PMID- 31639312
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20240328
IS  - 1558-9110 (Electronic)
IS  - 1058-0360 (Print)
IS  - 1058-0360 (Linking)
VI  - 29
IP  - 1S
DP  - 2020 Feb 21
TI  - Western Aphasia Battery-Revised Profiles in Primary Progressive Aphasia and 
      Primary Progressive Apraxia of Speech.
PG  - 498-510
LID - 10.1044/2019_AJSLP-CAC48-18-0217 [doi]
AB  - Purpose The primary aim was to examine the utility of the Western Aphasia 
      Battery-Revised (WAB-R; Kertesz, 2007) for classifying variants of primary 
      progressive aphasia (PPA). Traditional WAB-R metrics of Aphasia Quotient (AQ), 
      subtest scores, WAB-R classification, and several novel metrics were examined. A 
      secondary aim was to examine these same WAB-R metrics in individuals with primary 
      progressive apraxia of speech (PPAOS). Method A retrospective analysis of WAB-R 
      records from 169 participants enrolled in a study of neurodegenerative speech and 
      language disorders was conducted. PPA/PPAOS classification was determined by 
      consensus review of speech, language, and cognitive profiles. Scores on each of 
      the WAB-R subtests were obtained to derive AQ, WAB-R aphasia profile, and 3 
      ratios reflecting relative performance on subtests. Results Mean AQ was 
      significantly higher in the PPAOS group compared to all PPA variants except 
      primary fluent aphasia. AQ above the normal cutoff was observed for 20% of 
      participants with PPA. Significant main effects of group were noted for each of 
      the subtests. Follow-up comparisons most frequently discriminated PPAOS, primary 
      agrammatic aphasia (PAA), and logopenic progressive aphasia. Primary fluent 
      aphasia and semantic dementia (SD) subtest scores were less distinctive, with the 
      exception of Naming for SD, which was significantly lower than for PAA and PPAOS. 
      When the WAB-R AQ detected aphasia, a classification of anomic aphasia was most 
      frequently observed; this pattern held true for each of the PPA variants. The 
      mean Information Content:Naming ratio was highest for SD, and the mean 
      Comprehension:Fluency ratio was highest for PAA. Conclusions In the current 
      study, AQ underestimated the presence of PPA and WAB-R classification did not 
      distinguish among PPA classification determined by consensus. Performance on 
      individual subtests and relative performance across subtests demonstrated 
      inconsistent alignment with PPA classification. We conclude the WAB-R in 
      isolation is inadequate to detect or characterize PPA. We instead suggest 
      utilizing the WAB-R as 1 component of a comprehensive language and motor speech 
      assessment when PPA is suspected.
FAU - Clark, Heather M
AU  - Clark HM
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Utianski, Rene L
AU  - Utianski RL
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Duffy, Joseph R
AU  - Duffy JR
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Strand, Edythe A
AU  - Strand EA
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Botha, Hugo
AU  - Botha H
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Josephs, Keith A
AU  - Josephs KA
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Whitwell, Jennifer L
AU  - Whitwell JL
AD  - Division of Radiology Research, Mayo Clinic, Rochester, MN.
LA  - eng
GR  - R01 DC010367/DC/NIDCD NIH HHS/United States
GR  - R01 DC012519/DC/NIDCD NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20191022
PL  - United States
TA  - Am J Speech Lang Pathol
JT  - American journal of speech-language pathology
JID - 9114726
SB  - IM
MH  - Aged
MH  - Aphasia, Primary Progressive/classification/*diagnosis
MH  - Apraxias/classification/*diagnosis
MH  - Humans
MH  - Language Tests/*standards
MH  - Mental Status and Dementia Tests
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC7233113
EDAT- 2019/10/23 06:00
MHDA- 2021/01/20 06:00
PMCR- 2019/10/22
CRDT- 2019/10/23 06:00
PHST- 2019/10/23 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2019/10/23 06:00 [entrez]
PHST- 2019/10/22 00:00 [pmc-release]
AID - 23814764000300140072 [pii]
AID - 10.1044/2019_AJSLP-CAC48-18-0217 [doi]
PST - ppublish
SO  - Am J Speech Lang Pathol. 2020 Feb 21;29(1S):498-510. doi: 
      10.1044/2019_AJSLP-CAC48-18-0217. Epub 2019 Oct 22.