PMID- 31637308
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2397-0642 (Electronic)
IS  - 2397-0642 (Linking)
VI  - 4
DP  - 2019
TI  - A tool for estimating antiretroviral medication coverage for HIV-infected women 
      during pregnancy (PMTCT-ACT).
PG  - 29
LID - 10.1186/s41256-019-0121-3 [doi]
LID - 29
AB  - BACKGROUND: In the typical prevention of mother to child transmission (PMTCT) of 
      HIV cascade of care discussion or analysis, the period of analysis begins at the 
      first visit for antenatal care (ANC) for that pregnancy. This starting point is 
      problematic for two reasons: (1) a large number of HIV-infected women are already 
      on life-long antiretroviral therapy (ART) when presenting for ANC; and (2) women 
      present to ANC at different gestational ages. The PMTCT ART Coverage Tool 
      (PMTCT-ACT), which estimates the proportion of days covered (PDC) with ART, was 
      developed to address each of these problems. METHODS: PDC is a preferred method 
      to measure adherence to chronic medications, such as ART. For evaluating the 
      PMTCT cascade of care, as indicated by PDC with ART over various time periods, a 
      "starting point" based on a specific day before delivery must be defined that 
      applies to all women (treatment experienced or naive at the first ANC visit at 
      any gestational age). Using the example of 168 days prior to delivery (24 weeks), 
      PMTCT-ACT measures PDC with ART during that period. PMTCT-ACT is provided as a 
      STATA do-file. Using an example dataset for two women (ID1 is treatment 
      experienced; ID2 is treatment naive), the details of each major portion of the 
      tool (Parts 1-5) are presented. PMTCT-ACT along with the intermediate datasets 
      created during the analysis are provided as supplemental files. CONCLUSIONS: 
      Evaluating the PMTCT cascade of care requires a standard definition of the 
      follow-up period during pregnancy that applies to all HIV-infected pregnant women 
      and a standard measure of adherence. PMTCT-ACT is a new tool that fits this 
      purpose. PMTCT-ACT can also be easily adjusted to evaluate other ante- and 
      post-natal periods (e.g., final 4 weeks, final 8 weeks, complete pregnancy 
      period, initial 24 weeks postpartum, time periods consistent with infant HIV 
      testing guidelines).
CI  - (c) The Author(s) 2019.
FAU - Larson, Bruce A
AU  - Larson BA
AUID- ORCID: 0000-0002-9322-2387
AD  - 1Department of Global Health, Boston University School of Public Health, 801 
      Massachusetts Avenue, Boston, MA 02118 USA. ISNI: 0000 0004 1936 7558. GRID: 
      grid.189504.1
FAU - Halim, Nafisa
AU  - Halim N
AD  - 1Department of Global Health, Boston University School of Public Health, 801 
      Massachusetts Avenue, Boston, MA 02118 USA. ISNI: 0000 0004 1936 7558. GRID: 
      grid.189504.1
FAU - Tsikhutsu, Isaac
AU  - Tsikhutsu I
AD  - Kenya Medical Research Institute, U.S. Army Medical Research Directorate, Africa, 
      Kenya.
AD  - 3U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD USA. ISNI: 0000 0001 0036 4726. GRID: grid.420210.5
AD  - Henry Jackson Foundation MRI, Kericho, Kenya.
FAU - Bii, Margaret
AU  - Bii M
AD  - Kenya Medical Research Institute, U.S. Army Medical Research Directorate, Africa, 
      Kenya.
AD  - 3U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD USA. ISNI: 0000 0001 0036 4726. GRID: grid.420210.5
AD  - Henry Jackson Foundation MRI, Kericho, Kenya.
FAU - Coakley, Peter
AU  - Coakley P
AD  - 3U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD USA. ISNI: 0000 0001 0036 4726. GRID: grid.420210.5
FAU - Rockers, Peter C
AU  - Rockers PC
AD  - 1Department of Global Health, Boston University School of Public Health, 801 
      Massachusetts Avenue, Boston, MA 02118 USA. ISNI: 0000 0004 1936 7558. GRID: 
      grid.189504.1
LA  - eng
PT  - Journal Article
DEP - 20191015
PL  - England
TA  - Glob Health Res Policy
JT  - Global health research and policy
JID - 101705789
PMC - PMC6794749
OTO - NOTNLM
OT  - Cascade of care
OT  - Coverage
OT  - HIV
OT  - Pill count
OT  - Pregnancy
OT  - Prevention of mother-to-child transmission
OT  - Proportion of days covered
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2019/10/23 06:00
MHDA- 2019/10/23 06:01
PMCR- 2019/10/15
CRDT- 2019/10/23 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2019/10/23 06:01 [medline]
PHST- 2019/10/15 00:00 [pmc-release]
AID - 121 [pii]
AID - 10.1186/s41256-019-0121-3 [doi]
PST - epublish
SO  - Glob Health Res Policy. 2019 Oct 15;4:29. doi: 10.1186/s41256-019-0121-3. 
      eCollection 2019.