PMID- 31638436 OWN - NLM STAT- MEDLINE DCOM- 20210122 LR - 20210122 IS - 1557-8593 (Electronic) IS - 1520-9156 (Linking) VI - 22 IP - 2 DP - 2020 Feb TI - Clinical Profile of Elderly Patients (Over 90 Years) with Type 2 Diabetes Seen at a Diabetes Center in South India. PG - 79-84 LID - 10.1089/dia.2019.0219 [doi] AB - Background: The current life expectancy in India is <70 years. Type 2 diabetes mellitus (T2DM) is known to reduce life expectancy by 6-8 years. Hence elderly people with T2DM in India would be rare. We report on the clinical profile of Asian Indian patients with T2DM who lived beyond 90 years of age and compared them with T2DM patients aged 50 to 60 years. Methods: From the diabetes electronic medical records of >470,000 diabetes patients, we identified T2DM patients who had lived >/=90 years and compared them with those in the 50-60 years age group, matched for gender and duration of diabetes. Clinical data included age at last visit, age at diagnosis, duration of diabetes, family history, smoking and alcohol, details of medications, body mass index (BMI), and blood pressure. Biochemical data included fasting and postprandial plasma glucose, glycated hemoglobin, fasting and stimulated C-peptide levels, lipid profile, and renal function studies. Assessment of retinopathy, nephropathy, neuropathy, coronary artery disease (CAD), and peripheral vascular disease (PVD) was also done. Results: A total of 325 T2DM patients aged >/=90 years and 278 T2DM patients aged between 50 and 60 years were selected for the study. Patients aged >/=90 years had higher systolic blood pressure (P < 0.001) and lower BMI (P < 0.001) than those between 50 and 60 years. Prevalence of retinopathy (29.7% vs. 53.5%) and macroalbuminuria (3.7% vs. 16.0%) was lower in the >/=90 years T2DM patients than in the 50-60 years age group. However, prevalence of neuropathy (89.8% vs. 50.8%), PVD (13.5% vs. 2.0%), and CAD (60.3% vs. 32.0%) was higher among the >/=90 years patients. Eighty-five percent of the T2DM aged >/=90 years were on oral hypoglycemic agents (OHAs), (of whom 64.9% were on sulfonylurea), 12% were on insulin, and 3% on diet alone. Among the 50-60 years old, 87.8% were on OHAs and 12.2% on insulin. Conclusions: This is the first report on the clinical profile of Asian Indians with T2DM aged >/=90 years, and significant differences are seen in their clinical profile compared with younger T2DM patients. FAU - Viswanathan, Mohan AU - Viswanathan M AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India. FAU - Ranjit Mohan, Anjana AU - Ranjit Mohan A AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India. FAU - Ranjit, Unnikrishnan AU - Ranjit U AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India. FAU - Prasanna Kumar, Gupta AU - Prasanna Kumar G AD - Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India. FAU - Philips, Routary AU - Philips R AD - Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India. FAU - Saravanan, Jebarani AU - Saravanan J AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Ulagamathesan, Venkatesan AU - Ulagamathesan V AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Ganesan, Uma Sankari AU - Ganesan US AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Kumaradas, Gini Venisha AU - Kumaradas GV AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Rajendran, Ashok Kumar AU - Rajendran AK AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Thangarajan, Rahulashankiruthiyayan AU - Thangarajan R AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Rajendra, Pradeepa AU - Rajendra P AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. FAU - Coimbatore Subramanian, Shanthi Rani AU - Coimbatore Subramanian SR AD - Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Diabetes Technol Ther JT - Diabetes technology & therapeutics JID - 100889084 RN - 0 (Hypoglycemic Agents) SB - IM MH - *Age Factors MH - Aged, 80 and over MH - Albuminuria/epidemiology/etiology MH - Blood Pressure MH - Body Mass Index MH - Coronary Artery Disease/epidemiology/etiology MH - Diabetes Complications/*epidemiology/etiology MH - Diabetes Mellitus, Type 2/complications/*physiopathology/therapy MH - Diabetic Nephropathies/epidemiology/etiology MH - Diabetic Retinopathy/epidemiology/etiology MH - Diet, Diabetic/*statistics & numerical data MH - Female MH - Humans MH - Hypoglycemic Agents/*therapeutic use MH - India/epidemiology MH - Male MH - Middle Aged MH - Peripheral Vascular Diseases/epidemiology/etiology MH - Prevalence OTO - NOTNLM OT - Aged 90 years OT - Asian Indians OT - Elderly patients OT - Indian nonagenarians EDAT- 2019/10/23 06:00 MHDA- 2021/01/23 06:00 CRDT- 2019/10/23 06:00 PHST- 2019/10/23 06:00 [pubmed] PHST- 2021/01/23 06:00 [medline] PHST- 2019/10/23 06:00 [entrez] AID - 10.1089/dia.2019.0219 [doi] PST - ppublish SO - Diabetes Technol Ther. 2020 Feb;22(2):79-84. doi: 10.1089/dia.2019.0219.