PMID- 31637230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 7
DP  - 2019
TI  - Surface Study of Fe(3)O(4) Nanoparticles Functionalized With Biocompatible 
      Adsorbed Molecules.
PG  - 642
LID - 10.3389/fchem.2019.00642 [doi]
LID - 642
AB  - Surfaces of iron oxide of ferrimagnetic magnetite (Fe(3)O(4)) nanoparticles 
      (MNPs) prepared by Massart's method and their functionalized form (f-MNPs) with 
      succinic acid, L-arginine, oxalic acid, citric acid, and glutamic acid were 
      studied by dynamic light scattering (DLS), Fourier transform infrared 
      spectroscopy (FTIR-S), UV-vis, thermogravimetric analysis (TGA)/differential 
      scanning calorimetry (DSC), X-ray photoelectron spectroscopy (XPS), and 
      reflection electron energy loss spectroscopy (REELS). The XPS analysis of 
      elements and their chemical states at the surface of MNPs and f-MNPs revealed 
      differences in chemical bonding of atoms, content of carbon-oxygen groups, iron 
      oxide forms, iron oxide magnetic properties, adsorbed molecules, surface 
      coverage, and overlayer thickness, whereas the Auger parameters (derived from XPS 
      and Auger spectra) and elastic and inelastic scattering probabilities of 
      electrons on atoms and valence band electrons (derived from REELS spectra) 
      indicated modification of surface charge redistribution, electronic, and optical 
      properties. These modified properties of f-MNPs influenced their biological 
      properties. The surfaces biocompatible for L929 cells showed various cytotoxicity 
      for HeLa cells (10.8-5.3% of cell death), the highest for MNPs functionalized 
      with oxalic acid. The samples exhibiting the largest efficiency possessed smaller 
      surface coverage and thickness of adsorbed molecules layers, the highest content 
      of oxygen and carbon-oxygen functionalizing groups, the highest ratio of lattice 
      O(2-) and OH(-) to C sp(2) hybridizations on MNP surface, the highest ratio of 
      adsorbed O(-) and OH(-) to C sp(2) hybridizations on adsorbed molecule layers, 
      the closest electronic and optical properties to Fe(3)O(4), and the lowest degree 
      of admolecule polymerization. This high cytotoxicity was attributed to 
      interaction of cells with a surface, where increased content of oxygen groups, 
      adsorbed O(-), and OH(-) may play the role of additional adsorption and catalytic 
      sites and a large content of adsorbed molecule layers of carboxylic groups 
      facilitating Fenton reaction kinetics leading to cell damage.
CI  - Copyright (c) 2019 Lesiak, Rangam, Jiricek, Gordeev, Toth, Kover, Mohai and 
      Borowicz.
FAU - Lesiak, Beata
AU  - Lesiak B
AD  - Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
FAU - Rangam, N
AU  - Rangam N
AD  - Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
FAU - Jiricek, P
AU  - Jiricek P
AD  - Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czechia.
FAU - Gordeev, I
AU  - Gordeev I
AD  - Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czechia.
FAU - Toth, J
AU  - Toth J
AD  - Institute for Nuclear Research, Hungarian Academy of Sciences, Debrecen, Hungary.
FAU - Kover, L
AU  - Kover L
AD  - Institute for Nuclear Research, Hungarian Academy of Sciences, Debrecen, Hungary.
FAU - Mohai, M
AU  - Mohai M
AD  - Research Centre for Natural Sciences, Institute of Materials and Environmental 
      Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.
FAU - Borowicz, P
AU  - Borowicz P
AD  - Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20191004
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC6787174
OTO - NOTNLM
OT  - DLS
OT  - FTIR-S
OT  - HeLa cells
OT  - REELS
OT  - TGA/DSC
OT  - XPS
OT  - biocompatible acid functionalization
OT  - ferrimagnetic magnetite (Fe3O4) magnetic nanoparticles
EDAT- 2019/10/23 06:00
MHDA- 2019/10/23 06:01
PMCR- 2019/01/01
CRDT- 2019/10/23 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2019/10/23 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fchem.2019.00642 [doi]
PST - epublish
SO  - Front Chem. 2019 Oct 4;7:642. doi: 10.3389/fchem.2019.00642. eCollection 2019.