PMID- 31635181 OWN - NLM STAT- MEDLINE DCOM- 20200413 LR - 20200413 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 55 IP - 10 DP - 2019 Oct 20 TI - Geographic Distribution, Phenotype and Epidemiological Tendency in Inflammatory Bowel Disease Patients in Romania. LID - 10.3390/medicina55100704 [doi] LID - 704 AB - Background and objective: The incidence of inflammatory bowel disease (IBD) over the past years in Romania has been on the rise, but epidemiologic data are lacking. The aim of this study was to define the characteristics of IBD, the trends and phenotype among IBD patients in Romania. Material and methods: We conducted a prospective study over a period of 12 years, from 2006 to 2017. All patients diagnosed with IBD on clinical, radiological, endoscopic and histological features were included. We divided the country into eight regions: west (W), north-east (NE), north-west (NW), south-east (SE), south-west (SW), south (S), central (C) and Bucharest-Ilfov (B), and data were analyzed accordingly. Results: A total of 2724 patients were included in this database, but only 2248 were included in the final analysis, with all data available. Of the 2248 patients, 935 were Crohn's disease (CD), 1263 were ulcerative colitis (UC) and 50 were IBD-undetermined. In UC phenotypes we observed more frequent left-sided colitis (50.5%, p < 0.0001), and in CD phenotype we observed more frequent colonic and ileo-colonic localization (37.8% and 37.6%, p < 0.0001). The region with the most IBD cases was NE (25.1%) and with the least IBD cases was SW (4.9%). UC was found more frequently in NE (32%), while CD was found more frequently in Bucharest (28.6%). Conclusions: In Romania, ulcerative colitis is more frequent than CD. UC is predominant in the northern part of Romania, while CD has become predominant in the southern part of the country. IBD occurs more in the male population, and in urban and industrialized areas. There are differences between the regions in Romania regarding IBD phenotypes, gender distributions, age distribution, treatment, smoking status and complications. FAU - Goldis, Adrian AU - Goldis A AD - Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. goldisadi@yahoo.com. FAU - Lupusoru, Raluca AU - Lupusoru R AD - Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. raluca_lupusoru@yahoo.ro. AD - Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. raluca_lupusoru@yahoo.ro. FAU - Gheorghe, Liana AU - Gheorghe L AD - Department of Gastroenterology and Hepatology, "Carol Davila" University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania. drlgheorghe@gmail.com. FAU - Gheorghe, Cristian AU - Gheorghe C AD - Department of Gastroenterology and Hepatology, "Carol Davila" University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania. drgheorghe@xnet.ro. FAU - Trifan, Anca AU - Trifan A AD - Gastroenterology and Hepatology Institute, "Grigore T. Popa" University of Medicine and Pharmacy, 700019 Iasi, Romania. ancatrifan@yahoo.com. FAU - Dobru, Daniela AU - Dobru D AD - Municipal Hospital, Gastroenterology, University of Medicine and Pharmacy, 540139 Targu-Mures, Romania. danidobru@gmail.com. FAU - Cijevschi, Cristina AU - Cijevschi C AD - Gastroenterology and Hepatology Institute, "Grigore T. Popa" University of Medicine and Pharmacy, 700019 Iasi, Romania. cristinacijevschi@yahoo.com. FAU - Tantau, Alina AU - Tantau A AD - "Iuliu Hatieganu" University of Medicine and Pharmacy, 3rd Medical Clinic, 400012 Cluj-Napoca, Romania. alina.i.tantau@gmail.com. FAU - Constantinescu, Gabriel AU - Constantinescu G AD - Department of Gastroenterology and Hepatology, "Carol Davila" University of Medicine and Pharmacy, Floreasca Emergency Hospital, 020021 Bucharest, Romania. gabrielconstantinescu63@gmail.com. FAU - Iacob, Razvan AU - Iacob R AD - Department of Gastroenterology and Hepatology, "Carol Davila" University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania. raziacob@gmail.com. FAU - Goldis, Ramona AU - Goldis R AD - Algomed Policlinic, 300041 Timisoara, Romania. amalia_goldis@yahoo.com. FAU - Diculescu, Mircea AU - Diculescu M AD - Department of Gastroenterology and Hepatology, "Carol Davila" University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania. mmdiculescu@yahoo.com. LA - eng PT - Journal Article DEP - 20191020 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Adult MH - Analysis of Variance MH - Female MH - *Geographic Mapping MH - Humans MH - Incidence MH - Inflammatory Bowel Diseases/epidemiology/*genetics MH - Male MH - Middle Aged MH - *Phenotype MH - Prospective Studies MH - Retrospective Studies MH - Romania/epidemiology MH - Spatial Analysis PMC - PMC6843626 OTO - NOTNLM OT - Crohn's disease OT - IBD treatment OT - epidemiology OT - inflammatory bowel disease OT - phenotypes OT - ulcerative colitis COIS- The authors declare no conflict of interest. EDAT- 2019/10/23 06:00 MHDA- 2020/04/14 06:00 PMCR- 2019/10/20 CRDT- 2019/10/23 06:00 PHST- 2019/09/20 00:00 [received] PHST- 2019/10/15 00:00 [revised] PHST- 2019/10/17 00:00 [accepted] PHST- 2019/10/23 06:00 [entrez] PHST- 2019/10/23 06:00 [pubmed] PHST- 2020/04/14 06:00 [medline] PHST- 2019/10/20 00:00 [pmc-release] AID - medicina55100704 [pii] AID - medicina-55-00704 [pii] AID - 10.3390/medicina55100704 [doi] PST - epublish SO - Medicina (Kaunas). 2019 Oct 20;55(10):704. doi: 10.3390/medicina55100704.