PMID- 31634752
OWN - NLM
STAT- MEDLINE
DCOM- 20210324
LR  - 20210324
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 120
DP  - 2020 Jan
TI  - Resistance training in patients with schizophrenia: Concept and proof of 
      principle trial.
PG  - 72-82
LID - S0022-3956(19)30628-4 [pii]
LID - 10.1016/j.jpsychires.2019.09.015 [doi]
AB  - Resistance training has been shown to contribute to the prevention and management 
      of cardiovascular diseases, which is why it can help reducing morbidity and 
      mortality in schizophrenia patients. Moreover, positive effects on different 
      schizophrenia symptom domains have been proposed. However, a specific resistance 
      training tailored to the needs of schizophrenia patients and its evaluation is 
      still lacking. The objective in this proof of principle trial was to evaluate the 
      feasibility and efficacy of a newly developed 12-week resistance program 
      according to current recommendations of the WHO and the American College of 
      Sports Medicine. We employed a single blind, parallel assignment clinical trial 
      design with participants randomized to attend either a resistance training 
      including three 50min units per week or a balance and tone program as control 
      condition. The primary outcome was the impact on health-related difficulties 
      assessed with the World Health Organization Disability Assessment Schedule 
      (WHO-DAS). Secondary outcome parameters included the level of functioning, 
      schizophrenia symptoms, selected cognitive parameters as well as risk factors for 
      cardiovascular diseases. In our proof of principle trial, we could not find 
      significant time or group effects of resistance training on the WHO-DAS. However, 
      we could observe significant positive effects on the level of functioning 
      assessed with the Global Assessment of Functioning Scale (GAF) over the course of 
      time, which were more pronounced in the intervention group. Our findings 
      indicated that patients with schizophrenia could safely participate in resistance 
      training with relevant improvements in their level of functioning. Well-powered 
      replication trials are needed to provide more efficacy data.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Maurus, I
AU  - Maurus I
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany. Electronic address: Isabel.Maurus@med.uni-muenchen.de.
FAU - Mantel, C
AU  - Mantel C
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Keller-Varady, K
AU  - Keller-Varady K
AD  - Hannover Medical School, Institute of Sports Medicine, Hannover, Germany.
FAU - Schmitt, A
AU  - Schmitt A
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Lembeck, M
AU  - Lembeck M
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Roh, A
AU  - Roh A
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Papazova, I
AU  - Papazova I
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Falkai, P
AU  - Falkai P
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Schneider-Axmann, T
AU  - Schneider-Axmann T
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Hasan, A
AU  - Hasan A
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Malchow, B
AU  - Malchow B
AD  - Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190927
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Adult
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Outcome and Process Assessment, Health Care
MH  - Proof of Concept Study
MH  - Resistance Training/*methods
MH  - Schizophrenia/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Exercise
OT  - GAF
OT  - Resistance
OT  - Schizophrenia
OT  - Strength training
EDAT- 2019/10/22 06:00
MHDA- 2021/03/25 06:00
CRDT- 2019/10/22 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/09/20 00:00 [revised]
PHST- 2019/09/25 00:00 [accepted]
PHST- 2019/10/22 06:00 [pubmed]
PHST- 2021/03/25 06:00 [medline]
PHST- 2019/10/22 06:00 [entrez]
AID - S0022-3956(19)30628-4 [pii]
AID - 10.1016/j.jpsychires.2019.09.015 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2020 Jan;120:72-82. doi: 10.1016/j.jpsychires.2019.09.015. Epub 
      2019 Sep 27.