PMID- 31637295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 4
IP  - 5
DP  - 2019 Oct
TI  - Prognostic Significance of Peripheral T-Cell Subsets in Laryngeal Squamous Cell 
      Carcinoma.
PG  - 513-519
LID - 10.1002/lio2.304 [doi]
AB  - OBJECTIVES: The role of the immune system in head and neck squamous cell 
      carcinoma is controversial. The aim of our study was to analyze full blood counts 
      and distribution of T cell subsets in patients affected by laryngeal squamous 
      cell cancer (LSCC) and their association with clinical variables and survival. 
      STUDY DESIGN: Retrospective study. METHODS: We analyzed the levels of platelets, 
      lymphocytes, and neutrophils, as well as the CD4(+), CD8(+), and CD3(+) T-cell 
      subpopulations by cytofluorometry in LSCC patients. A cohort of healthy patients 
      was used as control group. The disease-specific survival (DSS) was considered as 
      survival outcome. RESULTS: Sixty-five LSCC patients and 48 controls were 
      enrolled. In LSCC patients, neutrophils were higher than in the healthy group 
      (P < .0001). The neutrophil-to-lymphocyte ratio (NLR) and the 
      platelet-to-lymphocyte ratio (PLR) were both higher in LSCC patients (P < .0001). 
      In patients treated for recurrent disease, the CD8(+)/CD3(+) ratio was increased 
      (P = .02), while the CD4(+)/CD8(+) (P = .03) and CD4(+)/CD3(+) (P = .04) ratios 
      were lower. In patients with lymph node metastases, leukocytes (P = .03), CD3(+) 
      (P = .04), and CD4(+) (P = .0098) were all higher. Among Stages III-IV patients, 
      low lymphocyte and low leukocyte count were associated with worse DSS. 
      CONCLUSION: Our data demonstrate that NLR and PLR are significantly increased in 
      LSCC. Lower CD4(+)/CD8(+) and CD3(+)/CD8(+) ratios are related to recurrent 
      disease and a higher level of CD3(+) and CD4(+) is associated with nodal 
      metastasis. LEVEL OF EVIDENCE: 4.
CI  - (c) 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley 
      Periodicals, Inc. on behalf of The Triological Society.
FAU - Marchi, Filippo
AU  - Marchi F
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Missale, Francesco
AU  - Missale F
AUID- ORCID: 0000-0002-5357-5348
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Incandela, Fabiola
AU  - Incandela F
AD  - Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione 
      IRCCS, National Cancer Institute of Milan University of Milan Milan Italy.
FAU - Filauro, Marta
AU  - Filauro M
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Mazzola, Francesco
AU  - Mazzola F
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Mora, Francesco
AU  - Mora F
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Paderno, Alberto
AU  - Paderno A
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Brescia 
      Brescia Italy.
FAU - Parrinello, Giampiero
AU  - Parrinello G
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
FAU - Piazza, Cesare
AU  - Piazza C
AUID- ORCID: 0000-0002-2391-9357
AD  - Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione 
      IRCCS, National Cancer Institute of Milan University of Milan Milan Italy.
FAU - Peretti, Giorgio
AU  - Peretti G
AD  - IRCCS Ospedale Policlinico San Martino Genoa Italy.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery University of Genoa 
      Genoa Italy.
LA  - eng
PT  - Journal Article
DEP - 20190828
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC6793599
OTO - NOTNLM
OT  - Laryngeal cancer
OT  - hematologic tests
OT  - immune system
OT  - lymphocytes
OT  - outcome
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2019/10/23 06:00
MHDA- 2019/10/23 06:01
PMCR- 2019/08/28
CRDT- 2019/10/23 06:00
PHST- 2019/04/13 00:00 [received]
PHST- 2019/07/18 00:00 [revised]
PHST- 2019/08/10 00:00 [accepted]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2019/10/23 06:01 [medline]
PHST- 2019/08/28 00:00 [pmc-release]
AID - LIO2304 [pii]
AID - 10.1002/lio2.304 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2019 Aug 28;4(5):513-519. doi: 
      10.1002/lio2.304. eCollection 2019 Oct.