PMID- 31637610
OWN - NLM
STAT- MEDLINE
DCOM- 20201119
LR  - 20220307
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 39
IP  - 2
DP  - 2020 Feb
TI  - Stand-alone renal SLICC criterion with full house glomerular deposits: is it 
      enough for childhood lupus nephritis?
PG  - 401-405
LID - 10.1007/s10067-019-04789-7 [doi]
AB  - The objective of this study is to assess the usefulness of the stand-alone renal 
      SLICC criterion in patients with childhood systemic lupus erythematosus (cSLE) 
      and report their disease course, treatment response, and outcome. This study 
      included children who were followed regularly in our lupus clinic with proved 
      full house glomerular immune deposits nephritis and antinuclear (ANA), or 
      anti-double-stranded DNA (dsDNA). They were compared with patients who diagnosed 
      with cSLE with and without biopsy proven nephritis, based on Systemic Lupus 
      International Collaborating (SLICC). The comparative group selected by systematic 
      sampling from our cSLE database; the first patient was chosen randomly, and the 
      subsequent patients chosen at intervals of three. The two groups were compared in 
      respect to demographic data, clinical and laboratory findings, and disease course 
      including response to treatment and outcome using urine protein/creatinine ratio, 
      eGFR, and urine sediments. A total of 37 patients were assessed, six patients met 
      the stand-alone renal SLICC criterion, 18 patients had cSLE with biopsy proven 
      nephritis, and 13 cSLE patients without biopsy proven nephritis. Age of onset and 
      time to diagnosis were comparable. However, patients with stand-alone renal 
      criterion had significantly higher baseline serum creatinine, urine 
      protein/creatinine ratio, and lower ANA titer (p < 0.05). Furthermore, none of 
      the patients had other lupus manifestations. Four patients showed partial 
      response to treatment. Two patients had renal impairment and one patient 
      developed end-stage renal disease. Patients with full house glomerular immune 
      deposits nephritis and ANA, or anti-dsDNA reflect a different disease spectrum 
      with severe renal manifestations and worse outcome. Further large prospective 
      study is required to revisit the validity of the stand-alone renal SLICC 
      criterion in cSLE. KEY POINTS : * There is no definite diagnostic tool for SLE. 
      Furthermore, to date there are no specific classification criteria for cSLE. * It 
      seems that patients who met the stand-alone renal SLICC criterion might represent 
      a distinct disease spectrum with severe renal involvement.
FAU - Almutairi, Abdulaziz
AU  - Almutairi A
AD  - Pediatric Rheumatology, King Faisal Specialist Hospital and Research Center, PO 
      Box 3354, Riyadh, 11211, Saudi Arabia.
FAU - Aljammz, Hadeel
AU  - Aljammz H
AD  - Pediatric Rheumatology, King Faisal Specialist Hospital and Research Center, PO 
      Box 3354, Riyadh, 11211, Saudi Arabia.
FAU - Al-Hussain, Turki
AU  - Al-Hussain T
AD  - Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research 
      Center, Riyadh, Saudi Arabia.
FAU - Al-Mayouf, Sulaiman M
AU  - Al-Mayouf SM
AUID- ORCID: 0000-0003-0142-6698
AD  - Pediatric Rheumatology, King Faisal Specialist Hospital and Research Center, PO 
      Box 3354, Riyadh, 11211, Saudi Arabia. mayouf@kfshrc.edu.sa.
AD  - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. 
      mayouf@kfshrc.edu.sa.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20191021
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Antibodies, Antinuclear/*blood
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Kidney Glomerulus/*immunology
MH  - Lupus Nephritis/blood/*diagnosis/immunology/therapy
MH  - Male
OTO - NOTNLM
OT  - Childhood
OT  - Nephritis
OT  - Stand-alone renal criterion
OT  - Systemic lupus erythematosus
EDAT- 2019/10/23 06:00
MHDA- 2020/11/20 06:00
CRDT- 2019/10/23 06:00
PHST- 2019/07/25 00:00 [received]
PHST- 2019/09/21 00:00 [accepted]
PHST- 2019/09/04 00:00 [revised]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2019/10/23 06:00 [entrez]
AID - 10.1007/s10067-019-04789-7 [pii]
AID - 10.1007/s10067-019-04789-7 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2020 Feb;39(2):401-405. doi: 10.1007/s10067-019-04789-7. Epub 
      2019 Oct 21.