PMID- 31639271
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 41
IP  - 2
DP  - 2020 Feb 1
TI  - Dynamic functioning of transient resting-state coactivation networks in the Human 
      Connectome Project.
PG  - 373-387
LID - 10.1002/hbm.24808 [doi]
AB  - Resting-state analyses evaluating large-scale brain networks have largely focused 
      on static correlations in brain activity over extended time periods, however 
      emerging approaches capture time-varying or dynamic patterns of transient 
      functional networks. In light of these new approaches, there is a need to 
      classify common transient network states (TNS) in terms of their spatial and 
      dynamic properties. To fill this gap, two independent resting state scans 
      collected in 462 healthy adults from the Human Connectome Project were evaluated 
      using coactivation pattern analysis to identify (eight) TNS that recurred across 
      participants and over time. These TNS spatially overlapped with prototypical 
      resting state networks, but also diverged in notable ways. In particular, 
      analyses revealed three TNS that shared cortical midline overlap with the default 
      mode network (DMN), but these "complex" DMN states also encompassed distinct 
      regions that fall beyond the prototypical DMN, suggesting that the DMN defined 
      using static methods may represent the average of distinct complex-DMN states. Of 
      note, dwell time was higher in "complex" DMN states, challenging the idea that 
      the prototypical DMN, as a single unit, is the dominant resting-state network as 
      typically defined by static resting state methods. In comparing the two resting 
      state scans, we also found high reliability in the spatial organization and 
      dynamic activities of network states involving DMN or sensorimotor regions. 
      Future work will determine whether these TNS defined by coactivation patterns are 
      in other samples, and are linked to fundamental cognitive properties.
CI  - (c) 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
FAU - Janes, Amy C
AU  - Janes AC
AUID- ORCID: 0000-0002-3749-5006
AD  - Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, 
      Massachusetts.
FAU - Peechatka, Alyssa L
AU  - Peechatka AL
AD  - Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, 
      Massachusetts.
FAU - Frederick, Blaise B
AU  - Frederick BB
AD  - Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, 
      Massachusetts.
FAU - Kaiser, Roselinde H
AU  - Kaiser RH
AD  - Department of Psychology and Neuroscience, University of Colorado Boulder, 
      Boulder, Colorado.
LA  - eng
GR  - P41 EB027061/EB/NIBIB NIH HHS/United States
GR  - R01 NS097512/NS/NINDS NIH HHS/United States
GR  - R01 MH117131/MH/NIMH NIH HHS/United States
GR  - U54 MH091657/MH/NIMH NIH HHS/United States
GR  - K02 DA042987/DA/NIDA NIH HHS/United States
GR  - MH117131/MH/NIMH NIH HHS/United States
GR  - F31 MH011713/MH/NIMH NIH HHS/United States
GR  - R01 AG029135/AG/NIA NIH HHS/United States
GR  - R01 AI029135/AI/NIAID NIH HHS/United States
GR  - R01 DA039135/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20191022
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/diagnostic imaging/*physiology
MH  - *Connectome
MH  - Default Mode Network/diagnostic imaging/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/*physiology
MH  - Young Adult
PMC - PMC7268046
OTO - NOTNLM
OT  - Human Connectome Project
OT  - coactivation pattern analysis
OT  - dynamics
OT  - resting state
OT  - transient network states
COIS- The authors have no other conflict of interest.
EDAT- 2019/10/23 06:00
MHDA- 2021/07/13 06:00
PMCR- 2019/10/22
CRDT- 2019/10/23 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/08/29 00:00 [revised]
PHST- 2019/09/16 00:00 [accepted]
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/22 00:00 [pmc-release]
AID - HBM24808 [pii]
AID - 10.1002/hbm.24808 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2020 Feb 1;41(2):373-387. doi: 10.1002/hbm.24808. Epub 2019 Oct 
      22.