PMID- 31632546
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 11
IP  - 9
DP  - 2019
TI  - Effects of microbubble-enhanced ultrasound combined with prothrombin on microwave 
      ablation in rabbit VX2 liver tumor.
PG  - 5764-5775
AB  - OBJECTIVE: This study aimed to investigate effects of microbubble-enhanced 
      ultrasound (MEUS) combined with prothrombin on microwave ablation (MWA) on VX2 
      liver tumors in a rabbit model. METHODS: 80 rabbits with VX2 liver tumors were 
      randomly divided into Group A (sham + NS), Group B (sham + NS + P), Group C 
      (MEUS), and Group D (PMEUS). After treatment, targeted liver tumors were ablated 
      with MWA. On 0, 3, 7 and 14 d, volume of coagulated area was measured. Tissues in 
      ablated area, transition area and surrounding area were collected. RESULTS: On 0, 
      3, 7 and 14 d, coagulated volume in Group D was larger than remaining three 
      groups (P<0.05). On 7 d and 14 d, tumor volume in Group D was smaller than 
      remaining three groups (P<0.05). Fibrotic band in Group D was wider than in 
      remaining three groups (P<0.05). Cellular ultrastructure injury in ablated area 
      on 0 d and mitochondrial injury in transition area on 7 d were more severe in 
      Group D than in remaining three groups. On 0, 3, 7 and 14 d, proliferative 
      cellular nuclear antigen-positive index in transition area in Group C and Group D 
      was lower than Group A and Group B (P<0.05). On 0, 3 and 7 d, apoptosis index in 
      transition area in Group D was higher than remaining three groups (P<0.05). 
      CONCLUSIONS: MEUS combined with prothrombin on MWA can significantly expand 
      ablation volume, enhance the necrosis of ablated tissues, inhibit tumor 
      growth/metastasis and improve therapeutic effect of MWA on rabbit VX2 liver 
      tumors.
CI  - AJTR Copyright (c) 2019.
FAU - Shi, Ying
AU  - Shi Y
AD  - Department of Ultrasound, The Second Hospital of Shanxi Medical University 
      Taiyuan 030001, Shanxi, China.
AD  - Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University 
      Xi'an 710032, Shaanxi, China.
FAU - Yan, Ping
AU  - Yan P
AD  - Department of Biochemistry and Molecular Biology, Shanxi Medical University 
      Taiyuan 030001, Shanxi, China.
FAU - Luo, Zhenli
AU  - Luo Z
AD  - Department of Cardiology, The First Hospital of Yuncheng Yuncheng 044000, China.
FAU - Zhang, Junwang
AU  - Zhang J
AD  - Department of Gastroenterology, The Second Hospital of Shanxi Medical University 
      Taiyuan 030001, Shanxi, China.
FAU - Liu, Qiling
AU  - Liu Q
AD  - Department of Epidemic and Health Statistics, College of Public Health in Shaanxi 
      University of Chinese Medicine Xi'an 712046, Shaanxi, China.
FAU - Zhou, Xiaodong
AU  - Zhou X
AD  - Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University 
      Xi'an 710032, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20190915
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6789283
OTO - NOTNLM
OT  - Microbubble
OT  - VX2 liver tumor
OT  - microwave ablation
OT  - prothrombin
OT  - rabbit
COIS- None.
EDAT- 2019/10/22 06:00
MHDA- 2019/10/22 06:01
PMCR- 2019/09/15
CRDT- 2019/10/22 06:00
PHST- 2019/05/16 00:00 [received]
PHST- 2019/08/05 00:00 [accepted]
PHST- 2019/10/22 06:00 [entrez]
PHST- 2019/10/22 06:00 [pubmed]
PHST- 2019/10/22 06:01 [medline]
PHST- 2019/09/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2019 Sep 15;11(9):5764-5775. eCollection 2019.