PMID- 31641727
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 23
IP  - 9
DP  - 2019
TI  - Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary 
      Analysis of CRELES.
PG  - 788-795
LID - 10.1007/s12603-019-1251-5 [doi]
AB  - OBJECTIVES: Intrinsic capacity (IC) is one of the latest views of positive aging. 
      In its current status lacks a biological substrate amenable to be intervened. The 
      aim of this study was to determine the association of allostatic load (AL) with 
      IC. DESIGN: We present a cross-sectional analysis of the Costa Rican Longevity 
      and Healthy Aging Study. SETTING: This report is from a representative sample of 
      Costa Rican older adults; one of the countries that integrate the Central America 
      region. PARTICIPANTS: 2,827, 60-year or older community-dwelling individuals. 
      METHODS: An IC index was gathered and validated, including different domains: 
      cognitive, psychological, sensory, vitality and locomotion. AL was integrated 
      with: blood pressure, abdominal obesity, body mass index, HDL-cholesterol, 
      glycosylated hemoglobin, DHEAS, cortisol, epinephrine and norepinephrine. AL was 
      grouped in three categories according to the number of abnormal biomarkers (0-1, 
      2-3 and >/=4). Chronic diseases, socioeconomic level, sex and age were the 
      adjusting variables. Ordinal logistic regression models were estimated in order 
      to test the strength of the association. RESULTS: From a total sample of 1,888 
      individuals, 51% (n=962) were women, 36.4% were in the 60-69 age category. The 
      mean score of the IC index was of 6.6 (+/-2.2). Odds ratio (OR) of the adjusted 
      models were significant for the group of those with 2-3 abnormal biomarkers of AL 
      (OR 0.67, p=0.007) and also for those with >/=4 (OR 0.56, p=0.002), when compared 
      to the reference group of AL (0-1 abnormal biomarkers). CONCLUSIONS AND 
      IMPLICATIONS: AL showed an incremental association with IC, even when adjusted 
      for factors such as socioeconomic status and chronic diseases. Targeting 
      therapeutically AL could potentially improve IC in older adults and therefore 
      decreasing the progression to disability or to overt dependency.
FAU - Gutierrez-Robledo, L M
AU  - Gutierrez-Robledo LM
AD  - Luis Miguel Gutierrez-Robledo, MD, PhD, Instituto Nacional de Geriatria, Blvd. 
      Adolfo Ruiz Cortines (Periferico Sur) 2767, Col. San Jeronimo Lidice, Del. La 
      Magdalena Contreras, ciudad de Mexico, C.P. 10200, Mexico, E-mail address: 
      lmgutierrez@inger.gob.mx.
FAU - Garcia-Chanes, R E
AU  - Garcia-Chanes RE
FAU - Perez-Zepeda, M U
AU  - Perez-Zepeda MU
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Allostasis/*physiology
MH  - Biomarkers/blood
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Cholesterol, HDL/blood
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Dehydroepiandrosterone Sulfate/blood
MH  - Epinephrine/blood
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Healthy Aging/*physiology
MH  - Hispanic or Latino
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal
MH  - Odds Ratio
OTO - NOTNLM
OT  - Intrinsic capacity
OT  - aging
OT  - allostasis
OT  - healthy aging
COIS- Authors declare no conflict of interest
EDAT- 2019/10/24 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/10/24 06:00
PHST- 2019/10/24 06:00 [entrez]
PHST- 2019/10/24 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
AID - S1279-7707(23)01150-8 [pii]
AID - 10.1007/s12603-019-1251-5 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2019;23(9):788-795. doi: 10.1007/s12603-019-1251-5.