PMID- 31633792
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210122
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 21
IP  - 2
DP  - 2020 Feb 1
TI  - Personalized Pain Goals and Responses in Advanced Cancer Patients.
PG  - e215-e221
LID - 10.1093/pm/pnz254 [doi]
AB  - OBJECTIVE: To assess the personalized pain intensity goal (PPIG), the achievement 
      of a personalized pain goal response (PPGR), and patients' global impression 
      (PGI) in advanced cancer patients after a comprehensive pain and symptom 
      management. DESIGN: Prospective, longitudinal. SETTING: Acute pain relief and 
      palliative/supportive care. SUBJECTS: 689 advanced cancer patients. METHODS: 
      Measurement of Edmonton Symptom Assessment Score (ESAS) and personalized pain 
      intensity goal (PPIG) at admission (T0). After a week (T7) personalized pain goal 
      response (PPGR) and patients' global impression (PGI) were evaluated. RESULTS: 
      The mean PPIG was 1.33 (SD 1.59). A mean decrease in pain intensity of - 2.09 was 
      required on PPIG to perceive a minimal clinically important difference (MCID). A 
      better improvement corresponded to a mean change of - 3.41 points, while a much 
      better improvement corresponded to a mean of - 4.59 points. Patients perceived a 
      MCID (little worse) with a mean increase in pain intensity of 0.25, and a worse 
      with a mean increase of 2.33 points. Higher pain intensity at T0 and lower pain 
      intensity at T7 were independently related to PGI. 207 (30.0%) patients achieved 
      PPGR. PPGR was associated with higher PPIG at T0 and T7, and inversely associated 
      to pain intensity at T0 and T7, and Karnofsky level. Patients with high pain 
      intensity at T0 achieved a favorable PGI, even when PPIG was not achieved by 
      PPGR. CONCLUSION: PPIG, PPGR and PGI seem to be relevant for evaluating the 
      effects of a comprehensive management of pain, assisting decision-making process 
      according to patients' expectations. Some factors may be implicated in 
      determining the individual target and the clinical response.
CI  - (c) 2019 American Academy of Pain Medicine. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Mercadante, Sebastiano
AU  - Mercadante S
AD  - Pain Relief & Supportive Care, La Maddalena Cancer Center, Palermo, Italy.
FAU - Adile, Claudio
AU  - Adile C
AD  - Pain Relief & Supportive Care, La Maddalena Cancer Center, Palermo, Italy.
FAU - Aielli, Federica
AU  - Aielli F
AD  - Department of Biotechnological and Applied Clinical Sciences, University of 
      L'Aquila, L'Aquila, Italy.
FAU - Gaetano, Lanzetta
AU  - Gaetano L
AD  - Medical Oncology Unit, IRCCS Neuromed, Pozzilli, Italy.
AD  - Medical Oncology Unit, Italian Neuro-Traumatology Institute, Grottaferrata, 
      Italy.
FAU - Mistakidou, Kyriaki
AU  - Mistakidou K
AD  - Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, 
      National & Kapodistrian University of Athens, School of Medicine, Athens, Greece.
FAU - Maltoni, Marco
AU  - Maltoni M
AD  - Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei 
      Tumori (IRST) IRCCS, Meldola, FC, Italy.
FAU - Soares, Luiz Guilherme
AU  - Soares LG
AD  - Post-Acute Care Services and Palliative Care Program, Hospital Placi, Niteroi, 
      Rio de Janeiro, Brazil.
FAU - DeSantis, Stefano
AU  - DeSantis S
AD  - Palliative Care and Oncologic Pain Service, S. Camillo-Forlanini Hospital, Rome, 
      Italy.
FAU - Ferrera, Patrizia
AU  - Ferrera P
AD  - Pain Relief & Supportive Care, La Maddalena Cancer Center, Palermo, Italy.
FAU - Rosati, Marta
AU  - Rosati M
AD  - Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei 
      Tumori (IRST) IRCCS, Meldola, FC, Italy.
FAU - Rossi, Romina
AU  - Rossi R
AD  - Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei 
      Tumori (IRST) IRCCS, Meldola, FC, Italy.
FAU - Casuccio, Alessandra
AU  - Casuccio A
AD  - Department of Sciences for Health Promotion and Mother Child Care, Universita di 
      Palermo, Palermo, Italy.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cancer Pain/*therapy
MH  - Female
MH  - *Goals
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Management/*methods
MH  - Pain Measurement/*methods
MH  - Precision Medicine/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Cancer Pain
OT  - Clinical Response
OT  - Pain Intensity
EDAT- 2019/10/22 06:00
MHDA- 2021/01/23 06:00
CRDT- 2019/10/22 06:00
PHST- 2019/10/22 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
PHST- 2019/10/22 06:00 [entrez]
AID - 5601659 [pii]
AID - 10.1093/pm/pnz254 [doi]
PST - ppublish
SO  - Pain Med. 2020 Feb 1;21(2):e215-e221. doi: 10.1093/pm/pnz254.