamede M
AUID- ORCID: 0000-0001-5512-1545
AD  - School of Laboratory Medicine and Medical Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Durban, South Africa.
FAU - Mabuza, Lindokuhle
AU  - Mabuza L
AD  - School of Laboratory Medicine and Medical Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Durban, South Africa.
FAU - Ngubane, Phikelelani
AU  - Ngubane P
AUID- ORCID: 0000-0003-2150-1149
AD  - School of Laboratory Medicine and Medical Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Durban, South Africa.
FAU - Khathi, Andile
AU  - Khathi A
AD  - School of Laboratory Medicine and Medical Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Durban, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20191001
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6778448
OTO - NOTNLM
OT  - NAFLD and oleanolic acid
OT  - insulin resistance
OT  - pre-diabetes
COIS- The authors report no conflict of interest in this work.
EDAT- 2019/10/22 06:00
MHDA- 2019/10/22 06:01
PMCR- 2019/10/01
CRDT- 2019/10/22 06:00
PHST- 2019/06/07 00:00 [received]
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/10/22 06:00 [entrez]
PHST- 2019/10/22 06:00 [pubmed]
PHST- 2019/10/22 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - 218626 [pii]
AID - 10.2147/DMSO.S218626 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Oct 1;12:1953-1962. doi: 10.2147/DMSO.S218626. 
      eCollection 2019.