PMID- 31642019 OWN - NLM STAT- MEDLINE DCOM- 20200131 LR - 20200131 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 26 IP - 33 DP - 2019 Nov TI - The mediated role of complement C3 in PM(2.5) exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China. PG - 34479-34486 LID - 10.1007/s11356-019-06487-y [doi] AB - Diabetes mellitus (DM) is a common chronic disease worldwide. Ambient air pollution has long been proven to be associated with type 2 diabetes mellitus (T2DM) progression, but the underlying mechanism is not clear yet. In addition, previous studies mainly focused on the prevention of healthy people against the incidence of T2DM. We designed a panel study including two follow-ups and enrolled 39 patients with T2DM living in Beijing. Linear mixed model was fitted to assess the association between two pairs of variables (ambient air pollution exposure and C3 levels, ambient air pollution exposures and T2DM index). Mediation analysis of C3 between ambient air pollution exposure and indicators of T2DM progression was conducted. We found that PM2.5 exposures is are negatively associated with serum complement C3. Given that C3 might act as a protector of pancreas beta cell, PM2.5 exposures could accelerate disease in T2DM populations. No mediation effects were found. This study reveals that exposures to PM2.5 can cause progression of diseases among T2DM populations. FAU - Tong, Yuanren AU - Tong Y AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Pei, Lu AU - Pei L AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Luo, Kai AU - Luo K AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Zhao, Meiduo AU - Zhao M AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Xu, Jing AU - Xu J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Li, Ang AU - Li A AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. FAU - Li, Runkui AU - Li R AD - College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. AD - State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China. FAU - Yang, Mingan AU - Yang M AD - Division of Biostatistics and Epidemiology, Graduate School of Public Health, San Diego State University, San Diego, CA, 92182, USA. FAU - Xu, Qun AU - Xu Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. xuqun@ibms.cams.cn. LA - eng GR - 15-230/China Medical Board/ GR - 200909016/Gong-Yi Program of Chinese Ministry of Environmental Protection/ GR - 2017-I2M-1-009/The Chinese Academy of Medical Science Innovation Fund for Medical Sciences/ GR - 41771435/National Natural Science Foundation of China/ GR - 201704910297/China Scholarship Council/ GR - Y88Q0300YD/Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences/ PT - Journal Article DEP - 20191022 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Air Pollutants) RN - 0 (C3 protein, human) RN - 0 (Complement C3) RN - 0 (Particulate Matter) SB - IM MH - Aged MH - Air Pollutants/analysis MH - Air Pollution/analysis/*statistics & numerical data MH - Beijing MH - China/epidemiology MH - Complement C3/*metabolism MH - Diabetes Mellitus, Type 2/*epidemiology MH - Environmental Exposure/analysis/*statistics & numerical data MH - Female MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Particulate Matter/*analysis OTO - NOTNLM OT - C3 OT - Diabetes mellitus OT - Mediation effects OT - PM2.5 OT - T2DM population EDAT- 2019/10/24 06:00 MHDA- 2020/02/01 06:00 CRDT- 2019/10/24 06:00 PHST- 2019/03/26 00:00 [received] PHST- 2019/09/09 00:00 [accepted] PHST- 2019/10/24 06:00 [pubmed] PHST- 2020/02/01 06:00 [medline] PHST- 2019/10/24 06:00 [entrez] AID - 10.1007/s11356-019-06487-y [pii] AID - 10.1007/s11356-019-06487-y [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2019 Nov;26(33):34479-34486. doi: 10.1007/s11356-019-06487-y. Epub 2019 Oct 22.