PMID- 31636572
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 10
DP  - 2019
TI  - Normal Values of QT Variability in 10-s Electrocardiograms for all Ages.
PG  - 1272
LID - 10.3389/fphys.2019.01272 [doi]
LID - 1272
AB  - Aims: QT variability is a promising electrocardiographic marker. It has been 
      studied as a screening tool for coronary artery disease and left ventricular 
      hypertrophy, and increased QT variability is a known risk factor for sudden 
      cardiac death. Considering that comprehensive normal values for QT variability 
      were lacking, we set out to establish these in standard 10-s electrocardiograms 
      (ECGs) covering both sexes and all ages. Methods: Ten-second, 12-lead ECGs were 
      provided by five Dutch population studies (Pediatric Normal ECG Study, Leiden 
      University Einthoven Science Project, Prevention of Renal and Vascular End-stage 
      Disease Study, Utrecht Health Project, Rotterdam Study). ECGs were recorded 
      digitally and processed by well-validated analysis software. We selected 
      cardiologically healthy participants, 46% being women. Ages ranged from 11 days 
      to 91 years. After quality control, 13,828 ECGs were available. We assessed three 
      markers: standard deviation of QT intervals (SDqt), short-term QT variability 
      (STVqt), and QT variability index (QTVI). Results: For SDqt and STVqt, the median 
      and the lower limit of normal remained stable with age. The upper limit of normal 
      declined until around age 45, and increased strongly in the elderly, notably so 
      in women. This implies that a subset of the population, small enough not to have 
      appreciable effect on the median, shows a high degree of QT variability with a 
      possible risk of arrhythmias or worse, especially in women. Otherwise, sex 
      differences were negligible in all three measurements. For QTVI, median, and 
      normal limits decreased until age 20, and steadily went up afterwards except for 
      the lower limit of normal, which flattens off after age 65. Conclusion: We report 
      the first set of normal values for QT variability based on 10-s ECGs, for all 
      ages and both sexes.
CI  - Copyright (c) 2019 van den Berg, Kors, van Herpen, Bots, Hillege, Swenne, Stricker 
      and Rijnbeek.
FAU - van den Berg, Marten E
AU  - van den Berg ME
AD  - Department of Medical Informatics, Erasmus MC - University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Kors, Jan A
AU  - Kors JA
AD  - Department of Medical Informatics, Erasmus MC - University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - van Herpen, Gerard
AU  - van Herpen G
AD  - Department of Medical Informatics, Erasmus MC - University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Bots, Michiel L
AU  - Bots ML
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht University, Utrecht, Netherlands.
FAU - Hillege, Hans
AU  - Hillege H
AD  - Department of Cardiology, University Medical Center Groningen, Groningen, 
      Netherlands.
FAU - Swenne, Cees A
AU  - Swenne CA
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.
FAU - Stricker, Bruno H
AU  - Stricker BH
AD  - Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, 
      Rotterdam, Netherlands.
AD  - Department of Internal Medicine, Erasmus MC - University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
AD  - Inspectorate of Health Care, Utrecht, Netherlands.
FAU - Rijnbeek, Peter R
AU  - Rijnbeek PR
AD  - Department of Medical Informatics, Erasmus MC - University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20191004
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6788348
OTO - NOTNLM
OT  - QT variability
OT  - children
OT  - elderly
OT  - electrocardiography
OT  - heart-rate variability
OT  - normal limits
EDAT- 2019/10/23 06:00
MHDA- 2019/10/23 06:01
PMCR- 2019/10/04
CRDT- 2019/10/23 06:00
PHST- 2019/06/06 00:00 [received]
PHST- 2019/09/19 00:00 [accepted]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2019/10/23 06:01 [medline]
PHST- 2019/10/04 00:00 [pmc-release]
AID - 10.3389/fphys.2019.01272 [doi]
PST - epublish
SO  - Front Physiol. 2019 Oct 4;10:1272. doi: 10.3389/fphys.2019.01272. eCollection 
      2019.